As of July 2021, Dr. Kline is an Assistant Professor in the Department of Biostatistics and Data Science at Wake Forest School of Medicine.  This website is no longer maintained. Please visit


  • Elsheikh, B., Severyn, S., Zhao, S., Kline, D., Linsenmayer, M., Kelly, K., Tellez, M., Bartlett, A., Heintzman, S., Reynolds, J., Sterling, G., Weaver, T., Rajneesh, K., Kolb, S.J., & Arnold, W.D. (2021). Safety, tolerability, and effect of nusinersen in non-ambulatory adults with spinal muscular atrophy. Frontiers in Neurology, 12: 542. PMID: 33935949 PMCID: PMC8085528 DOI: 10.3389/fneur.2021.650532
  • Joseph, J.J., Pohlman, N.K., Zhao, S., Kline, D., Brock, G., Echouffo-Tcheugui, J.B., Sims, M., Effoe, V.S., Wu, W., Kalyani, R.R., Wand, G.S., Hsueh, W.A., Abdalla, M., Shimbo, D., & Golden, S.H. (2021). The association of serum aldosterone and plasma renin activity with ambulatory blood pressure: The Jackson Heart Study. Circulation. PMID: 33605160 DOI: 10.1161/CIRCULATIONAHA.120.050896 (in press)
  • Kline, D., Ji, Y., & Hepler, S. (2021). A multivariate spatio-temporal model of the opioid epidemic in Ohio: A factor model approach.  Health Services and Outcomes Research Methodology, 21: 42-53. DOI: 10.1007/s10742-020-00227-3
  • Kline, D., Pan, Y., & Hepler S. (2021). Spatio-temporal trends in opioid overdose deaths by race for counties in Ohio. Epidemiology, 32(2): 295-302. PMID: 33394810 DOI: 10.1097/EDE.0000000000001299
  • Kluwe, B., Zhao, S., Kline, D., Ortiz, R., Brock, G., Echouffo-Tcheugui, J.B., Sims, M., Kalyani, R.R., Golden, S.H., & Joseph, J.J. (2021). Adiposity measures and morning serum cortisol in African Americans: Jackson Heart Study. Obesity, 29(2): 418-427. PMID: 33491313 DOI: 10.1002/oby.23056
  • Kluwe, B., Ortiz, R., Odei, J.B., Zhao, S., Kline, D., Brock, G., Echouffo-Tcheugui, J.B., Lee, J., Lazarus, S., Seeman, T., Greenland, P., Needham, B., Carnethon, M.R., Golden, S.H., & Joseph, J. (2021). The Association of Cortisol Curve Features with Incident Diabetes among Whites and African Americans: The Coronary Artery Risk Development in Young Adults (CARDIA) Study. Psychoneuroendocrinology, 123, 105041. PMID: 33227536 DOI: 10.1016/j.psyneuen.2020.105041


  • Jamieson, N., Akande, M., Karsies, T.,  Smith, R.M., Kline, D., & Spencer, S.P. (2020). Respiratory Pathogen Detection in Pediatric Patients Intubated for Presumed Infection. Pediatric Emergency Care. DOI: 10.1097/PEC.0000000000002301  PMID: 33201137 (in press)
  • Hepler, S., Waller, L., & Kline, D. (2020). A Multivariate Spatio-Temporal Change Point Model of Opioid Overdose Deaths in Ohio. Annals of Applied Statistics. DOI: 10.1214/20-AOAS1415 (in press)
  • Schoenfeld, L., Janse, S., Kline, D., Aronow, M., Singh, A.D., Craven, C., Abdel-Rahman, M., & C. Cebulla, C. (2020). Estrogen receptor is expressed in uveal melanoma: A potential target for therapy. Ocular Oncology and Pathology. DOI: 10.1159/000512174 (in press)
  • Moberly, A., Vasil, K., Baxter, J., Klamer, B., Kline, D., & Ray, C. (2020). Comprehensive auditory rehabilitation in adults receiving cochlear implants: a pilot study. Laryngoscope Investigative Otolaryngology, 5, 911-918. PMID: 33134539 PMCID: PMC7585234 DOI: 10.1002/lio2.442
  • Linakis, S. W., Lloyd, J. K., Kline, D., Holmes, J. F., Stanley, R. M., & Leonard, J. C. (2020). Field triage of children with abdominal trauma. Trauma. DOI: 10.1177/1460408620933524
  • Meyer, A.P., Roggenbuck, J., Lorusso, S., Kissel, J., Smith, R.M., Kline, D., & Arnold, W.D. (2020). Genotype-phenotype correlations and characterization of medication use in inherited myotonic disorders. Frontiers in Neurology, 11, 593. PMID: 32670189 DOI: 10.3389/fneur.2020.00593
  • Kline, D. & Hepler S. (2020). Estimating the burden of the opioid epidemic for adults and adolescents in Ohio counties. Biometrics. PMID: 32413155 DOI: 10.1111/biom.13295 (in press)
  • Pena Dias, J., Joseph, J.J., Kluwe, B., Zhao, S., Shardell, M., Seeman, T., Needham, B.L., Wand, G.S., Kline, D.,  Brock, G., Castro-Diehl, C., & Golden, S.H. (2020). The longitudinal association of changes in diurnal cortisol features with fasting glucose: MESA. Psychoneuroendocrinology, 119, 104698. PMID: 32674946 DOI: 10.1016/j.psyneuen.2020.104698
  • Battisti, K.A., Cohen, D.M., Bourgeois, T., Kline, D., Zhao, S., & Iyer, M.S. (2020). A paucity of code status documentation despite increasing complex chronic disease in pediatrics. Journal of Palliative Medicine, 23(11), 1452-1459. PMID: 32213109 DOI: 10.1089/jpm.2019.0630
  • Karamians, R., Proffitt, R., Kline D., & Gauthier, L. (2020). Effectiveness of virtual reality- and gaming-based interventions for upper extremity rehabilitation post-stroke: A meta-analysis. Archives of Physical Medicine and Rehabilitation, 101(5), 885-896. PMID: 31821799 DOI: 10.1016/j.apmr.2019.10.195


