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Scrub typhus and Orientia:
geography and genotype of a vector-borne disease
  • Home
    • Site updates
  • Scrub typhus – a neglected disease
    • Early scientific tsutsugamushi reports
    • Significant recent news and findings
  • Geography
    • EXPANDED GEOGRAPHIC DISTRIBUTION OF SCRUB TYPHUS
  • The agents of scrub typhus
  • Diagnostic Methods
    • SEROLOGICAL DIAGNOSTIC TECHNIQUES
    • MOLECULAR DIAGNOSTIC TECHNIQUES
  • Antibiotics: Treatment, Sensitivity and Resistance
  • The molecular genetics of scrub typhus
    • GROUP 1) SURFACE ANTIGEN GENES
      • 56 kDa Type Specific Antigen (TSA)
        • DNA sequences of the 56kDa TSA gene
      • 47-kDa membrane protease (htrA) gene
      • GroEL and GroES genes
      • 22-kDa CELL SURFACE ANTIGEN
    • GROUP 2) RIBOSOMAL RNA GENES
      • Ribosomal small subunit (16S) rRNA gene
      • Ribosomal large subunit (23S) rRNA gene
    • GROUP 3) Multi-locus Sequence Typing in Orientia
      • MLST Panel 1
      • MLST Panel 2
      • MLST PANEL 3
    • GROUP 4) GENES WITH POTENTIAL TO CONFER ANTIBIOTIC RESISTANCE
      • gyrA : DNA gyrase
      • Bcr/CflA drug resistance efflux transporter
      • The ABC-type multidrug transport system
      • RND family efflux transporters
      • Penicillin-binding proteins
      • Beta-lactamases
      • ampG1 – permease of the major facilitator superfamily
      • Microcin C resistance proteins
      • Additional Genes
      • Rickettsia genes missing in Orientia
      • Antibiotic Resistance Genes
    • FUTURE QUESTIONS ABOUT THE GENETIC VARIATION IN O. TSUTSUGAMUSHI
  • Phylogenetic relationships between isolates of scrub typhus
  • Genome sequences of scrub typhus isolates
  • Vectors of Scrub typhus
  • History of isolates of scrub typhus
    • The Gilliam strain
    • The Karp strain
    • The Kato strain
    • The Kuroki isolate
    • The Kawasaki isolate
    • The Shimokoshi isolate
    • The TA763 strain
    • The Boryong strain
    • The Kostival strain
    • Calcutta strain
  • Acknowledgments
  • American Society for Rickettsiology and other websites

GROUP 1) SURFACE ANTIGEN GENES

Surface antibody genes

22-kDa antigen: Details of the gene for the sca22

47-kDa antigen: Details of the gene for the sca47

56-kDa antigen:  Details of 56-kDa TSA gene

groEs / groEl: Details of the genes for sca57

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