Study: Alcohol might cause brain changes

In a recent national survey of over 30,000 college students, almost 2 out of 3 college students reported using ANY alcohol in the last 30 days (1).

In 2011, almost 70 million Americans reported binge drinking in the last month ( binge drinking defined by the survey as 5 or more drinks on one occasion) (2).

In some people, alcohol can impact emotional health by altering important brain chemicals involved in regulating mood, anxiety.

A previous post looked at the impact of alcohol on grades (3), and alcohol’s impact on sexual assault (4). A recent study looked at the impact of alcohol on brain health (5).

Who was studied? (5)

  • 550 men and women with mean age 43.0, were followed weekly over a 30 year time period.
  • None of the participants had alcohol dependence at the beginning of the study.
  • What was measured? (5)
  • Alcohol intake and cognitive performance were measured on a weekly basis.
  • Multimodal magnetic resonance imaging (MRI) was performed at the end of the study (2012-15).Even after adjusting for various factors:

What were the results? (5)

  • In this study, higher alcohol consumption over 30 years was associated with higher odds of hippocampal atrophy.
  • Even those drinking moderately (14-21 units/week) had 3x higher odds of right sided hippocampal atrophy.
  • In this study, there was NO protective effect of light drinking (1-<7 units/week) over abstinence.
  • Higher alcohol use was also associated with differences in corpus callosum microstructure and faster decline in lexical fluency (selecting and retrieving information based on spelling).

What does this mean? (5)

  • Hippocampus changes are implicated in Alzheimer’s disease (6) and depression (7)
  • Alcohol consumption might also impact lexical fluency (selecting and retrieving information based on spelling) (5)
  • Caution is advised even with long term non dependent use of alcohol.

What are some caveats?

  • This is a single, small study of middle age adults in a small region, which limits generalization world wide.
  • Participants could not be randomized.
  • Further study is needed.

Where can I learn more about alcohol?

How much is too much, strategies for cutting down, quitting can be found here:

From what I have seen in research, the amount of alcohol that is considered safe continues to be lowered as we learn more about the impact of alcohol.

Are you regularly drinking alcohol?  How is it impacting your emotional and physical health?

By R. Ryan S Patel DO, FAPA OSU-CCS Psychiatrist

Disclaimer: This article is intended to be informative only. It is advised that you check with your own physician/mental health provider before implementing any changes. With this article, the author is not rendering medical advice, nor diagnosing, prescribing, or treating any condition, or injury; and therefore claims no responsibility to any person or entity for any liability, loss, or injury caused directly or indirectly as a result of the use, application, or interpretation of the material presented.

References

  1. American College Health Association. American College Health Association-National College Health Assessment II: Reference Group Executive Summary Fall 2016. Hanover, MD: American College Health Association; 2017.
  2. Center for Behavioral Health Statistics and Quality. Behavioral health trends in the United States: Results from the 2014 National Survey on Drug Use and Health (HHS Publication No. SMA 15-4927, NSDUH Series H-50); 2015.
  3. https://u.osu.edu/emotionalfitness/2014/09/12/does-alcohol-use-impact-your-grades/
  4. https://u.osu.edu/emotionalfitness/2015/10/21/study-alcohol-impacts-sexual-assault/
  5. Topiwala Anya, Allan Charlotte L, Valkanova Vyara, Zsoldos Enikő, Filippini Nicola, Sexton Claire et al. Moderate alcohol consumption as risk factor for adverse brain outcomes and cognitive decline: longitudinal cohort study BMJ 2017; 357 :j2353.
  6. McKhann GM, Knopman DS, Chertkow H, et al. The diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement2011;357:263-9.
  7. Masi, G. & Brovedani, P. CNS Drugs (2011) 25: 913. doi:10.2165/11595900-000000000-00000.  The Hippocampus, Neurotrophic Factors and Depression.

 

The lasting negative impact of bullying

By R. Ryan S Patel DO, FAPA, OSU-CCS Psychiatrist
Many students might be aware of emotional harm that can occur as a result of bullying. People may not know that being bullied as a child or a young person might lead to emotional problems that occur when you are an adult.
This was highlighted in a recent study.

What was studied?

Exposure to bullying and childhood maltreatment was assessed among 5466 children aged 8 to 16 years old.
Then, at 18 years of age, symptoms of anxiety, depression, self-harm, and suicidality were measured.
What did the study show?

This studied showed that adults who were bullied during childhood had an increased risk of anxiety, depression, and self-reported harm in the past year compared to the other groups.
What do the results mean?