  • Young, N.A., Brown, M.P., Peng, J., Kline, D., Reider, C., & Deogaonkar, M. (2019). Predicting extended hospital stay after deep brain stimulation surgery in Parkinson’s patients. Journal of Clinical Neuroscience, 69, 241-244. PMID: 31431404 DOI: 10.1016/j.jocn.2019.07.042
  • Saba, K., Hossieny, Z.S., Arnold, W.D., Elsheikh, B., Pallettas, M., Kline, D., & Stino, A.M. (2019). CSF protein level and short-term prognosis in Guillain Barre Syndrome. Journal of Clinical Neuromuscular Disease, 21(2), 118-119. PMID: 31743257 DOI: 10.1097/CND.0000000000000259
  • Gillespie, S., Anderson, C., Zhao, S., Tan, Y., Kline, D., Brock, G., Odei, J., O’Brien, E., Sims, M., Lazarus, S., Hood, D., Williams, K.P., & Joseph, J. (2019). Allostatic Load in the Association of Depressive Symptoms with Incident Coronary Heart Disease: The Jackson Heart Study.  Psychoneuroendocrinology, 109, 104369.  PMID: 31307010 DOI: 10.1016/j.psyneuen.2019.06.020
  • Liu, A., Kline, D., Brock, G., & Bonsu, B. (2019). Multistate model of the patient flow process in the pediatric emergency department. PLoS One, 14(7), 1-16. PMID: 31291345  DOI: 10.1371/journal.pone.0219514
  • Kesireddy, V., Tan, Y., Kluwe, B., Kline, D., Brock, G., Odei, J., Effoe, V.S., Echouffo Tchedugui, J.B., Kalyani, R.R., Sims, M., Taylor, H.A., Mongraw-Chaffin, M., Akhabue, E., & Joseph, J.J. (2019). The Association of Life’s Simple 7 with Aldosterone among African Americans in the Jackson Heart Study. Nutrients, 11, 955. PMID: 31035479 DOI: 10.3390/nu11050955
  • Suarez-Kelly, L.P., Yu, L., Kline, D., Schneider, E.B., Agnese, D.M., & Carson, W.E. (2019). Increased breast cancer risk in women with neurofibromatosis type 1: A meta-analysis and systematic review of the literature. Hereditary Cancer in Clinical Practice, 17(12), 1-13. PMID: 30962859 PMCID: PMC6434896 DOI: 10.1186/s13053-019-0110-z
  • La Count, S., Zhao, S., Kline, D., Lovett, M.E., O’Brien, N.F., Hall, M.W., & Sribnick, E.A. (2019). Factors associated with poor outcome in pediatric near-hanging injuries. The Journal of Emergency Medicine, 57(1), 21-28. PMID: 31031070 DOI: 10.1016/j.jemermed.2019.03.013
  •  Kloos, A.D., Kegelmeyer, D.A., Ambrogi, K., Kline, D., McCormack-Mager, M., Schroeder, B., & Kostyk, S. (2019). The Step Test Evaluation of Performance on Stairs (STEPS): validation and reliability in a neurological disorder. PLoS ONE, 14(3), 1-12. PMID: 30897107 PMCID: PMC6428278 DOI: 10.1371/journal.pone.0213698
  • Kline, D., Hepler, S., Bonny, A., & McKnight, E. (2019). A joint spatial model of opioid associated deaths and treatment admissions in Ohio.  Annals of Epidemiology, 33, 19-23. PMID: 30948153 PMCID: PMC6502680 DOI: 10.1016/j.annepidem.2019.02.004
  • Hepler, S., Bonny, A., McKnight, E., & Kline, D. (2019). A latent spatial factor approach for synthesizing opioid associated deaths and treatment admissions in Ohio counties. Epidemiology, 30(3), 365-370. PMID: 30882402 DOI: 10.1097/EDE.0000000000000978
  • Wang, H., Hecht, S., Kline, D., & Leber, A.L. (2019). Staphylococcus aureus and methicillin resistance detection directly from pediatric samples using pcr assays with differential cycle threshold values for corroboration of methicillin resistance. Journal of Microbiological Methods, 159, 167-173. PMID: 30826439 DOI: 10.1016/j.mimet.2019.01.009
  • Bressler, C., Letson, M., Kline, D., McCarthy, T., Davis, J., & Leonard, J. (2019). Characteristics of neighborhoods where emergency medical services encounter children at risk for maltreatment. Prehospital Emergency Care, 23(5),672-682. PMID: 30703337 DOI: 10.1080/10903127.2019.1573940
  • Echouffo-Tcheugui, J., Zhao, S., Brock, G., Kline, D., & Joseph, J. (2019). Visit-to-visit glycemic variability and risks of cardiovascular events and all-cause mortality: The ALLHAT study. Diabetes Care, 42(3), 468-493. PMID: 30659073 DOI: 10.2337/dc18-1430
  • Yackey, K., Stukus, K., Cohen, D., Kline, D., Zhao, S., & Stanley, R. (2019). Off-label medication prescribing patterns in pediatrics: An update. Hospital Pediatrics, 9(3), 186-193PMID: 30745323 DOI: 10.1542/hpeds.2018-0168
  • Caterino, J., Kline, D., Leininger, R., Southerland, L., Carpenter, C., Baugh, C., Pallin, D., Hunold, K., & Stevenson, K. (2019). Nonspecific symptoms lack diagnostic accuracy for infection in older emergency department patients. Journal of the American Geriatrics Society, 67, 484-492. PMID: 30467825 DOI: 10.1111/jgs.15679
  • LoRusso, S., Kline, D., Bartlett, A., Freimer, M., Rich, M., Kissel, J.T., & Arnold, W.D. (2019).  Open label trial of ranolazine for the treatment of paramyotonia congenita.  Muscle and Nerve, 59(2), 240–243. PMID: 30390395  DOI: 10.1002/mus.26372
  • Wier, C.G., Crum, A.E., Reynolds, A.B., Iyer, C.C., Chugh, D., Palettas, M.S., Heilman, P.L., Kline, D., Arnold, W.D., & Kolb, S.J. (2019). Muscle dysfunction precedes loss of motor unit connectivity in SOD1 (G93A) mice. Muscle and Nerve, 59(2), 254–262. PMID: 30370671 DOI: 10.1002/mus.26365
  • Stino, A.M., Atway, S., Anthony, M., Kline, D., & Kissel, J.T. (2019). Foot measures in patients with pes cavus with and without Charcot-Marie-Tooth disease: a pilot study. Muscle and Nerve, 59(1), 122-125. PMID: 30039580 DOI: 10.1002/mus.26309
  • Grisanti, K., Martorano, L., Redmond, M., Scherzer, R., Strothman, K., Malthaner, L., Davis, J., Zhao, S., Kline, D., & Leonard, J. (2019).  Emergency call characteristics and EMS dispatcher protocol adherence for possible anaphylaxis. Prehospital Emergency Care, 23 (5), 691-699. PMID: 30526221 DOI: 10.1080/10903127.2018.1557305


