Publications | Nutrient & Phytochemical Analytics Shared Resource (NPASR)

Berry – phenolic acids, flavonoids, procyanidins, ellagitannins, urolithins

Roberts, K. M.; Grainger, E. M.; Thomas-Ahner, J. M.; Hinton, A.; Gu, J.; Riedl, K.; Vodovotz, Y.; Abaza, R.; Schwartz, S. J.; Clinton, S. K. Dose-Dependent Increases in Ellagitannin Metabolites as Biomarkers of Intake in Humans Consuming Standardized Black Raspberry Food Products Designed for Clinical Trials. Molecular nutrition & food research [Online] 2020, e1900800.

*Gu, J.; Thomas-Ahner, J. M.; Riedl, K. M.; Bailey, M. T.; Vodovotz, Y.; Schwartz, S. J.; Clinton, S. K. Dietary Black Raspberries Impact the Colonic Microbiome and Phytochemical Metabolites in Mice. Molecular nutrition & food research 2019, 63 (8), e1800636. DOI: 10.1002/mnfr.201800636.

*Sasaki, G. Y.; Li, J.; Cichon, M. J.; Riedl, K. M.; Kopec, R. E.; Bruno, R. S. Green Tea Extract Treatment in Obese Mice with Nonalcoholic Steatohepatitis Restores the Hepatic Metabolome in Association with Limiting Endotoxemia-TLR4-NFκB-Mediated Inflammation. Molecular nutrition & food research 2019, 63 (24), e1900811. DOI: 10.1002/mnfr.201900811

*Roberts, K. M.; Grainger, E. M.; Thomas-Ahner, J. M.; Hinton, A.; Gu, J.; Riedl, K. M.; Vodovotz, Y.; Abaza, R.; Schwartz, S. J.; Clinton, S. K. Application of a low polyphenol or low ellagitannin dietary intervention and its impact on ellagitannin metabolism in men. Molecular nutrition & food research 2017, 61 (3). DOI: 10.1002/mnfr.201600224.

Shi, N.; Riedl, K. M.; Schwartz, S. J.; Zhang, X.; Clinton, S. K.; Chen, T. Efficacy comparison of lyophilised black raspberries and combination of celecoxib and PBIT in prevention of carcinogen-induced oesophageal cancer in rats. Journal of functional foods 2016, 27, 84–94. DOI: 10.1016/j.jff.2016.08.044.

*Shi, N.; Clinton, S. K.; Liu, Z.; Wang, Y.; Riedl, K. M.; Schwartz, S. J.; Zhang, X.; Pan, Z.; Chen, T. Strawberry phytochemicals inhibit azoxymethane/dextran sodium sulfate-induced colorectal carcinogenesis in Crj: CD-1 mice. Nutrients 2015, 7 (3), 1696–1715. DOI: 10.3390/nu7031696.

Gu, J.; Ahn-Jarvis, J. H.; Riedl, K. M.; Schwartz, S. J.; Clinton, S. K.; Vodovotz, Y. Characterization of black raspberry functional food products for cancer prevention human clinical trials. Journal of agricultural and food chemistry 2014, 62 (18), 3997–4006. DOI: 10.1021/jf404566p.

Mace, T. A.; King, S. A.; Ameen, Z.; Elnaggar, O.; Young, G.; Riedl, K. M.; Schwartz, S. J.; Clinton, S. K.; Knobloch, T. J.; Weghorst, C. M.; Lesinski, G. B. Bioactive compounds or metabolites from black raspberries modulate T lymphocyte proliferation, myeloid cell differentiation and Jak/STAT signaling. Cancer immunology, immunotherapy : CII 2014, 63 (9), 889–900. DOI: 10.1007/s00262-014-1564-5.

Hostetler, G. L.; Riedl, K. M.; Schwartz, S. J. Effects of food formulation and thermal processing on flavones in celery and chamomile. Food chemistry 2013, 141 (2), 1406–1411. DOI: 10.1016/j.foodchem.2013.04.051 .

Paudel, L.; Wyzgoski, F. J.; Scheerens, J. C.; Chanon, A. M.; Reese, R. N.; Smiljanic, D.; Wesdemiotis, C.; Blakeslee, J. J.; Riedl, K. M.; Rinaldi, P. L. Nonanthocyanin secondary metabolites of black raspberry (Rubus occidentalis L.) fruits: identification by HPLC-DAD, NMR, HPLC-ESI-MS, and ESI-MS/MS analyses. Journal of agricultural and food chemistry 2013, 61 (49), 12032–12043. DOI: 10.1021/jf4039953.

