Research

As of July 2021, Dr. Kline is an Assistant Professor in the Department of Biostatistics and Data Science at Wake Forest School of Medicine.  This website is no longer maintained. Please visit https://sites.google.com/view/dkline. 

2021

  • Elsheikh, B., Severyn, S., Zhao, S., Kline, D., Linsenmayer, M., Kelly, K., Tellez, M., Bartlett, A., Heintzman, S., Reynolds, J., Sterling, G., Weaver, T., Rajneesh, K., Kolb, S.J., & Arnold, W.D. (2021). Safety, tolerability, and effect of nusinersen in non-ambulatory adults with spinal muscular atrophy. Frontiers in Neurology, 12: 542. PMID: 33935949 PMCID: PMC8085528 DOI: 10.3389/fneur.2021.650532
  • Joseph, J.J., Pohlman, N.K., Zhao, S., Kline, D., Brock, G., Echouffo-Tcheugui, J.B., Sims, M., Effoe, V.S., Wu, W., Kalyani, R.R., Wand, G.S., Hsueh, W.A., Abdalla, M., Shimbo, D., & Golden, S.H. (2021). The association of serum aldosterone and plasma renin activity with ambulatory blood pressure: The Jackson Heart Study. Circulation. PMID: 33605160 DOI: 10.1161/CIRCULATIONAHA.120.050896 (in press)
  • Kline, D., Ji, Y., & Hepler, S. (2021). A multivariate spatio-temporal model of the opioid epidemic in Ohio: A factor model approach.  Health Services and Outcomes Research Methodology, 21: 42-53. DOI: 10.1007/s10742-020-00227-3
  • Kline, D., Pan, Y., & Hepler S. (2021). Spatio-temporal trends in opioid overdose deaths by race for counties in Ohio. Epidemiology, 32(2): 295-302. PMID: 33394810 DOI: 10.1097/EDE.0000000000001299
  • Kluwe, B., Zhao, S., Kline, D., Ortiz, R., Brock, G., Echouffo-Tcheugui, J.B., Sims, M., Kalyani, R.R., Golden, S.H., & Joseph, J.J. (2021). Adiposity measures and morning serum cortisol in African Americans: Jackson Heart Study. Obesity, 29(2): 418-427. PMID: 33491313 DOI: 10.1002/oby.23056
  • Kluwe, B., Ortiz, R., Odei, J.B., Zhao, S., Kline, D., Brock, G., Echouffo-Tcheugui, J.B., Lee, J., Lazarus, S., Seeman, T., Greenland, P., Needham, B., Carnethon, M.R., Golden, S.H., & Joseph, J. (2021). The Association of Cortisol Curve Features with Incident Diabetes among Whites and African Americans: The Coronary Artery Risk Development in Young Adults (CARDIA) Study. Psychoneuroendocrinology, 123, 105041. PMID: 33227536 DOI: 10.1016/j.psyneuen.2020.105041

2020

  • Jamieson, N., Akande, M., Karsies, T.,  Smith, R.M., Kline, D., & Spencer, S.P. (2020). Respiratory Pathogen Detection in Pediatric Patients Intubated for Presumed Infection. Pediatric Emergency Care. DOI: 10.1097/PEC.0000000000002301  PMID: 33201137 (in press)
  • Hepler, S., Waller, L., & Kline, D. (2020). A Multivariate Spatio-Temporal Change Point Model of Opioid Overdose Deaths in Ohio. Annals of Applied Statistics. DOI: 10.1214/20-AOAS1415 (in press)
  • Schoenfeld, L., Janse, S., Kline, D., Aronow, M., Singh, A.D., Craven, C., Abdel-Rahman, M., & C. Cebulla, C. (2020). Estrogen receptor is expressed in uveal melanoma: A potential target for therapy. Ocular Oncology and Pathology. DOI: 10.1159/000512174 (in press)
  • Moberly, A., Vasil, K., Baxter, J., Klamer, B., Kline, D., & Ray, C. (2020). Comprehensive auditory rehabilitation in adults receiving cochlear implants: a pilot study. Laryngoscope Investigative Otolaryngology, 5, 911-918. PMID: 33134539 PMCID: PMC7585234 DOI: 10.1002/lio2.442
  • Linakis, S. W., Lloyd, J. K., Kline, D., Holmes, J. F., Stanley, R. M., & Leonard, J. C. (2020). Field triage of children with abdominal trauma. Trauma. DOI: 10.1177/1460408620933524
  • Meyer, A.P., Roggenbuck, J., Lorusso, S., Kissel, J., Smith, R.M., Kline, D., & Arnold, W.D. (2020). Genotype-phenotype correlations and characterization of medication use in inherited myotonic disorders. Frontiers in Neurology, 11, 593. PMID: 32670189 DOI: 10.3389/fneur.2020.00593
  • Kline, D. & Hepler S. (2020). Estimating the burden of the opioid epidemic for adults and adolescents in Ohio counties. Biometrics. PMID: 32413155 DOI: 10.1111/biom.13295 (in press)
  • Pena Dias, J., Joseph, J.J., Kluwe, B., Zhao, S., Shardell, M., Seeman, T., Needham, B.L., Wand, G.S., Kline, D.,  Brock, G., Castro-Diehl, C., & Golden, S.H. (2020). The longitudinal association of changes in diurnal cortisol features with fasting glucose: MESA. Psychoneuroendocrinology, 119, 104698. PMID: 32674946 DOI: 10.1016/j.psyneuen.2020.104698
  • Battisti, K.A., Cohen, D.M., Bourgeois, T., Kline, D., Zhao, S., & Iyer, M.S. (2020). A paucity of code status documentation despite increasing complex chronic disease in pediatrics. Journal of Palliative Medicine, 23(11), 1452-1459. PMID: 32213109 DOI: 10.1089/jpm.2019.0630
  • Karamians, R., Proffitt, R., Kline D., & Gauthier, L. (2020). Effectiveness of virtual reality- and gaming-based interventions for upper extremity rehabilitation post-stroke: A meta-analysis. Archives of Physical Medicine and Rehabilitation, 101(5), 885-896. PMID: 31821799 DOI: 10.1016/j.apmr.2019.10.195