  • Mundy-Bosse, B.L., Denlinger, N., McLaughlin, E., Chakravarti, N., Huang, S., Chen, L., Mao, H.C., Kline, D., Youssef, Y., Kohnken, R., Young, K., Lee, D., Lozankski, G., Freud, A.G., Porcu, P., William, B., Caligiuri, M.A., & Mishra, A. (2018). Highly cytotoxic natural killer cells are associated with poor prognosis in patients with cutaneous t-cell lymphoma. Blood Advances, 15(2), 1818-1827. PMID: 30054309 PMCID: PMC6093742 DOI: 10.1182/bloodadvances.2018020388
  • Kelly, K.M., Borstad, A.L., Kline, D., & Gauthier, L.V. (2018). Improved quality of life following constraint-induced movement therapy is associated with gains in arm use, but not motor improvement.  Topics in Stroke Rehabilitation, 25(7), 467-474. PMID: 30246613 PMCID: PMC6359892 DOI: 10.1080/10749357.2018.1481605
  • Prior, D.E., Nurre, E., Roller, S.L., Kline, D., Panara, R., Stino, A.M., Davis, J.A., Freimer, M.L., & Arnold, W.D. (2018). Infections and the relationship to treatment in neuromuscular autoimmunity. Muscle and Nerve, 57(6), 927-931. PMID:29211921 PMCID: PMC5951723 DOI: 10.1002/mus.26032