Hostetler, G. L.; Riedl, K. M.; Schwartz, S. J. Endogenous enzymes, heat, and pH affect flavone profiles in parsley (Petroselinum crispum var. neapolitanum) and celery (Apium graveolens) during juice processing. Journal of agricultural and food chemistry 2012, 60 (1), 202–208. DOI: 10.1021/jf2033736

Kamonpatana, K.; Giusti, M. M.; Chitchumroonchokchai, C.; MorenoCruz, M.; Riedl, K. M.; Kumar, P.; Failla, M. L. Susceptibility of anthocyanins to ex vivo degradation in human saliva. Food chemistry 2012, 135 (2), 738–747. DOI: 10.1016/j.foodchem.2012.04.110.

Broccoli – glucosinolates, isothiocyanates, and isothiocyanate conjugates (glutathione, cysteinyl glycine, cysteine, N-acetyl cysteine)

*Abbaoui, B.; Lucas, C. R.; Riedl, K. M.; Clinton, S. K.; Mortazavi, A. Cruciferous Vegetables, Isothiocyanates, and Bladder Cancer Prevention. Molecular nutrition & food research 2018, 62 (18), e1800079. DOI: 10.1002/mnfr.201800079.

Westphal, A.; Riedl, K. M.; Cooperstone, J. L.; Kamat, S.; Balasubramaniam, V. M.; Schwartz, S. J.; Böhm, V. High-Pressure Processing of Broccoli Sprouts: Influence on Bioactivation of Glucosinolates to Isothiocyanates. Journal of agricultural and food chemistry 2017, 65 (39), 8578–8585. DOI: 10.1021/acs.jafc.7b01380.

Bricker, G. V.; Riedl, K. M.; Ralston, R. A.; Tober, K. L.; Oberyszyn, T. M.; Schwartz, S. J. Isothiocyanate metabolism, distribution, and interconversion in mice following consumption of thermally processed broccoli sprouts or purified sulforaphane. Molecular nutrition & food research 2014, 58 (10), 1991–2000. DOI: 10.1002/mnfr.201400104.

Abbaoui, B.; Riedl, K. M.; Ralston, R. A.; Thomas-Ahner, J. M.; Schwartz, S. J.; Clinton, S. K.; Mortazavi, A. Inhibition of bladder cancer by broccoli isothiocyanates sulforaphane and erucin: characterization, metabolism, and interconversion. Molecular nutrition & food research 2012, 56 (11), 1675–1687. DOI: 10.1002/mnfr.201200276.

Clarke, J. D.; Hsu, A.; Riedl, K.; Bella, D.; Schwartz, S. J.; Stevens, J. F.; Ho, E. Bioavailability and inter-conversion of sulforaphane and erucin in human subjects consuming broccoli sprouts or broccoli supplement in a cross-over study design. Pharmacological research : the official journal of the Italian Pharmacological Society 2011, 64 (5), 456–463. DOI: 10.1016/j.phrs.2011.07.005.

Clarke, J. D.; Riedl, K.; Bella, D.; Schwartz, S. J.; Stevens, J. F.; Ho, E. Comparison of isothiocyanate metabolite levels and histone deacetylase activity in human subjects consuming broccoli sprouts or broccoli supplement. Journal of agricultural and food chemistry 2011, 59 (20), 10955–10963. DOI: 10.1021/jf202887c.

Soy – isoflavones and saponins

Grainger, E. M.; Moran, N. E.; Francis, D. M.; Schwartz, S. J.; Wan, L.; Thomas-Ahner, J.; Kopec, R. E.; Riedl, K. M.; Young, G. S.; Abaza, R.; Bahnson, R. R.; Clinton, S. K. A Novel Tomato-Soy Juice Induces a Dose-Response Increase in Urinary and Plasma Phytochemical Biomarkers in Men with Prostate Cancer. The Journal of nutrition 2019, 149 (1), 26–35. DOI: 10.1093/jn/nxy232. (also in Tomato – carotenoids, apo-carotenoids, alkaloids)

*Ahn-Jarvis, J. H.; Clinton, S. K.; Grainger, E. M.; Riedl, K. M.; Schwartz, S. J.; Lee, M.-L. T.; Cruz-Cano, R.; Young, G. S.; Lesinski, G. B.; Vodovotz, Y. Isoflavone pharmacokinetics and metabolism after consumption of a standardized soy and soy-almond bread in men with asymptomatic prostate cancer. Cancer prevention research (Philadelphia, Pa.) 2015, 8 (11), 1045–1054. DOI: 10.1158/1940-6207.CAPR-14-0465.

