Publications

Slit2/Robo1 signaling inhibits small-cell lung cancer by targeting β-catenin signaling in tumor cells and macrophages.

Ahirwar DK, Peng B, Charan M, Misri S, Mishra S, Kaul K, Sassi S, Gadepalli VS, Siddiqui J, Miles WO, Ganju RK. Molecular Oncology. 2022 Jul 15. doi: 10.1002/1878-0261.13289. PMID: 35838343

 

PUMILIO competes with AUF1 to control DICER1 RNA levels and miRNA processing.

Rajasekaran S, Khan E, Ching SR, Khan M, Siddiqui JK, Gradia DF, Lin C, Bouley SJ, Mercadante DL, Manning AL, Gerber AP, Walker JA, Miles WO. Nucleic Acids Research. 2022 Jul 8;50(12):7048-7066. doi: 10.1093/nar/gkac499. PMID: 35736218.

 

Drivers of genomic loss of heterozygosity in leiomyosarcoma are distinct from carcinomas.

Seligson ND, Tang J, Jin DX, Bennett MP, Elvin JA, Graim K, Hays JL, Millis SZ, Miles WO, Chen JL. NPJ Precision Oncology. 2022 Apr 25;6(1):29. doi: 10.1038/s41698-022-00271-x.PMID: 35468996

 

Mass COVID-19 patient screening using UvsX and UvsY mediated DNA recombination and high throughput parallel sequencing.

Palmieri D, Javorina A, Siddiqui J, Gardner A, Fries A, Chapleau RR, Starr C, Fishel R, Miles WO. Scientific Reports. 2022 Mar 8;12(1):4082. doi: 10.1038/s41598-022-08034-1.PMID: 35260723

 

cPLA2 blockade attenuates S100A7-mediated breast tumorigenicity by inhibiting the immunosuppressive tumor microenvironment.

Mishra S, Charan M, Shukla RK, Agarwal P, Misri S, Verma AK, Ahirwar DK, Siddiqui J, Kaul K, Sahu N, Vyas K, Garg AA, Khan A, Miles WO, Song JW, Bhutani N, Ganju RK. Journal of Experimental Clinical Cancer Research. 2022 Feb 8;41(1):54. doi: 10.1186/s13046-021-02221-0. PMID: 35135586

 

Clinical Utility of CDK4/6 Inhibitors in Sarcoma: Successes and Future Challenges.

Hsu JY, Seligson ND, Hays JL, Miles WO, Chen JL. JCO Precision Oncology. 2022 Feb;6:e2100211. doi: 10.1200/PO.21.00211.PMID: 35108033 Free PMC article.

 

Reduced RBPMS Levels Promote Cell Proliferation and Decrease Cisplatin Sensitivity in Ovarian Cancer Cells.

Rabelo-Fernández RJ, Santiago-Sánchez GS, Sharma RK, Roche-Lima A, Carrion KC, Rivera RAN, Quiñones-Díaz BI, Rajasekaran S, Siddiqui J, Miles W, Rivera YS, Valiyeva F, Vivas-Mejia PE. International Journal of Molecular Science. 2022 Jan 4;23(1):535. doi:10.3390/ijms23010535. PMID: 35008958

 

Integrated multi-omics analysis of RB-loss identifies widespread cellular programming and synthetic weaknesses.

Rajasekaran S, Siddiqui J, Rakijas J, Nicolay B, Lin C, Khan E, Patel R, Morris R, Wyler E, Boukhali M, Balasubramanyam J, Ranjith Kumar R, Van Rechem C, Vogel C, Elchuri SV, Landthaler M, Obermayer B, Haas W, Dyson N, Miles W. Communications Biology. 2021 Aug 17;4(1):977. doi: 10.1038/s42003-021-02495-2.PMID: 34404904 Free PMC article.

 

RNA editing signatures identify melanoma patients who respond to Pembrolizumab or Nivolumab treatment.

Siddiqui J, Miles WO. Translation Oncology. 2021 Nov;14(11):101197. doi: 10.1016/j.tranon.2021.101197. Epub 2021 Aug 10.PMID: 34388693

 

Thermostability, Tunability, and Tenacity of RNA as Rubbery Anionic Polymeric Materials in Nanotechnology and Nanomedicine-Specific Cancer Targeting with Undetectable Toxicity.

Binzel DW, Li X, Burns N, Khan E, Lee WJ, Chen LC, Ellipilli S, Miles W, Ho YS, Guo P. ACS Chemical Reviews. 2021 Jul 14;121(13):7398-7467. doi: 10.1021/acs.chemrev.1c00009. Epub 2021 May 26.PMID: 34038115

 

Comprehensive Analysis of MEN1 Mutations and Their Role in Cancer.

Nelakurti DD, Pappula AL, Rajasekaran S, Miles WO, Petreaca RC. Cancers (Basel). 2020 Sep 14;12(9):E2616. doi: 10.3390/cancers12092616.

 

Inactivation of Fbxw7 Impairs dsRNA Sensing and Confers Resistance to PD-1 Blockade.

Gstalder C, Liu D, Miao D, Lutterbach B, DeVine AL, Lin C, Shettigar M, Pancholi P, Buchbinder EI, Carter SL, Manos MP, Rojas-Rudilla V, Brennick R, Gjini E, Chen PH, Lako A, Rodig S, Yoon CH, Freeman GJ, Barbie DA, Hodi FS, Miles W, Van Allen EM, Haq R. Cancer Discovery. 2020 Sep;10(9):1296-1311. doi: 10.1158/2159-8290.CD-19-1416. Epub 2020 May 5.

