Welcome to the Mace Lab!


Our research is focused on translational tumor immunology – discovering new targets and pathways in the tumor microenvironment that can lead to improvements in patient responses to immune-based therapeutics.

The field of immunotherapy has exploded in the last several years with many successes and cures observed in patients, however few responses have been observed in pancreatic cancer.  Our laboratory is focused on further understanding the pancreatic tumor microenvironment and determining the mechanisms of resistance to immune-based therapeutics.  Many of these same immunsuppressive pathways observed in pancreatic cancer are also observed in other inflammatory diseases, such as chronic pancreatitis.  Our lab is also interested in uncovering immune-based targets and pathways in other pancreatic diseases.  Additionally, the laboratory is also investigating the use of dietary nutritional intervention to modulate inflammation in chronic diseases and cancer.

The ultimate goal of this work is to discover and identify novel immunological pathways that we can target in patients to hopefully improve responses in patients with cancer and inflammatory diseases.

Mace Laboratory News – Updated 07/01/2019

July 2019 – Dr. Mace was featured on Pelotonia’s Facebook live interview series to discuss his laboratory’s funded IDEA grant.  See below:



Join us for a Facebook live with Dr. Thomas Mace and learn about his Pelotonia research!

Posted by Pelotonia on Monday, July 1, 2019





May 2019 – Welcome Molly Torok to the laboratory as our new research assistant.  She is taking over research and laboratory managing duties from Fouad.



Mace Laboratory News – Updated 12/17/2018

December 2018 – Dr. Mace was awarded a Pelontonia Idea award from OSUCCC!  We are searching for a postdoctoral researcher to join the laboratory.  If interested in joining the lab, please email your CV and a cover letter to thomas.mace@osumc.edu.

August 2018 Pelotonia 2018 – The laboratory had another amazing Pelotonia bike ride this year!  Our lab for the first time was apart of the GHN division team, Guts in Gear, and raised over $5,000 in donations for 2018.  Thanks to all that donated and know that these funds will go directly to cancer research completed here at The James!