Publications

Discoidin Domain Receptors and Collagen

Loss of Discoidin Domain Receptor 1 Predisposes Mice to Periodontal Breakdown.

Chavez, Michael & Kolli, Tamara & Tan, Michelle & Zachariadou, Christina & Wang, Carolyn & Embree, M.C. & Lira dos Santos, Elis & Nociti, Francisco & Wang, Y. & Tatakis, Dimitris & Agarwal, Gunjan & Foster, Brian. (2019).  Journal of Dental Research. 98. 1521– 1531. 10.1177/0022034519881136.

https://doi.org/10.1177/0022034519881136

 

Modulation of biomimetic mineralization of collagen by soluble ectodomain of discoidin domain receptor 2.

Farzadi, Arghavan & Renner, Theodore & Calomeni, Edward & Presley, Kayla & Karn, Nicole & Lannutti, John & Dasi, Lakshmi & Agarwal, Gunjan. (2019). Materials Science and Engineering C. 104. 109905. 10.1016/j.msec.2019.109905.

https://doi.org/10.1016/j.msec.2019.109905

 

Discoidin domain receptors: Micro insights into macro assemblies.

Agarwal, Gunjan & Smith, Adam & Jones, Blain. (2019). Biochimica et Biophysica Acta (BBA) – Molecular Cell Research. 1866. 10.1016/j.bbamcr.2019.06.010.

https://doi.org/10.1016/j.bbamcr.2019.06.010

 

Clustering, Spatial Distribution and Phosphorylation of Discoidin Domain Receptors 1 and 2 in Response to Soluble Collagen Type I.

Yeung, David & Shanker, Nirvan & Sohail, Anjum & Weiss, Brent & Wang, Carolyn & Wellmerling, Jack & Das, Subhadip & Ganju, Ramesh & Miller, Jeanette & Herr, Andrew & Fridman, Rafael & Agarwal, Gunjan. (2018). Journal of Molecular Biology. 431. 10.1016/j.jmb.2018.11.015.

https://doi.org/10.1016/j.jmb.2018.11.015

 

Collagen Fibril Ultrastructure in Mice Lacking Discoidin Domain Receptor 1.

Tonniges, Jeffrey & Albert, Benjamin & Calomeni, Edward & Roy, Shuvro & Lee, Joan & Mo, Xiaokui & Cole, Susan & Agarwal, Gunjan. (2016). Microscopy and Microanalysis. 22. 599-611. 10.1017/S1431927616000787.

https://doi.org/10.1017/S1431927616000787

 

Discoidin Domain Receptors: Unique Receptor Tyrosine Kinases in Collagen-mediated Signaling.

Fu, Hsueh-Liang & Valiathan, Rajeshwari & Arkwright, Richard & Sohail, Anjum & Mihai, Cosmin & Kumarasiri, Malika & Mahasenan, Kiran & Mobashery, Shahriar & Huang, Paul & Agarwal, Gunjan & Fridman, Rafael. (2013). The Journal of biological chemistry. 288. 7430-7. 10.1074/jbc.R112.444158.

https://www.jbc.org/content/288/11/7430.full

 

Oligomerization of DDR1 ECD affects receptor–ligand binding.

Yeung, David & Chmielewski, David & Mihai, Cosmin & Agarwal, Gunjan. (2013). Journal of structural biology. 183. 10.1016/j.jsb.2013.06.010.

https://doi.org/10.1016/j.jsb.2013.06.010

 

Inhibition of Collagen Fibrillogenesis by Cells Expressing Soluble Extracellular Domains of DDR1 and DDR2.

Flynn, Lisa & Blissett, Angela & Calomeni, Edward & Agarwal, Gunjan. (2010). Journal of Molecular Biology. 395. 533-543. 10.1016/j.jmb.2009.10.073.

https://doi.org/10.1016/j.jmb.2009.10.073

 

Regulation Of Collagen Fibrillogenesis By Cell Surface Expression Of Kinase Dead DDR2.

Blissett, Angela & Garbellini, Derek & Calomeni, Edward & Mihai, Cosmin & Elton, Terry & Agarwal, Gunjan. (2008). Journal of molecular biology. 385. 902-11. 10.1016/j.jmb.2008.10.060.

https://doi.org/10.1016/j.jmb.2008.10.060

 

Mapping of DDR1 Distribution and Oligomerization on the Cell Surface by FRET Microscopy.

Mihai, Cosmin & Chotani, Maqsood & Elton, Terry & Agarwal, Gunjan. (2008). Journal of molecular biology. 385. 432-45. 10.1016/j.jmb.2008.10.067.

https://doi.org/10.1016/j.jmb.2008.10.067

 

Interaction of Discoidin Domain Receptor 1 with Collagen type 1.

