Publications

Integrated multi-omics analysis of RB-loss identifies widespread cellular programming and synthetic weaknesses.

Rajasekaran S, Siddiqui J, Rakijas J, Nicolay B, Lin C, Khan E, Patel R, Morris R, Wyler E, Boukhali M, Balasubramanyam J, Ranjith Kumar R, Van Rechem C, Vogel C, Elchuri SV, Landthaler M, Obermayer B, Haas W, Dyson N, Miles W. Communications Biology. 2021 Aug 17;4(1):977. doi: 10.1038/s42003-021-02495-2.PMID: 34404904 Free PMC article.

 

RNA editing signatures identify melanoma patients who respond to Pembrolizumab or Nivolumab treatment.

Siddiqui J, Miles WO. Translation Oncology. 2021 Nov;14(11):101197. doi: 10.1016/j.tranon.2021.101197. Epub 2021 Aug 10.PMID: 34388693

 

Thermostability, Tunability, and Tenacity of RNA as Rubbery Anionic Polymeric Materials in Nanotechnology and Nanomedicine-Specific Cancer Targeting with Undetectable Toxicity.

Binzel DW, Li X, Burns N, Khan E, Lee WJ, Chen LC, Ellipilli S, Miles W, Ho YS, Guo P. ACS Chemical Reviews. 2021 Jul 14;121(13):7398-7467. doi: 10.1021/acs.chemrev.1c00009. Epub 2021 May 26.PMID: 34038115

 

Comprehensive Analysis of MEN1 Mutations and Their Role in Cancer.

Nelakurti DD, Pappula AL, Rajasekaran S, Miles WO, Petreaca RC. Cancers (Basel). 2020 Sep 14;12(9):E2616. doi: 10.3390/cancers12092616.

 

Inactivation of Fbxw7 Impairs dsRNA Sensing and Confers Resistance to PD-1 Blockade.

Gstalder C, Liu D, Miao D, Lutterbach B, DeVine AL, Lin C, Shettigar M, Pancholi P, Buchbinder EI, Carter SL, Manos MP, Rojas-Rudilla V, Brennick R, Gjini E, Chen PH, Lako A, Rodig S, Yoon CH, Freeman GJ, Barbie DA, Hodi FS, Miles W, Van Allen EM, Haq R. Cancer Discovery. 2020 Sep;10(9):1296-1311. doi: 10.1158/2159-8290.CD-19-1416. Epub 2020 May 5.

 

Destabilization of NOXA mRNA as a common resistance mechanism to targeted therapies.

Montero J, Gstalder C, Kim DJ, Sadowicz D, Miles W, Manos M, Cidado JR, Paul Secrist J, Tron AE, Flaherty K, Stephen Hodi F, Yoon CH, Letai A, Fisher DE, Haq R. Nature Communications. 2019 Nov 14;10(1):5157. doi: 10.1038/s41467-019-12477-y.

 

Beyond CLIP: advances and opportunities to measure RBP-RNA and RNA-RNA interactions.

Lin C, Miles WO. Nucleic Acids Research. 2019 Jun 20;47(11):5490-5501. doi: 10.1093/nar/gkz295.

 

Non-coding and Coding Transcriptional Profiles Are Significantly Altered in Pediatric Retinoblastoma Tumors.

Rajasekaran S, Nagarajha Selvan LD, Dotts K, Kumar R, Rishi P, Khetan V, Bisht M, Sivaraman K, Krishnakumar S, Sahoo D, Campbell MJ, Elchuri SV, Miles WO. Frontiers in Oncology. 2019 Apr 16;9:221. doi: 10.3389/fonc.2019.00221. eCollection 2019.

 

Metabolite systems profiling identifies exploitable weaknesses in retinoblastoma.

Sahoo, S., Ravi Kumar, R.K., Nicolay, B., Mohite, O., Sivaraman, K., Khetan, V., Rishi, P., Ganesan, S., Subramanyan, K., Raman, K., Miles, W., and Elchuri, S.V.2019.  FEBS letters.