Ahn-Jarvis, J. H.; Riedl, K. M.; Schwartz, S. J.; Vodovotz, Y. Design and selection of soy breads used for evaluating isoflavone bioavailability in clinical trials. Journal of agricultural and food chemistry 2013, 61 (12), 3111–3120. DOI: 10.1021/jf304699k.

Serventi, L.; Chitchumroonchokchai, C.; Riedl, K. M.; Kerem, Z.; Berhow, M. A.; Vodovotz, Y.; Schwartz, S. J.; Failla, M. L. Saponins from soy and chickpea: stability during beadmaking and in vitro bioaccessibility. Journal of agricultural and food chemistry 2013, 61 (27), 6703–6710. DOI: 10.1021/jf401597y.

*Ahn-Jarvis, J.; Clinton, S. K.; Riedl, K. M.; Vodovotz, Y.; Schwartz, S. J. Impact of food matrix on isoflavone metabolism and cardiovascular biomarkers in adults with hypercholesterolemia. Food & function 2012, 3 (10), 1051–1058. DOI: 10.1039/c2fo10284f.

Tomato – carotenoids, apo-carotenoids, alkaloids

Durojaye, B. O.; Riedl, K. M.; Curley, R. W.; Harrison, E. H. Uptake and metabolism of β-apo-8′-carotenal, β-apo-10′-carotenal, and β-apo-13-carotenone in Caco-2 cells. Journal of lipid research 2019, 60 (6), 1121–1135. DOI: 10.1194/jlr.M093161.

Dzakovich, M. P.; Gas-Pascual, E.; Orchard, C. J.; Sari, E. N.; Riedl, K. M.; Schwartz, S. J.; Francis, D. M.; Cooperstone, J. L. Analysis of Tomato Carotenoids: Comparing Extraction and Chromatographic Methods. Journal of AOAC International 2019, 102 (4), 1069–1079. DOI: 10.5740/jaoacint.19-0017.

Moran, N. E.; Thomas-Ahner, J. M.; Fleming, J. L.; McElroy, J. P.; Mehl, R.; Grainger, E. M.; Riedl, K. M.; Toland, A. E.; Schwartz, S. J.; Clinton, S. K. Single Nucleotide Polymorphisms in β-Carotene Oxygenase 1 are Associated with Plasma Lycopene Responses to a Tomato-Soy Juice Intervention in Men with Prostate Cancer. The Journal of nutrition 2019, 149 (3), 381–397. DOI: 10.1093/jn/nxy304.

Cichon, M. J.; Moran, N. E.; Riedl, K. M.; Schwartz, S. J.; Clinton, S. K. Identification of an Epoxide Metabolite of Lycopene in Human Plasma Using 13C-Labeling and QTOF-MS. Metabolites 2018, 8 (1). DOI: 10.3390/metabo8010024.

Cooperstone, J. L.; Novotny, J. A.; Riedl, K. M.; Cichon, M. J.; Francis, D. M.; Curley, R. W.; Schwartz, S. J.; Harrison, E. H. Limited appearance of apocarotenoids is observed in plasma after consumption of tomato juices: a randomized human clinical trial. The American journal of clinical nutrition 2018, 108 (4), 784–792. DOI: 10.1093/ajcn/nqy177.

Cichon, M. J.; Riedl, K. M.; Schwartz, S. J. A metabolomic evaluation of the phytochemical composition of tomato juices being used in human clinical trials. Food chemistry 2017, 228, 270–278. DOI: 10.1016/j.foodchem.2017.01.118.

Cichon, M. J.; Riedl, K. M.; Wan, L.; Thomas-Ahner, J. M.; Francis, D. M.; Clinton, S. K.; Schwartz, S. J. Plasma Metabolomics Reveals Steroidal Alkaloids as Novel Biomarkers of Tomato Intake in Mice. Molecular nutrition & food research 2017, 61 (12). DOI: 10.1002/mnfr.201700241.