 

Destabilization of NOXA mRNA as a common resistance mechanism to targeted therapies.

Montero J, Gstalder C, Kim DJ, Sadowicz D, Miles W, Manos M, Cidado JR, Paul Secrist J, Tron AE, Flaherty K, Stephen Hodi F, Yoon CH, Letai A, Fisher DE, Haq R. Nature Communications. 2019 Nov 14;10(1):5157. doi: 10.1038/s41467-019-12477-y.

 

Beyond CLIP: advances and opportunities to measure RBP-RNA and RNA-RNA interactions.

Lin C, Miles WO. Nucleic Acids Research. 2019 Jun 20;47(11):5490-5501. doi: 10.1093/nar/gkz295.

 

Non-coding and Coding Transcriptional Profiles Are Significantly Altered in Pediatric Retinoblastoma Tumors.

Rajasekaran S, Nagarajha Selvan LD, Dotts K, Kumar R, Rishi P, Khetan V, Bisht M, Sivaraman K, Krishnakumar S, Sahoo D, Campbell MJ, Elchuri SV, Miles WO. Frontiers in Oncology. 2019 Apr 16;9:221. doi: 10.3389/fonc.2019.00221. eCollection 2019.

 

Metabolite systems profiling identifies exploitable weaknesses in retinoblastoma.

Sahoo, S., Ravi Kumar, R.K., Nicolay, B., Mohite, O., Sivaraman, K., Khetan, V., Rishi, P., Ganesan, S., Subramanyan, K., Raman, K., Miles, W., and Elchuri, S.V.2019.  FEBS letters.

 

Transcriptional targeting of oncogene addiction in medullary thyroid cancer.

Valenciaga, A., Saji, M., Yu, L., Zhang, X., Bumrah, C., Yilmaz, A.S., Knippler, C.M., Miles, W., Giordano, T.J., Cote, G.J. and Ringel, M.D., 2018.  JCI insight, 3(16).

 

Proteogenomic analysis of surgically resected lung adenocarcinoma.

Sharpnack, M.F., Ranbaduge, N., Srivastava, A., Cerciello, F., Codreanu, S.G., Liebler, D.C., Mascaux, C., Miles, W.O., Morris, R., McDermott, J.E. and Sharpnack, J.L., 2018.  Journal of Thoracic Oncology, 13(10), pp.1519-1529.

 

RNA-sequencing of primary Retinoblastoma tumors provides new insights and challenges into tumor development.

Elchuri, S.V., Rajasekaran, S. and Miles, W.O., 2018. Frontiers in Genetics, 9.

 

Alternative polyadenylation in triple-negative breast tumors allows NRAS and c-JUN to bypass PUMILIO posttranscriptional regulation.

Miles, W.O., Lembo, A., Volorio, A., Brachtel, E., Tian, B., Sgroi, D., Provero, P. and Dyson, N., 2016. Cancer research, 76(24), pp.7231-7241.

 

The LSD1 family of histone demethylases and the pumilio posttranscriptional repressor function in a complex regulatory feedback loop.

Miles, W.O., Lepesant, J.M., Bourdeaux, J., Texier, M., Kerenyi, M.A., Nakakido, M., Hamamoto, R., Orkin, S.H., Dyson, N.J. and Di Stefano, L., 2015. Molecular and Cellular Biology, 35(24), pp.4199-4211.

 

Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation.

Nicolay, B.N., Danielian, P.S., Kottakis, F., Lapek, J.D., Sanidas, I., Miles, W.O., Dehnad, M., Tschöp, K., Gierut, J.J., Manning, A.L. and Morris, R., 2015. Genes & Development, 29(17), pp.1875-1889.

 

RB-loss puts focus on Myc.

Miles, W.O. and Dyson, N.J., 2015. Nature Cell Biology, 17(8), p.968.

 

Pumilio and nanos RNA-binding proteins counterbalance the transcriptional consequences of RB1 inactivation.

Miles, W.O. and Dyson, N.J., 2014. Molecular & Cellular Oncology, 1(4), p.e968074.

 

Post‐transcriptional gene expression control by NANOS is up‐regulated and functionally important in pRb‐deficient cells.

Miles, W.O., Korenjak, M., Griffiths, L.M., Dyer, M.A., Provero, P. and Dyson, N.J., 2014.  The EMBO journal, 33(19), pp.2201-2215.

 

In vivo regulation of E2F1 by Polycomb group genes in Drosophila.

Ji, J.Y., Miles, W.O., Korenjak, M., Zheng, Y. and Dyson, N.J., 2012. G3: Genes, Genomes, Genetics, 2(12), pp.1651-1660.

 

Pumilio facilitates miRNA regulation of the E2F3 oncogene.

Miles, W.O., Tschöp, K., Herr, A., Ji, J.Y. and Dyson, N.J., 2012. Genes & Development, 26(4), pp.356-368.

 

Modeling tumor invasion and metastasis in Drosophila.

Miles, W.O., Dyson, N.J. and Walker, J.A., 2011. Disease models & mechanisms, 4(6), pp.753-761.

 

Medea SUMOylation restricts the signaling range of the Dpp morphogen in the Drosophila embryo.

Miles, W.O., Jaffray, E., Campbell, S.G., Takeda, S., Bayston, L.J., Basu, S.P., Li, M., Raftery, L.A., Ashe, M.P., Hay, R.T. and Ashe, H.L., 2008. Genes & Development, 22(18), pp.2578-2590.