2019

  • Young, N.A., Brown, M.P., Peng, J., Kline, D., Reider, C., & Deogaonkar, M. (2019). Predicting extended hospital stay after deep brain stimulation surgery in Parkinson’s patients. Journal of Clinical Neuroscience, 69, 241-244. PMID: 31431404 DOI: 10.1016/j.jocn.2019.07.042
  • Saba, K., Hossieny, Z.S., Arnold, W.D., Elsheikh, B., Pallettas, M., Kline, D., & Stino, A.M. (2019). CSF protein level and short-term prognosis in Guillain Barre Syndrome. Journal of Clinical Neuromuscular Disease, 21(2), 118-119. PMID: 31743257 DOI: 10.1097/CND.0000000000000259
  • Gillespie, S., Anderson, C., Zhao, S., Tan, Y., Kline, D., Brock, G., Odei, J., O’Brien, E., Sims, M., Lazarus, S., Hood, D., Williams, K.P., & Joseph, J. (2019). Allostatic Load in the Association of Depressive Symptoms with Incident Coronary Heart Disease: The Jackson Heart Study.  Psychoneuroendocrinology, 109, 104369.  PMID: 31307010 DOI: 10.1016/j.psyneuen.2019.06.020
  • Liu, A., Kline, D., Brock, G., & Bonsu, B. (2019). Multistate model of the patient flow process in the pediatric emergency department. PLoS One, 14(7), 1-16. PMID: 31291345  DOI: 10.1371/journal.pone.0219514
  • Kesireddy, V., Tan, Y., Kluwe, B., Kline, D., Brock, G., Odei, J., Effoe, V.S., Echouffo Tchedugui, J.B., Kalyani, R.R., Sims, M., Taylor, H.A., Mongraw-Chaffin, M., Akhabue, E., & Joseph, J.J. (2019). The Association of Life’s Simple 7 with Aldosterone among African Americans in the Jackson Heart Study. Nutrients, 11, 955. PMID: 31035479 DOI: 10.3390/nu11050955
  • Suarez-Kelly, L.P., Yu, L., Kline, D., Schneider, E.B., Agnese, D.M., & Carson, W.E. (2019). Increased breast cancer risk in women with neurofibromatosis type 1: A meta-analysis and systematic review of the literature. Hereditary Cancer in Clinical Practice, 17(12), 1-13. PMID: 30962859 PMCID: PMC6434896 DOI: 10.1186/s13053-019-0110-z
  • La Count, S., Zhao, S., Kline, D., Lovett, M.E., O’Brien, N.F., Hall, M.W., & Sribnick, E.A. (2019). Factors associated with poor outcome in pediatric near-hanging injuries. The Journal of Emergency Medicine, 57(1), 21-28. PMID: 31031070 DOI: 10.1016/j.jemermed.2019.03.013
  •  Kloos, A.D., Kegelmeyer, D.A., Ambrogi, K., Kline, D., McCormack-Mager, M., Schroeder, B., & Kostyk, S. (2019). The Step Test Evaluation of Performance on Stairs (STEPS): validation and reliability in a neurological disorder. PLoS ONE, 14(3), 1-12. PMID: 30897107 PMCID: PMC6428278 DOI: 10.1371/journal.pone.0213698
  • Kline, D., Hepler, S., Bonny, A., & McKnight, E. (2019). A joint spatial model of opioid associated deaths and treatment admissions in Ohio.  Annals of Epidemiology, 33, 19-23. PMID: 30948153 PMCID: PMC6502680 DOI: 10.1016/j.annepidem.2019.02.004