Cooperstone, J. L.; Goetz, H. J.; Riedl, K. M.; Harrison, E. H.; Schwartz, S. J.; Kopec, R. E. Relative contribution of α-carotene to postprandial vitamin A concentrations in healthy humans after carrot consumption. The American journal of clinical nutrition 2017, 106 (1), 59–66. DOI: 10.3945/ajcn.116.150821.

Cooperstone, J. L.; Tober, K. L.; Riedl, K. M.; Teegarden, M. D.; Cichon, M. J.; Francis, D. M.; Schwartz, S. J.; Oberyszyn, T. M. Tomatoes protect against development of UV-induced keratinocyte carcinoma via metabolomic alterations. Scientific reports 2017, 7 (1), 5106. DOI: 10.1038/s41598-017-05568-7.

Dela Seña, C.; Sun, J.; Narayanasamy, S.; Riedl, K. M.; Yuan, Y.; Curley, R. W.; Schwartz, S. J.; Harrison, E. H. Substrate Specificity of Purified Recombinant Chicken β-Carotene 9′,10′-Oxygenase (BCO2). The Journal of biological chemistry 2016, 291 (28), 14609–14619. DOI: 10.1074/jbc.M116.723684.

Goetz, H. J.; Kopec, R. E.; Riedl, K. M.; Cooperstone, J. L.; Narayanasamy, S.; Curley, R. W.; Schwartz, S. J. An HPLC-MS/MS method for the separation of α-retinyl esters from retinyl esters. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2016, 1029-1030, 68–71. DOI: 10.1016/j.jchromb.2016.06.043

Moran, N. E.; Novotny, J. A.; Cichon, M. J.; Riedl, K. M.; Rogers, R. B.; Grainger, E. M.; Schwartz, S. J.; Erdman, J. W.; Clinton, S. K. Absorption and Distribution Kinetics of the 13C-Labeled Tomato Carotenoid Phytoene in Healthy Adults. The Journal of nutrition 2016, 146 (2), 368–376. DOI: 10.3945/jn.115.220525.

Toomey, M. B.; Lind, O.; Frederiksen, R.; Curley, R. W.; Riedl, K. M.; Wilby, D.; Schwartz, S. J.; Witt, C. C.; Harrison, E. H.; Roberts, N. W.; Vorobyev, M.; McGraw, K. J.; Cornwall, M. C.; Kelber, A.; Corbo, J. C. Complementary shifts in photoreceptor spectral tuning unlock the full adaptive potential of ultraviolet vision in birds. eLife 2016, 5. DOI: 10.7554/eLife.15675.

Cooperstone, J. L.; Ralston, R. A.; Riedl, K. M.; Haufe, T. C.; Schweiggert, R. M.; King, S. A.; Timmers, C. D.; Francis, D. M.; Lesinski, G. B.; Clinton, S. K.; Schwartz, S. J. Enhanced bioavailability of lycopene when consumed as cis-isomers from tangerine compared to red tomato juice, a randomized, cross-over clinical trial. Molecular nutrition & food research 2015, 59 (4), 658–669. DOI: 10.1002/mnfr.201400658.

Grainger, E. M.; Hadley, C. W.; Moran, N. E.; Riedl, K. M.; Gong, M. C.; Pohar, K.; Schwartz, S. J.; Clinton, S. K. A comparison of plasma and prostate lycopene in response to typical servings of tomato soup, sauce or juice in men before prostatectomy. The British journal of nutrition 2015, 114 (4), 596–607. DOI: 10.1017/S0007114515002202.

Kopec, R. E.; Schick, J.; Tober, K. L.; Riedl, K. M.; Francis, D. M.; Young, G. S.; Schwartz, S. J.; Oberyszyn, T. M. Sex differences in skin carotenoid deposition and acute UVB-induced skin damage in SKH-1 hairless mice after consumption of tangerine tomatoes. Molecular nutrition & food research 2015, 59 (12), 2491–2501. DOI: 10.1002/mnfr.201500317.

