Wayne Miles, Ph. D – Principal Investigator
Post-Doctoral Fellowship with Professor Nicholas Dyson, Harvard Medical School and Massachusetts General Hospital Cancer Center.
Ph.D. in Developmental Biology from the University of Manchester, U.K., under the supervision of Professor Hilary Ashe
Chenyu Lin, Ph. D – Postdoctoral Research Associate
My research focus on post-transcriptional regulation factors such as global system identification of RBPs, RNA antisense capture assay, RNA secondary structure technologies and CRISPR drop out screens. To unveil the extensive interactions between RBPs and/or RNA structure, my research tries to improve current technology via integrating multiple methods to expand versatility of RNA roles in diverse molecular system.
Jalal Siddiqui, Ph. D – Postdoctoral Research Associate
I received a BA in Biology (with a program of study in Computational Biology) as well as a BS and M.Eng in Chemical Engineering from Cornell University. Following this, I earned a PhD in Biophysics at The Ohio State University in the Biophysics Graduate Program under Dr. Jonathan Davis. During my PhD training, I focused on understanding the role of calcium binding proteins in cardiac physiology and disease utilising both experimental and computational methods. During my postdoctoral training (2017-2019) under Dr. Ewy Mathé, I focused on developing computational tools integrate multi-omics datasets (metabolomics, transcriptomics, microbiome). My work in the Miles lab focuses on developing bioinformatics pipelines and conducting bioinformatics analyses on cancer datasets.
Eshan Khan, Ph. D – Postdoctoral Research Associate
I received my PhD at Indian Institute of Technology, Indore. My research in Miles lab focus on post transcriptional and translational regulation in cancer. My research includes the biophysical and structural characterization of RNA-protein interactions during post-transcription. My research also unveils different Non-AUG dependent translation mechanisms in Cancer. My present work will provide better understanding of RNA-protein interactions during post-transcription as well as explore the novel factors involved in Non-AUG dependent translation during cancer progression.
Swetha Rajasekaran, Graduate Research Fellow
I received my B. Tech degree in Biotechnology from SRM University, Chennai. I joined the Miles lab in January, 2017. My research focuses on post-transcriptional regulation with a specific interest in RNA-binding proteins. My favorite RNA-binding protein is Pumilio! I would like to try and understand the role played by Pumilio in post-transcriptional regulation, specifically in cancer. My long-term goal is to understand why cells require Pumilio proteins for normal function, how it can cope with the loss of these proteins, and the kinetics of this RNA-binding protein.
Raleigh Kladney – Research Assistant
I am currently working on generating RNA-seq and ribosome profiling data on RPE cell lines that have had several tumor suppressor genes knocked out by CRISPR. I am also generating this data on several HNSCC cell lines with various mutations negatively effecting tumor suppressors as well.