  • Hepler, S., Bonny, A., McKnight, E., & Kline, D. (2019). A latent spatial factor approach for synthesizing opioid associated deaths and treatment admissions in Ohio counties. Epidemiology, 30(3), 365-370. PMID: 30882402 DOI: 10.1097/EDE.0000000000000978
  • Wang, H., Hecht, S., Kline, D., & Leber, A.L. (2019). Staphylococcus aureus and methicillin resistance detection directly from pediatric samples using pcr assays with differential cycle threshold values for corroboration of methicillin resistance. Journal of Microbiological Methods, 159, 167-173. PMID: 30826439 DOI: 10.1016/j.mimet.2019.01.009
  • Bressler, C., Letson, M., Kline, D., McCarthy, T., Davis, J., & Leonard, J. (2019). Characteristics of neighborhoods where emergency medical services encounter children at risk for maltreatment. Prehospital Emergency Care, 23(5),672-682. PMID: 30703337 DOI: 10.1080/10903127.2019.1573940
  • Echouffo-Tcheugui, J., Zhao, S., Brock, G., Kline, D., & Joseph, J. (2019). Visit-to-visit glycemic variability and risks of cardiovascular events and all-cause mortality: The ALLHAT study. Diabetes Care, 42(3), 468-493. PMID: 30659073 DOI: 10.2337/dc18-1430
  • Yackey, K., Stukus, K., Cohen, D., Kline, D., Zhao, S., & Stanley, R. (2019). Off-label medication prescribing patterns in pediatrics: An update. Hospital Pediatrics, 9(3), 186-193. PMID: 30745323 DOI: 10.1542/hpeds.2018-0168
  • Caterino, J., Kline, D., Leininger, R., Southerland, L., Carpenter, C., Baugh, C., Pallin, D., Hunold, K., & Stevenson, K. (2019). Nonspecific symptoms lack diagnostic accuracy for infection in older emergency department patients. Journal of the American Geriatrics Society, 67, 484-492. PMID: 30467825 DOI: 10.1111/jgs.15679
  • LoRusso, S., Kline, D., Bartlett, A., Freimer, M., Rich, M., Kissel, J.T., & Arnold, W.D. (2019).  Open label trial of ranolazine for the treatment of paramyotonia congenita.  Muscle and Nerve, 59(2), 240–243. PMID: 30390395  DOI: 10.1002/mus.26372
  • Wier, C.G., Crum, A.E., Reynolds, A.B., Iyer, C.C., Chugh, D., Palettas, M.S., Heilman, P.L., Kline, D., Arnold, W.D., & Kolb, S.J. (2019). Muscle dysfunction precedes loss of motor unit connectivity in SOD1 (G93A) mice. Muscle and Nerve, 59(2), 254–262. PMID: 30370671 DOI: 10.1002/mus.26365
  • Stino, A.M., Atway, S., Anthony, M., Kline, D., & Kissel, J.T. (2019). Foot measures in patients with pes cavus with and without Charcot-Marie-Tooth disease: a pilot study. Muscle and Nerve, 59(1), 122-125. PMID: 30039580 DOI: 10.1002/mus.26309
  • Grisanti, K., Martorano, L., Redmond, M., Scherzer, R., Strothman, K., Malthaner, L., Davis, J., Zhao, S., Kline, D., & Leonard, J. (2019).  Emergency call characteristics and EMS dispatcher protocol adherence for possible anaphylaxis. Prehospital Emergency Care, 23 (5), 691-699. PMID: 30526221 DOI: 10.1080/10903127.2018.1557305