Moran, N. E.; Cichon, M. J.; Riedl, K. M.; Grainger, E. M.; Schwartz, S. J.; Novotny, J. A.; Erdman, J. W.; Clinton, S. K. Compartmental and noncompartmental modeling of ¹³C-lycopene absorption, isomerization, and distribution kinetics in healthy adults. The American journal of clinical nutrition 2015, 102 (6), 1436–1449. DOI: 10.3945/ajcn.114.103143.

Dela Seña, C.; Riedl, K. M.; Narayanasamy, S.; Curley, R. W.; Schwartz, S. J.; Harrison, E. H. The human enzyme that converts dietary provitamin A carotenoids to vitamin A is a dioxygenase. The Journal of biological chemistry 2014, 289 (19), 13661–13666. DOI: 10.1074/jbc.M114.557710.

Tan, H.-L.; Moran, N. E.; Cichon, M. J.; Riedl, K. M.; Schwartz, S. J.; Erdman, J. W.; Pearl, D. K.; Thomas-Ahner, J. M.; Clinton, S. K. β-Carotene-9′,10′-oxygenase status modulates the impact of dietary tomato and lycopene on hepatic nuclear receptor-, stress-, and metabolism-related gene expression in mice. The Journal of nutrition 2014, 144 (4), 431–439. DOI: 10.3945/jn.113.186676.

Dela Seña, C.; Narayanasamy, S.; Riedl, K. M.; Curley, R. W.; Schwartz, S. J.; Harrison, E. H. Substrate specificity of purified recombinant human β-carotene 15,15′-oxygenase (BCO1). The Journal of biological chemistry 2013, 288 (52), 37094–37103. DOI: 10.1074/jbc.M113.507160.

Kopec, R. E.; Schweiggert, R. M.; Riedl, K. M.; Carle, R.; Schwartz, S. J. Comparison of high-performance liquid chromatography/tandem mass spectrometry and high-performance liquid chromatography/photo-diode array detection for the quantitation of carotenoids, retinyl esters, α-tocopherol and phylloquinone in chylomicron-rich fractions of human plasma. Rapid communications in mass spectrometry : RCM 2013, 27 (12), 1393–1402. DOI: 10.1002/rcm.6576.

Riedl, K. M.; Choksi, K.; Wyzgoski, F. J.; Scheerens, J. C.; Schwartz, S. J.; Reese, R. N. Variation in lycopene and lycopenoates, antioxidant capacity, and fruit quality of buffaloberry (Shepherdia argentea PurshNutt.). Journal of food science 2013, 78 (11), C1673-9. DOI: 10.1111/1750-3841.12265.

Eroglu, A.; Hruszkewycz, D. P.; dela Sena, C.; Narayanasamy, S.; Riedl, K. M.; Kopec, R. E.; Schwartz, S. J.; Curley, R. W.; Harrison, E. H. Naturally occurring eccentric cleavage products of provitamin A β-carotene function as antagonists of retinoic acid receptors. The Journal of biological chemistry 2012, 287 (19), 15886–15895. DOI: 10.1074/jbc.M111.325142.

Fleshman, M. K.; Riedl, K. M.; Novotny, J. A.; Schwartz, S. J.; Harrison, E. H. An LC/MS method for d8-β-carotene and d4-retinyl esters: β-carotene absorption and its conversion to vitamin A in humans. Journal of lipid research 2012, 53 (4), 820–827. DOI: 10.1194/jlr.D021139.

Garzón, G. A.; Narváez-Cuenca, C.-E.; Kopec, R. E.; Barry, A. M.; Riedl, K. M.; Schwartz, S. J. Determination of carotenoids, total phenolic content, and antioxidant activity of Arazá (Eugenia stipitata McVaugh), an Amazonian fruit. Journal of agricultural and food chemistry 2012, 60 (18), 4709–4717. DOI: 10.1021/jf205347f.

*Fleshman, M. K.; Lester, G. E.; Riedl, K. M.; Kopec, R. E.; Narayanasamy, S.; Curley, R. W.; Schwartz, S. J.; Harrison, E. H. Carotene and novel apocarotenoid concentrations in orange-fleshed Cucumis melo melons: determinations of β-carotene bioaccessibility and bioavailability. Journal of agricultural and food chemistry 2011, 59 (9), 4448–4454. DOI: 10.1021/jf200416a.

