DNA Origami is the act of folding strands of DNA into tiny nano-scale structures that will one day be used in cancer research. Sometimes, we want to measure the length of the structures, but this is very difficult given their small size. One way to measure their length is to attach fluorescent glowing particles to each end of the structure, then view them under a microscope that shoots a laser at the DNA Origami. Depending on the length of the structure, the fluorescent particles will glow a different color, helping us identify how short or long the structure is. In our exercise the laser light will not change colors, but we can use mirrors to reflect the light of a laser to help us estimate the length of an object without measuring with a ruler or other traditional measuring method.
Students will properly arrange mirrors at the ends of a DNA origami Structure and create a laser launch and catching device to measure the length of the structure from across the room.
This Guide provides the instructor information on how to run the design challenge with alternatives for materials and test setups as well as information to help make the design challenge a good educational experience.
The video conveys the societal impact of the student’s research that is the basis for the design challenge and will set the problem-solving context for students. The video also leads students through the design process. It indicates materials available, states what the criteria are for success and any constraints.