2018

  • Mundy-Bosse, B.L., Denlinger, N., McLaughlin, E., Chakravarti, N., Huang, S., Chen, L., Mao, H.C., Kline, D., Youssef, Y., Kohnken, R., Young, K., Lee, D., Lozankski, G., Freud, A.G., Porcu, P., William, B., Caligiuri, M.A., & Mishra, A. (2018). Highly cytotoxic natural killer cells are associated with poor prognosis in patients with cutaneous t-cell lymphoma. Blood Advances, 15(2), 1818-1827. PMID: 30054309 PMCID: PMC6093742 DOI: 10.1182/bloodadvances.2018020388
  • Kelly, K.M., Borstad, A.L., Kline, D., & Gauthier, L.V. (2018). Improved quality of life following constraint-induced movement therapy is associated with gains in arm use, but not motor improvement.  Topics in Stroke Rehabilitation, 25(7), 467-474. PMID: 30246613 PMCID: PMC6359892 DOI: 10.1080/10749357.2018.1481605
  • Prior, D.E., Nurre, E., Roller, S.L., Kline, D., Panara, R., Stino, A.M., Davis, J.A., Freimer, M.L., & Arnold, W.D. (2018). Infections and the relationship to treatment in neuromuscular autoimmunity. Muscle and Nerve, 57(6), 927-931. PMID:29211921 PMCID: PMC5951723 DOI: 10.1002/mus.26032

2017

  • Vaughn, J.L., Kline, D., Denlinger, N.M., Andritsos, L., Exline, M.C., & Walker, A.R. (2017).  Predictive performance of early warning scores in acute leukemia patients receiving induction chemotherapy. Leukemia & Lymphoma, 59(6), 1498-1500. PMID: 28901797 DOI: 10.1080/10428194.2017.1376744
  • Arnold, W.D., Kline, D., Sanderson, A., Bartlett, A., Novak, K.R., Rich, M.M., & Kissel, J.T. (2017). Open label trial of ranolazine for treatment of myotonia congenita. Neurology, 89(7), 710-713. PMID: 28710329 PMCID: PMC5562961 DOI: 10.1212/WNL.0000000000004229
  • Caterino, J.M., Leininger, R., Kline, D.M., Southerland, L.T., Khaliqdina, S., Baugh, C.W., Pallin, D.J., & Stevenson, K.B. (2017). Accuracy of current diagnostic criteria for acute bacterial infection in older emergency department patients. Journal of the American Geriatrics Society, 65(8), 1802-1809. PMID:28440855 PMCID: PMC5555798 DOI: 10.1111/jgs.14912.
  • Kline, D., Andridge, R., & Kaizar, E. (2017). Comparing multiple imputation methods for systematically missing subject-level data. Research Synthesis Methods, 8(2), 136-148. PMID: 26679326 DOI: 10.1002/jrsm.1192
  • Kline, D., Kaizar, E., Minich, N., Stancin, T., Taylor, H.G., Wade, S., & Yeates, K. (2017). Meta-analysis for studying psychological and social effects of pediatric traumatic brain  injury: existing studies and methods. DOI: 10.13140/RG.2.2.26712.60165
  • McKnight, E., Bonny, A.E., Lange, H.L., Kline, D., Abdel-Rasoul, M., Gay, J., & Matson, S.C. (2017). Statewide opioid prescriptions and the prevalence of adolescent opioid misuse in Ohio. American Journal of Drug and Alcohol Abuse 43(3), 299-305. PMID:27646841 PMCID:PMC5357590 DOI: 10.1080/00952990.2016.1216999
  • Makki, N., Kline, D.M., Kanmanthareddy, A., Mathelier, H., Shreenivas, S., Lilly, S.M. (2017). Procedure utilization, latency and mortality: Weekend versus Weekday admission for Myocardial Infarction. Journal of Cardiology and Cardiovascular Medicine, 2, 020-025. DOI: 10.29328/journal.jccm.1001008

2013

  • Wang, H., Schwaderer, A. L., Kline, J., Spencer, J. D., Kline, D., & Hains, D. S. (2013). Contribution of structural domains to the activity of ribonuclease 7 against uropathogenic bacteria. Antimicrobial Agents and Chemotherapy, 57(2) 766-74. PMID: 23183439 PMCID: PMC3553692 DOI: 10.1128/AAC.01378-12

2012

  • Carpenter, A., Paulus, A., Robinson, M., Bates, C., Robinson, M.L., Hains, D., Kline, D., & McHugh, K. (2012). 3-dimensional morphometric analysis of murine bladder development and dysmorphogenesis. Developmental Dynamics, 241(3), 522-533. PMID: 22275180 PMCID: PMC3288201 DOI: 10.1002/dvdy.23744

2011

  • Seibert, S., King, T., Kline, D., Mende, C., & Craig, T. (2011). Reliability of skin test results when read at different time points. Allergy and Asthma Proceedings: The Official Journal Of Regional and State Allergy Societies, 32(3), 203-205. PMID: 21703100 DOI: 10.2500/aap.2011.32.3436

2010