  • Vaughn, J.L., Kline, D., Denlinger, N.M., Andritsos, L., Exline, M.C., & Walker, A.R. (2017).  Predictive performance of early warning scores in acute leukemia patients receiving induction chemotherapy. Leukemia & Lymphoma, 59(6), 1498-1500. PMID: 28901797 DOI: 10.1080/10428194.2017.1376744
  • Arnold, W.D., Kline, D., Sanderson, A., Bartlett, A., Novak, K.R., Rich, M.M., & Kissel, J.T. (2017). Open label trial of ranolazine for treatment of myotonia congenita. Neurology, 89(7), 710-713. PMID: 28710329 PMCID: PMC5562961 DOI: 10.1212/WNL.0000000000004229
  • Caterino, J.M., Leininger, R., Kline, D.M., Southerland, L.T., Khaliqdina, S., Baugh, C.W., Pallin, D.J., & Stevenson, K.B. (2017). Accuracy of current diagnostic criteria for acute bacterial infection in older emergency department patients. Journal of the American Geriatrics Society, 65(8), 1802-1809. PMID:28440855 PMCID: PMC5555798 DOI: 10.1111/jgs.14912.
  • Kline, D., Andridge, R., & Kaizar, E. (2017). Comparing multiple imputation methods for systematically missing subject-level data. Research Synthesis Methods, 8(2), 136-148. PMID: 26679326 DOI: 10.1002/jrsm.1192
  • Kline, D., Kaizar, E., Minich, N., Stancin, T., Taylor, H.G., Wade, S., & Yeates, K. (2017). Meta-analysis for studying psychological and social effects of pediatric traumatic brain  injury: existing studies and methods. DOI: 10.13140/RG.2.2.26712.60165
  • McKnight, E., Bonny, A.E., Lange, H.L., Kline, D., Abdel-Rasoul, M., Gay, J., & Matson, S.C. (2017). Statewide opioid prescriptions and the prevalence of adolescent opioid misuse in Ohio. American Journal of Drug and Alcohol Abuse 43(3), 299-305. PMID:27646841 PMCID:PMC5357590 DOI: 10.1080/00952990.2016.1216999
  • Makki, N., Kline, D.M., Kanmanthareddy, A., Mathelier, H., Shreenivas, S., Lilly, S.M. (2017). Procedure utilization, latency and mortality: Weekend versus Weekday admission for Myocardial Infarction. Journal of Cardiology and Cardiovascular Medicine, 2, 020-025. DOI: 10.29328/journal.jccm.1001008


  • Wang, H., Schwaderer, A. L., Kline, J., Spencer, J. D., Kline, D., & Hains, D. S. (2013). Contribution of structural domains to the activity of ribonuclease 7 against uropathogenic bacteria. Antimicrobial Agents and Chemotherapy, 57(2) 766-74. PMID: 23183439 PMCID: PMC3553692 DOI: 10.1128/AAC.01378-12


  • Carpenter, A., Paulus, A., Robinson, M., Bates, C., Robinson, M.L., Hains, D., Kline, D., & McHugh, K. (2012). 3-dimensional morphometric analysis of murine bladder development and dysmorphogenesis. Developmental Dynamics, 241(3), 522-533. PMID: 22275180 PMCID: PMC3288201 DOI: 10.1002/dvdy.23744


  • Seibert, S., King, T., Kline, D., Mende, C., & Craig, T. (2011). Reliability of skin test results when read at different time points. Allergy and Asthma Proceedings: The Official Journal Of Regional and State Allergy Societies, 32(3), 203-205. PMID: 21703100 DOI: 10.2500/aap.2011.32.3436