The research conducted at the MINDSET lab aims to understand the impact of traumatic brain injury (TBI) and psychological stress on the brain and overall health outcomes. To achieve this, we employ cognitive neuroscience techniques, such as MRI, to investigate the neural underpinnings of cognitive processes like memory, attention, social, and emotional processes. Additionally, we explore how genetic and epigenetic factors moderate outcomes following injury and throughout the aging process. Our research focuses on the enduring effects of brain injury, including possible connections to neurodegenerative diseases like Alzheimer’s disease, as well as the interactions with mental health disorders.
Military Injuries
Our research investigates the impact of military concussion and posttraumatic stress on brain function and structure, as well as cognitive and health outcomes. Service members who have served in recent wars have been exposed to blast-related traumatic brain injuries and chronic stress, which can result in brain changes for some individuals. Our studies have revealed that military personnel who experienced a loss-of-consciousness with their mild TBI are at a higher risk for axonal injury years after the incident compared to those who did not lose consciousness. Moreover, we have identified correlations between brain injury and post-concussion symptoms, including headaches, by examining these individuals.
Sports Injuries
In addition, we investigate the impact of sports concussion on brain function and structure. Recent research has revealed that head impacts sustained during certain sports are linked to neurodegenerative diseases, such as chronic traumatic encephalopathy. Nonetheless, not all athletes who experience concussions will suffer from negative long-term consequences. Therefore, our laboratory is exploring individual differences that could predict who might experience negative outcomes in the future.
Posttraumatic Stress Disorder
After experiencing life-threatening events like assaults, combat, and motor-vehicle accidents, certain individuals may develop posttraumatic stress disorder. This condition is distinguished by unwanted and intrusive memories of the traumatic event, negative mood, avoidance, and heightened arousal response. Our research delves into the impact of chronic stress on the brain and cognition, as well as the enduring effects of prolonged stress reactions. Our ultimate objective is to comprehend how treatment can normalize brain changes to facilitate healing.