Services

Panels (<20 compounds)

Platform Targets and Features Sample Type
acrylamide UHPLC-QqQ MS/MS acrylamide with stable isotope internal standard food
anthocyanin degradants UHPLC-QqQ MS/MS phenolic acids, e.g. protocatechuic acid (PCA), microbiome metabolites food, blood
anthocyanins UHPLC-QqQ MS/MS and UV-Vis glycosides of cyanidin, malvidin, petunidin, peonidin, pelargonidin, delphinidin food
anthocyanins UHPLC-QqQ MS/MS and UV-Vis glycosides of cyanidin, malvidin, petunidin, peonidin, pelargonidin, delphinidin, glucuronides blood, tissue, urine
apo-carotenoids UHPLC-QqQ MS/MS eccentric cleavage products of lycopene, beta-carotene blood
carotenoids C30 HPLC-UV-Vis beta-carotene, lutein, zeaxanthin, lycopene, cryptoxanthin, astaxanthin, neoxanthin, violaxanthin, phytoene, phytofluene food
carotenoids C30 HPLC-UV-Vis or SFC QTOF MS beta-carotene, lutein, zeaxanthin, lycopene, cryptoxanthin, astaxanthin, neoxanthin, violaxanthin, phytoene, phytofluene blood, tissue
cholesterol NP HPLC-QqQ MS/MS free cholesterol food or in vitro digest
e-cigarette vaping components UHPLC-QqQ MS/MS after derivatization propylene glycol, glycerol urine, blood, bronchoalveolar lavage fluid
ellagic acid metabolites UHPLC-QqQ MS/MS urolithin A, B, C, D, dimethyl ellagic acid, methyl UC, microbiome metabolites blood, urine
flavanone microbial degradants UHPLC-QqQ MS/MS phenolic acids, microbiome metabolites urine
flavanones UHPLC-QqQ MS/MS and UV-Vis glycosides of naringenin, hesperetin food
flavones UHPLC-QqQ MS/MS apigenin, luteolin, diosmetin, chrysoeriol blood, urine
flavones UHPLC-QqQ MS/MS and UV-Vis glycosides of apigenin, luteolin, diosmetin, chrysoeriol food
glucosinolates UHPLC-QqQ MS/MS glucoraphanin, glucoerucin, glucoiberin, sinigrin, glucobrassicin food
green tea phenolics UHPLC-QTOF MS/MS catechins, EGC, ECG, EGCG, phenyl valerolactones, microbiome metabolites, sulfated and glucuronidated conjugates foods, blood, mouse liver
isoflavones and metabolites UHPLC-QqQ MS/MS daidzein, genistein, glycitein; equol, dihydrodaidzein, ODMA, dihydrogenistein, 6-hydroxy ODMA blood, urine
isoflavones UHPLC-QqQ MS/MS and UV-Vis glucosides, malonyl glucosides, and acetyl glucosides of daidzein, genistein, and glycitein. Biochanin A, formononetin food
isothiocyanate (ITC) metabolites UHPLC-QqQ MS/MS or QTOF MS glutathionyl, cysteinylglycinyl, cysteinyl, N-acetyl cysteinyl blood, urine
linalool and metabolite UHPLC-QqQ MS/MS linalool, linalool glucuronide food, blood, urine
microcystin congeners – quantitative UHPLC-QqQ MS/MS MC-RR, MC-YR, MC-LR, MC-LA, MC-LW, MC-LF, MC-dspRR, MC-dspLR cell culture, environmental water samples, mouse liver, fish tissue, soil, vegetables
microcystins – total UHPLC-QqQ MS/MS MMPB method environmental water samples, mouse liver, fish tissue
microcystin-LR conjugates UHPLC-QqQ MS/MS MC-LR-glutathione, MC-LR-cysteine mouse liver
naringenin human metabolites UHPLC-QqQ MS/MS naringenin glucuronides, sulfates blood, urine
retinoids UHPLC-QqQ MS/MS retinoic acid, retinyl esters, retinol, retinal blood
soy saponins UHPLC-QqQ MS/MS type A, B, C, B DDMP food
vitamin D UHPLC-QqQ MS/MS and UV-Vis D2, D3 food
vitamin D status UHPLC-QqQ MS/MS 25OHD2, 25OHD3 blood

Panels  (>20 compounds)

Platform Examples Sample Type
black raspberry phytochemicals (~80) UHPLC-QTOF-MS and UV-Vis flavonoids, phenolic acids, ellagitannins, procyanidins, ellagic acid, ellagic acid derivatives food
burdock phenolics UHPLC-QTOF MS flavonoids plant leaves
microcystin congeners and water-borne toxins -survey UHPLC-QTOF MS/MS search accurate mass library of >100 known microcystins and toxins environmental water samples
soy phytochemicals UHPLC-QTOF MS phytosterols, saponins, isoflavones, lipids food
strawberry phytochemicals UHPLC-QTOF-MS and UV-Vis flavonoids, phenolic acids, ellagitannins, procyanidins, ellagic acid, ellagic acid derivatives food
tomato phytochemicals (>150) UHPLC-QTOF-MS and C30 HPLC UV-Vis glycoalkaloids, carotenoids, phenolic acids, flavonoids, lipids food

Lipidomics

Platform Features Sample Type
Targeted lipidomics (Lipidyzer®) Infusion/DMS/QqQ MS/MS 13 classes, >1100 lipid species blood, tissues, cell culture, milk, egg
Untargeted lipidomics SFC-QTOF MS, UHPLC-QTOF MS neutral, polar, sphingolipids, glycosylated

Untargeted Metabolomics

Steps UHPLC-QTOF MS
extraction
acquisition
feature finding
bioinformatics

Metabolic Phenotyping

Examples UHPLC-QqQ MS/MS
ellagic acid (urolithins)
flavanones
isoflavones
ITC conjugates

Data Analysis

Representations
PCA – principal component analysis
PLS-DA – penalized logistic regression and partial least squares discriminant analysis
VIP Plot – variable importance in projection plot
Pathways, Enrichment, Networks
See prices.