Publications

Peer-reviewed research publications (2005-date):

• Nieto-Panqueva, F., Rubalcava-Gracia. D., Hamel, P., and González-Halphen D. (2023) The constraints of allotopic expression. Mitochondrion, 73, 30-50. 

• Subrahmanian, N., Castonguay, A.D., Remacle C., and Hamel P. (2020) Assembly of complex I requires AMC1, a low-complexity protein, is required for mitochondrial complex I biogenesis in Chlamydomonas reinhardtii. Genetics, 214, 895-911.
• Subrahmanian, N., Castonguay, A.D., Apelsund Fatnes T., and Hamel P. (2020) Chlamydomonas reinhardtii as a platform to study mitochondrial complex I dysfunction. Plant Direct, 4, 1-16.
• Rubalcava-Gracia. D., García-Rincón, J., Pérez-Montfort, R., Hamel, P. and González-Halphen D. (2019). Key within-membrane residues and precursor dosage impact the allotopic expression of yeast subunit II of cytochrome c oxidase. Mol. Biol. Cell, 30, 2349-2434.
• Cline, S.G., Laughenbaum, I.A. and Hamel, P. (2017) CCS2, an octatricopeptide-repeat protein is required for plastid cytochrome c assembly in the green alga Chlamydomonas reinhardtii. Front. Plant Sci., 8, 1306.
• Duarte-Sanmiguel S., Arango, D., Parihar A., Hamel, P., Rumana, Y and Doseff A. (2013) Apigenin protects LPS-induced inflammation in endothelial cells by inhibition of caspase-3 and modulation of mitochondrial complex I activity.
  Int. J. Mol. Sci., 14, 17664-17679.
• Soto, I. C., Fontanesi, F., Myers, R. S., Hamel, P. and Barrientos, A. (2012) A Heme-sensing mechanism in the translational regulation of mitochondrial cytochrome c oxidase biogenesis. Cell Metab., 16, 801-813.
• Corvest, V., Murray, D.A., Hirasawa, M., Knaff, D.B., Guiard, B. and Hamel, P. (2012) The flavoprotein Cyc2p, a mitochondrial cytochrome c assembly factor, is a NAD(P)H-dependent heme reductase. Mol. Microbiol., 83, 968-980.
• Karamoko, M., Cline., S. Redding, K., Ruiz, N. and Hamel, P. (2011) Lumen Thiol Oxidoreductase 1, a disulfide bond forming catalyst, is required for the assembly of photosystem II in Arabidopsis. Plant Cell, 23, 4462-4475.
• Barbieri, M.R., Larosa, V., Nouet, C., Subrahmanian, N., Remacle, C. Hamel, P. (2011) A Forward Genetic Screen Identifies Mutants Deficient for Mitochondrial Complex I Assembly in Chlamydomonas reinhardtii. Genetics, 188, 349-358.
• Gabilly, S., Kropat, J., Karamoko, M., Page, M.D., Nakamoto, S., Merchant, S. and Hamel, P. (2011) A Novel Component of the Disulfide-Reducing Pathway Required for Cytochrome c Assembly in Plastids. Genetics, 187, 793-802. 
• Gabilly, S., Dreyfuss, B., Karamoko, M., Corvest, V., Kropat, J., Page, M.D., Merchant S. and Hamel, P. (2010) CCS5, a Thioredoxin-like Protein Involved in the Assembly of Plastid c-Type Cytochromes. J. Biol. Chem., 285, 29738-29749. 
• Reynolds, N. M., Ling, J., Roy, H., Banerjee, R., Repasky, S., Hamel, P. and Ibba, M. (2010) Cell-specific differences in the requirements for translation quality control. PNAS, 107, 4063-4068. 
• Corvest, V., Murray, D.A., Bernard, D.G., Knaff, D.B., Guiard, B and Hamel, P. (2010) c -Type Cytochrome Assembly in Saccharomyces cerevisiae: A Key Residue for Apocytochrome c1/Lyase Interaction. Genetics, 186, 561-571.
• Remacle C., Cline S., Boutafalla L., Gabilly S., Larosa V., Barbieri, M. R., and Hamel P. (2009) The ARG9 Gene Encodes the Plastid-Resident N-Acetyl Ornithine Aminotransferase in the Green Alga Chlamydomonas reinhardtii. Eukaryotic Cell, 9, 1460–1463.
• Bernard, D., Quevillon-Cheruel S., Merchant, S., Guiard, B. and Hamel, P. (2005) Cyc2p, a membrane-bound flavoprotein involved in the maturation of mitochondrial c-type cytochromes. J. Biol. Chem., 280, 39852-398549.