While we know from studies that people who are victims of maltreatment during childhood are at an increased risk of various mental health problems during adulthood, this study suggests that people who are victims of bullying during childhood also has serious mental health consequences as the victims become adults.
It is hoped that future research will shed further light on this topic.

Have you experienced bullying in the past? Are you experiencing emotional problems now? Have you considered professional help?
Helpful resources
Counseling and medications can be helpful for a variety of mental health concerns.
ccs.osu.edu (counseling on campus)

stopbullying.gov

National Suicide Prevention Lifeline at 1-800-273-8255 to speak to trained counselor.
Disclaimer: This article is intended to be informative only. It is advised that you check with your own physician/mental health provider before implementing any changes. With this article, the author is not rendering medical advice, nor diagnosing, prescribing, or treating any condition, or injury; and therefore claims no responsibility to any person or entity for any liability, loss, or injury caused directly or indirectly as a result of the use, application, or interpretation of the material presented.

References
Adult mental health consequences of peer bullying and maltreatment in childhood: two cohorts in two countries. Suzet Tanya Lereya, William E Copeland, E Jane Costello, Dieter Wolke. www.thelancet.com/psychiatry Published online April 28, 2015 http://dx.doi.org/10.1016/S2215-0366(15)00165-0

Study: Smoking might increase your alcohol intake

By R. Ryan S Patel DO, FAPA, OSU-CCS Psychiatrist    alcohol and smokes (3)

Over 26 studies show (4) that smoking contributes to anxiety and depression and that you can feel good and increase happiness by quitting tobacco.
Students might also know about smoking cigarettes raising your risk of cancer, stroke, heart disease, breathing problems (1) and that quitting smoking can reduce these risks (2-3).
A recent study suggests smoking might increase your alcohol consumption (5-6).

What was the study?
In this animal study (5-6), rats were trained to press a bar to obtain alcohol and were exposed to nicotine or saline in different experimental designs.

What did the study show?
This study showed that, in alcohol-dependent animals, nicotine increased:
• The speed at which alcohol was ingested,
• The amount of work that animals would do to obtain alcohol (i.e., the number of times they would press a bar to get one dose), and
• The amount of drinking despite adverse consequences

What do the results suggest?
Quitting smoking might help you drink less or quit alcohol completely. Further study is needed.

How can I quit smoking?
http://swc.osu.edu/alcohol-tobacco-other-drugs/quit-tobacco/
http://tobaccofree.osu.edu/resources/
http://smokefree.gov/
http://www.cancer.org/healthy/stayawayfromtobacco/guidetoquittingsmoking/index
http://www.cancer.org/cancer/cancercauses/tobaccocancer/smokelesstobaccoandhowtoquit/index

Where can I learn more about alcohol?
How much is too much, Strategies for cutting down, quitting can be found here:
http://www.ccs.osu.edu/self-help/alcohol/
http://rethinkingdrinking.niaaa.nih.gov/default.asp

Take the OSU Free Anonymous Mental health Screen

Is smoking impacting your alcohol intake? Could you stand to feel better? Perform better academically? What other consequences are you experiencing from smoking or alcohol or both?

Disclaimer: This article is intended to be informative only. It is advised that you check with your own physician/mental health provider before implementing any changes. With this article, the author is not rendering medical advice, nor diagnosing, prescribing, or treating any condition, or injury; and therefore claims no responsibility to any person or entity for any liability, loss, or injury caused directly or indirectly as a result of the use, application, or interpretation of the material presented.

References
1. US Department of Health and Human Services. The health consequences of smoking: a
report of the Surgeon General. US Department of Health and Human Services, 2004.
2. US Department of Health and Human Services. The health benefits of smoking cessation.
US Department of Health and Human Services, 1990.
3. Pirie K, Peto R, Reeves G, Green J, Beral V. The 21st century hazards of smoking and
benefits of stopping: a prospective study of one million women in the UK. Lancet
2013;381:133-41.
4. Taylor G, et al. Change in mental health after smoking cessation: systematic review and meta-analysis. OPEN ACCESS. BMJ 2014;348:g1151 doi: 10.1136/bmj.g1151 (Published 13 February 2014).

5. Leão RM et al. Chronic nicotine activates stress/reward-related brain regions and facilitates the transition to compulsive alcohol drinking. J Neurosci 2015 Apr 15; 35:6241. (http://dx.doi.org/10.1523/JNEUROSCI.3302-14.2015);
6. May 4, 2015. Want to Stop Drinking? Don’t Smoke. Steven Dubovsky MD reviewing Leão RM et al. J Neurosci 2015 Apr 15. http://www.jwatch.org/na37661/2015/05/04/want-stop-drinking-dont-smoke?query=etoc_jwpsych#sthash.94sXS2T4.dpuf