 

Transcriptional targeting of oncogene addiction in medullary thyroid cancer.

Valenciaga, A., Saji, M., Yu, L., Zhang, X., Bumrah, C., Yilmaz, A.S., Knippler, C.M., Miles, W., Giordano, T.J., Cote, G.J. and Ringel, M.D., 2018.  JCI insight, 3(16).

 

Proteogenomic analysis of surgically resected lung adenocarcinoma.

Sharpnack, M.F., Ranbaduge, N., Srivastava, A., Cerciello, F., Codreanu, S.G., Liebler, D.C., Mascaux, C., Miles, W.O., Morris, R., McDermott, J.E. and Sharpnack, J.L., 2018.  Journal of Thoracic Oncology13(10), pp.1519-1529.

 

RNA-sequencing of primary Retinoblastoma tumors provides new insights and challenges into tumor development.

Elchuri, S.V., Rajasekaran, S. and Miles, W.O., 2018. Frontiers in Genetics9.

 

Alternative polyadenylation in triple-negative breast tumors allows NRAS and c-JUN to bypass PUMILIO posttranscriptional regulation.

Miles, W.O., Lembo, A., Volorio, A., Brachtel, E., Tian, B., Sgroi, D., Provero, P. and Dyson, N., 2016. Cancer research76(24), pp.7231-7241.

 

The LSD1 family of histone demethylases and the pumilio posttranscriptional repressor function in a complex regulatory feedback loop.

Miles, W.O., Lepesant, J.M., Bourdeaux, J., Texier, M., Kerenyi, M.A., Nakakido, M., Hamamoto, R., Orkin, S.H., Dyson, N.J. and Di Stefano, L., 2015. Molecular and Cellular Biology, 35(24), pp.4199-4211.

 

Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation.

Nicolay, B.N., Danielian, P.S., Kottakis, F., Lapek, J.D., Sanidas, I., Miles, W.O., Dehnad, M., Tschöp, K., Gierut, J.J., Manning, A.L. and Morris, R., 2015. Genes & Development, 29(17), pp.1875-1889.

 

RB-loss puts focus on Myc.

Miles, W.O. and Dyson, N.J., 2015. Nature Cell Biology17(8), p.968.

 

Pumilio and nanos RNA-binding proteins counterbalance the transcriptional consequences of RB1 inactivation.

Miles, W.O. and Dyson, N.J., 2014. Molecular & Cellular Oncology1(4), p.e968074.

 

Post‐transcriptional gene expression control by NANOS is up‐regulated and functionally important in pRb‐deficient cells.

Miles, W.O., Korenjak, M., Griffiths, L.M., Dyer, M.A., Provero, P. and Dyson, N.J., 2014.  The EMBO journal, 33(19), pp.2201-2215.

 

In vivo regulation of E2F1 by Polycomb group genes in Drosophila.

Ji, J.Y., Miles, W.O., Korenjak, M., Zheng, Y. and Dyson, N.J., 2012. G3: Genes, Genomes, Genetics, 2(12), pp.1651-1660.

 

Pumilio facilitates miRNA regulation of the E2F3 oncogene.

Miles, W.O., Tschöp, K., Herr, A., Ji, J.Y. and Dyson, N.J., 2012. Genes & Development26(4), pp.356-368.

 

Modeling tumor invasion and metastasis in Drosophila.

Miles, W.O., Dyson, N.J. and Walker, J.A., 2011. Disease models & mechanisms4(6), pp.753-761.

 

Medea SUMOylation restricts the signaling range of the Dpp morphogen in the Drosophila embryo.

Miles, W.O., Jaffray, E., Campbell, S.G., Takeda, S., Bayston, L.J., Basu, S.P., Li, M., Raftery, L.A., Ashe, M.P., Hay, R.T. and Ashe, H.L., 2008. Genes & Development22(18), pp.2578-2590.