Published reviews (2005- date):

• Gabilly, S. and Hamel, P. (2017) Plastid cytochrome c maturation. Front Plant Sci., 8, 1313.
• Subrahmanian N., Remacle C. and Hamel, P. (2016) Plant mitochondrial Complex I composition and assembly: a review. Biochim. Biophys. Acta., 1857, 1001-14.
• Karamoko, M., Gabilly, S. and Hamel, P. (2013) Operation of trans-thylakoid thiol-metabolizing pathways in photosynthesis. Front. Plant Sci., 4, 476.
• Bonnard, G., Corvest, V., Meyer, E. and Hamel, P. (2010) Redox processes controlling the biogenesis of c-type cytochromes. Antioxid. Redox Signal., 13, 1385-1401. 
• Hamel P., Corvest, V., Giegé P and Bonnard G. (2009). Biochemical requirements for the maturation of mitochondrial c-type cytochromes. Biochim. Biophys. Acta, 1793, 125-138.
• Remacle C., Barbieri, R., Cardol P., and Hamel, P. (2008) Eukaryotic complex I: functional diversity and experimental systems to unravel the assembly process. Mol. Genet. Genomics., 280, 93-110. 

Published book chapters (2005-date):

• Hamel, P., Salinas Giegé T., Przybyla-Toscano, J., Caccamo, A., Subrahmanian, N., Rouhier, N., Drouard, L., Cardol, P., Gonzalez-Halphen, D., and Remacle, C. (2023). The mitochondrion: from genome to proteome in “The Chlamydomonas Sourcebook, 3^rd edition, Organellar and Metabolic processes, vol. 2 (Eds. A. Grossman and F.-A. Wollman, Publisher: Elsevier Inc.).”
• Das, A. and Hamel, P. (2021) Cytochrome c assembly in “Encyclopedia of Biological Chemistry, 3^rd edition (Ed. Joseph M. Jez, Publisher: Elsevier Inc.).” 
• Cline, S., Gabilly, S., Subrahmanian, N., and Hamel, P. (2016) Co-factor assembly of bc₁ and b₆f complexes in “Cytochrome Complexes: Evolution, Structures, Energy Transduction, and Signaling (Eds. T. Kallas and W. Cramer, Publisher: Springer).”
• Remacle, C., Hamel, P., Larosa, V., Subrahmanian, N,. and Cardol, P. (2012) Complexes I in the green lineage in “A structural perspective on respiratory complex I (Ed. L. Sazanov, Publisher: Springer).” 
• Remacle C., Hamel, P., Larosa, V., Thalia, S., Subrahmanian, N., Bonnefoy, N., and Kempken F. (2012) Transformation and delivery of nucleic acid to mitochondria in “Genomics of chloroplasts and mitochondria, Advances in photosynthesis and respiration (Eds. R. Bock and V. Knoop, Publisher: Springer).” 
• Hanikenne M., Merchant, S. and Hamel, P. (2009) Transition metal nutrition: a balance between deficiency and toxicity in “The Chlamydomonas Sourcebook, second edition, Organellar and Metabolic processes, vol. 2 (Eds. Harris, D.B. Stern, and G.B. Witman, Publisher: Academic Press).”

Patrice Hamel’s Personal Post-Doc and Graduate Publications (click here)