During the summers of 2018 and 2019 I had the opportunity to work as an Undergraduate Research Assistant at Indiana University School of Medicine in the Department of Radiation Oncology. The Primary Investigator of this lab is Joe Dynlacht, PhD. In his lab we studied the effects of chemotherapeutic agents that are not toxic to normal tissue at 37 °C when administered systemically, but can become toxic under local hyperthermia treatment. The agents I worked with were various metalloenediynes, including an iron sulfate enediyne and a platinated modified metalloenediyne. I performed experiments where I administered the agent to cells at different concentrations and tested the effects it had on those cells at 37 °C and 42.5 °C. The cells I worked with were MDA-231 (breast) and U1 (melanoma) human cancer cell lines. Through this experience I learned valuable skills including basic and sterile lab techniques, and working with mice in a laboratory setting. I even had the opportunity to co-author an article that was submitted to the Radiation Research journal in May 2019 called “Enhancement of cytotoxicity of enediyne compounds by hyperthermia: Effects of various metal co-factor complexes on tumor cells.”