Kopec, R. E.; Riedl, K. M.; Harrison, E. H.; Curley, R. W.; Hruszkewycz, D. P.; Clinton, S. K.; Schwartz, S. J. Identification and quantification of apo-lycopenals in fruits, vegetables, and human plasma. Journal of agricultural and food chemistry 2010, 58 (6), 3290–3296. DOI: 10.1021/jf100415z.

LaFountain, A. M.; Kaligotla, S.; Cawley, S.; Riedl, K. M.; Schwartz, S. J.; Frank, H. A.; Prum, R. O. Novel methoxy-carotenoids from the burgundy-colored plumage of the Pompadour Cotinga Xipholena punicea. Archives of biochemistry and biophysics 2010, 504 (1), 142–153. DOI: 10.1016/j.abb.2010.08.006.

Shmarakov, I.; Fleshman, M. K.; D’Ambrosio, D. N.; Piantedosi, R.; Riedl, K. M.; Schwartz, S. J.; Curley, R. W.; Lintig, J. von; Rubin, L. P.; Harrison, E. H.; Blaner, W. S. Hepatic stellate cells are an important cellular site for β-carotene conversion to retinoid. Archives of biochemistry and biophysics 2010, 504 (1), 3–10. DOI: 10.1016/j.abb.2010.05.010.

Other Foods, Analytes and Lipidomics

Song, M.-A.; Reisinger, S. A.; Freudenheim, J. L.; Brasky, T. M.; Mathé, E. A.; McElroy, J. P.; Nickerson, Q. A.; Weng, D. Y.; Wewers, M. D.; Shields, P. G. Effects of Electronic Cigarette Constituents on the Human Lung: A Pilot Clinical Trial. Cancer prevention research (Philadelphia, Pa.) 2020, 13 (2), 145–152. DOI: 10.1158/1940-6207.CAPR-19-0400.

*Bowman, E. R.; Kulkarni, M.; Gabriel, J.; Cichon, M. J.; Riedl, K.; Belury, M. A.; Lake, J. E.; Richardson, B.; Cameron, C.; Cameron, M.; Koletar, S. L.; Lederman, M. M.; Sieg, S. F.; Funderburg, N. T. Altered Lipidome Composition Is Related to Markers of Monocyte and Immune Activation in Antiretroviral Therapy Treated Human Immunodeficiency Virus (HIV) Infection and in Uninfected Persons. Frontiers in immunology 2019, 10, 785. DOI: 10.3389/fimmu.2019.00785.

Sasaki, G. Y.; Li, J.; Cichon, M. J.; Riedl, K. M.; Kopec, R. E.; Bruno, R. S. Green Tea Extract Treatment in Obese Mice with Nonalcoholic Steatohepatitis Restores the Hepatic Metabolome in Association with Limiting Endotoxemia-TLR4-NFκB-Mediated Inflammation. Molecular nutrition & food research 2019, 63 (24), e1900811. DOI: 10.1002/mnfr.201900811.

Manubolu, M.; Lee, J.; Riedl, K. M.; Kua, Z. X.; Collart, L. P.; Ludsin, S. A. Optimization of extraction methods for quantification of microcystin-LR and microcystin-RR in fish, vegetable, and soil matrices using UPLC-MS/MS. Harmful algae 2018, 76, 47–57. DOI: 10.1016/j.hal.2018.04.009.

Aschoff, J. K.; Riedl, K. M.; Cooperstone, J. L.; Högel, J.; Bosy-Westphal, A.; Schwartz, S. J.; Carle, R.; Schweiggert, R. M. Urinary excretion of Citrus flavanones and their major catabolites after consumption of fresh oranges and pasteurized orange juice: A randomized cross-over study. Molecular nutrition & food research 2016, 60 (12), 2602–2610. DOI: 10.1002/mnfr.201600315.

Ke, J.-Y.; Cole, R. M.; Hamad, E. M.; Hsiao, Y.-H.; Cotten, B. M.; Powell, K. A.; Belury, M. A. Citrus flavonoid, naringenin, increases locomotor activity and reduces diacylglycerol accumulation in skeletal muscle of obese ovariectomized mice. Molecular nutrition & food research 2016, 60 (2), 313–324. DOI: 10.1002/mnfr.201500379.

