DNA Origami

There is an abundance of molecules and cells in the body that exert force upon one another. Force between molecules is important because further understanding of the behavior of molecules in the body can lead to a further understanding of certain diseases. Once the molecular mechanisms are fully understood, then better treatments and drugs can be developed. However, measuring these forces are not an easy task. Currently, large microscopes are used to measure force but a smaller method of measurement would lower the cost and improve the ease of measurement. In the Nanoengineering & Biodesign Lab we design structures made out of DNA. DNA is extremely small and allows for the creation for small measurements tools. Specifically, a structure called the RLS (Receptor-Ligand Slider) is used to measure force. The structure measures force with a spring like component, single strand DNA linker.

Using a Slinky as a single DNA and a ping pong ball as a molecule, students will create a structure that is strong enough to hold a molecule that will attach to another molecule.  The structure will need to be as small and strong as possible.

 A blue slinky with a white cardboard on its top and middle

DNA Origami TEK8 Student Guide

The student handout will be given to all students working on the design
challenge. It gives a brief recap of the story, it helps the students identify what they are attempting to achieve, and it recaps the design process.

DNA Origami TEK8 Instructor’s Guide

This Instructor’s Guide provides the instructor additional information on how to run the design challenge with alternatives for materials and test setups as well as information to help make the design challenge a good educational experience.

Telling the Story Video

The Telling the Story Video conveys the societal impact of the student’s research that is the basis for the design challenge and will set the problem-solving context for students.

Design Challenge Video

The Design Challenge Video leads students through the design process. It indicates materials available, states what the criteria are for success and any constraints. It also gives a second ‘level’ of the design challenge that allows ‘early completers’ to move on to a slightly more difficult challenge.

PowerPoint Presentation

The presentation can be used in conjunction or in place of the Design Challenge Video.