Month: May 2020

Pesticide Toxicity : Chlorothalonil

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Introduction

  • Chlorothalonil is an organic compound used as a broad spectrum , non-systemic fungicide also used as pesticides , wood protect ,mold controller, acaricids.
  • Mostly used to control fungi that affects agro crops.
  • Products containing Chlorothalonil are sold under the names Echo , Bravo, Daconil.
  • Its one of the top 3  fungicide in the USA
  • First registered for use in 1997.
  • Read more

Properties

Molecular Formula C8Cl4N2
Molecular Mass 265.90 g·mol−1
Appearance white crystalline solid
Desnsity 1.8 g cm−3, solid
IUPAC Name 2,4,5,6-Tetrachlorobenzene-1,3-dicarbonitrile
Synonyms 2,4,5,6-Tetrachloroisophthalonitrile
Bravo
Daconil
Tetrachloroisophthalonitrile
Celeste
Bronco
Agronil
Aminil

 

How does Chlorothalonil work 

The video explains the mode of action of chlorothalonil.

Chlorothalonil deactivates glutathione actions.

 

Toxicology Effects

Acute Toxicity

  • Eye irritant
  • Skin irritant
  • Loss of muscle coordination
  • Rapid breathing
  • Bleeding nose
  • Hyperactivity

Chronic Toxicity

Is Chlorothalonil safe !

  • Always follow label instructions.
  • Wear personal protective equipments
  • Avoid risk of inhalation, ingestion, and coming in contact with the skin

 

 

Always Follow Label Instructions

Metabolism of Chlorothalonil following Oral administration to Rats

Clinical cases

  • Only few cases have been reported of adverse effects in humans.
  • Contact dermatitis is the most frequent diagnosis.

References:

1.Andre, J. C., et al. (1991a). “Comparison of the Effects of Dose Level and Vehicle on the Dermal Absorption of 14C-Chlorothalonil by Male Rats

2. “Chlorothalonil”. Pubchem

3. Gupta P.K.
Toxicity of Fungicides
Veterinary Toxicology: Basic and Clinical Principles: Third Edition, 2018

4.  PESTICIDE USE IN U.S. CROP PRODUCTION: 1997 Archived 10 December 2006 at the Wayback Machine National Center for Food and Agricultural Policy, 1997