Shen, Q.; Riedl, K. M.; Cole, R. M.; Lehman, C.; Xu, L.; Alder, H.; Belury, M. A.; Schwartz, S. J.; Ziouzenkova, O. Egg yolks inhibit activation of NF-κB and expression of its target genes in adipocytes after partial delipidation. Journal of agricultural and food chemistry 2015, 63 (7), 2013–2025. DOI: 10.1021/jf5056584.

Teegarden, M. D.; Riedl, K. M.; Schwartz, S. J. Chromatographic separation of PTAD-derivatized 25-hydroxyvitamin D3 and its C-3 epimer from human serum and murine skin. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2015, 991, 118–121. DOI: 10.1016/j.jchromb.2015.04.011.

Chitchumroonchokchai, C.; Thomas-Ahner, J. M.; Li, J.; Riedl, K. M.; Nontakham, J.; Suksumrarn, S.; Clinton, S. K.; Kinghorn, A. D.; Failla, M. L. Anti-tumorigenicity of dietary α-mangostin in an HT-29 colon cell xenograft model and the tissue distribution of xanthones and their phase II metabolites. Molecular nutrition & food research 2013, 57 (2), 203–211. DOI: 10.1002/mnfr.201200539.

*Chitchumroonchokchai, C.; Riedl, K. M.; Suksumrarn, S.; Clinton, S. K.; Kinghorn, A. D.; Failla, M. L. Xanthones in mangosteen juice are absorbed and partially conjugated by healthy adults. The Journal of nutrition 2012, 142 (4), 675–680. DOI: 10.3945/jn.111.156992.

Aparicio-Ruiz, R.; Riedl, K. M.; Schwartz, S. J. Identification and quantification of metallo-chlorophyll complexes in bright green table olives by high-performance liquid chromatrography-mass spectrometry quadrupole/time-of-flight. Journal of agricultural and food chemistry 2011, 59 (20), 11100–11108. DOI: 10.1021/jf201643s.

Wang, C.; Riedl, K. M.; Somerville, J.; Balasubramaniam, V. M.; Schwartz, S. J. Influence of high-pressure processing on the profile of polyglutamyl 5-methyltetrahydrofolate in selected vegetables. Journal of agricultural and food chemistry 2011, 59 (16), 8709–8717. DOI: 10.1021/jf201120n.

Lechner, J. F.; Wang, L.-S.; Rocha, C. M.; Larue, B.; Henry, C.; McIntyre, C. M.; Riedl, K. M.; Schwartz, S. J.; Stoner, G. D. Drinking water with red beetroot food color antagonizes esophageal carcinogenesis in N-nitrosomethylbenzylamine-treated rats. Journal of medicinal food 2010, 13 (3), 733–739. DOI: 10.1089/jmf.2008.0280.

Wang, C.; Riedl, K. M.; Schwartz, S. J. A liquid chromatography-tandem mass spectrometric method for quantitative determination of native 5-methyltetrahydrofolate and its polyglutamyl derivatives in raw vegetables. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2010, 878 (29), 2949–2958. DOI: 10.1016/j.jchromb.2010.08.043.

Expertise Instrumental to NPASR

Garzón, G. A.; Riedl, K. M.; Schwartz, S. J. Determination of anthocyanins, total phenolic content, and antioxidant activity in Andes Berry (Rubus glaucus Benth). Journal of food science 2009, 74 (3), C227-32. DOI: 10.1111/j.1750-3841.2009.01092.x.

Zikri, N. N.; Riedl, K. M.; Wang, L.-S.; Lechner, J.; Schwartz, S. J.; Stoner, G. D. Black raspberry components inhibit proliferation, induce apoptosis, and modulate gene expression in rat esophageal epithelial cells. Nutrition and cancer 2009, 61 (6), 816–826. DOI: 10.1080/01635580903285148.

Riedl, K. M.; Hagerman, A. E. Tannin-protein complexes as radical scavengers and radical sinks. Journal of agricultural and food chemistry 2001, 49 (10), 4917–4923. DOI: 10.1021/jf010683h.

Hagerman, A. E.; Riedl, K. M.; Jones, G. A.; Sovik, K. N.; Ritchard, N. T.; Hartzfeld, P. W.; Riechel, T. L. High Molecular Weight Plant Polyphenolics (Tannins) as Biological Antioxidants. Journal of agricultural and food chemistry 1998, 46 (5), 1887–1892. DOI: 10.1021/jf970975b.

*Indicates microbiome significance