Agarwal, Gunjan & Mihai, Cosmin & Iscru, Daniel. (2007). Journal of molecular biology. 367. 443-55. 10.1016/j.jmb.2006.12.073.

https://doi.org/10.1016/j.jmb.2006.12.073

 

Discoidin Domain Receptor 2 Inhibits Fibrillogenesis of Collagen Type 1.

Mihai, Cosmin & Iscru, Daniel & Druhan, Lawrence & Elton, Terry & Agarwal, Gunjan. (2006). Journal of molecular biology. 361. 864-76. 10.1016/j.jmb.2006.06.067.

https://doi.org/10.1016/j.jmb.2006.06.067

 

Binding of Discoidin Domain Receptor 2 to Collagen I: An Atomic Force Microscopy Investigation.

Agarwal, Gunjan & Kovac, Lubomir & Radziejewski, Czeslaw & Samuelsson, Steven. (2002). Biochemistry. 41. 11091-8. 10.1021/bi020087w.

https://pubs.acs.org/doi/abs/10.1021/bi020087w

 

Collagen Remodeling in Health and Disease

The Myosin and RhoGAP MYO9B Influences Osteocyte Dendrite Growth and Responses to Mechanical Stimuli

Beth S Lee, Cynthia Murray, Jie Liu, Minji Kim, Min Sik Hwang, Tina Yueh, Myrna Mansour, Sana Qamar, Gunjan Agarwal, Do-Gyoon Kim. (2023). Frontiers in Bioengineering and Biotechnology, 11, 1243303

doi: 10.3389/fbioe.2023.1243303

 

Loss of Jagged1 in mature endothelial cells causes vascular dysfunction with alterations in smooth muscle phenotypes

Randa M Breikaa, Kimberly Denman, Yukie Ueyama, Patricia E McCallinhart, Aiman Q Khan, Gunjan Agarwal, Aaron J Trask, Vidu Garg, Brenda Lilly. (2022). Vascular Pharmacology, Jul 2;145:107087.

doi: 10.1016/j.vph.2022.107087.

 

Structurally abnormal collagen fibrils in abdominal aortic aneurysm resist platelet adhesion

 

Mathematical model of atherosclerotic aneurysm

Guoyi Ke, Chetan Hans, Gunjan Agarwal, Kristine Orion, Michael Go and Wenrui Hao. (2021). Mathematical Biosciences and Engineering,  Jan 27;18(2):1465-1484.

Mathematical model of atherosclerotic aneurysm (aimspress.com)

 

Effect of penetration enhancer with novel corneal cross-linking using recombinant human decoron in porcine eyes.

Christopher S Pappa, B Audrey Nguyen, Ashraf M Mahmoud, Gunjan Agarwal and Cynthia J Roberts. (2021). Experimental Eye Research, May;206:108542

https://doi.org/10.1016/j.exer.2021.108542

 

Characterization of the human intervertebral disc cartilage endplate at the molecular, cell and tissue level.

Lakstins, Katherine & Arnold, Lauren & Gunsch, Gilian & Flanigan, David & Khan, Safdar & Gadde, Nikhit & Jones, Blain & Agarwal, Gunjan & Purmessur, Devina. (2020). Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 10.1002/jor.24854.

https://doi.org/10.1002/jor.24854

 

DAPT, a potent Notch inhibitor regresses actively growing abdominal aortic aneurysm via divergent pathways.

Hans, Chetan & Sharma, Neekun & Dev, Rishabh & Blain, Jones & Tonniges, Jeff & Agarwal, Gunjan. (2020). Clinical Science. 134. 10.1042/CS20200456.

https://doi.org/10.1042/CS20200456

 

Collagen fibril abnormalities in human and mice abdominal aortic aneurysm.

Jones, Blain & Tonniges, Jeffrey & Debski, Anna & Albert, Benjamin & Yeung, David & Gadde, Nikhit & Mahajan, Advitiya & Sharma, Neekun & Calomeni, Edward & Go, Michael & Hans, Chetan & Agarwal, Gunjan. (2020). Acta Biomaterialia. 110. 10.1016/j.actbio.2020.04.022.

https://doi.org/10.1016/j.actbio.2020.04.022

 

Serum versus Imaging Biomarkers in Friedreich Ataxia to Indicate Left Ventricular Remodeling and Outcomes.

Mehta, Nishaki & Chacko, Paul & Jin, James & Tran, Tam & Prior, Thomas & He, Xin & Agarwal, Gunjan & Raman, Subha. (2016). Texas Heart Institute Journal. 43. 305-310. 10.14503/THIJ-14-4198.

https://doi.org/10.14503/THIJ-14-4198

 

Ex Vivo Transepithelial Collagen Cross-linking in Porcine and Human Corneas Using Human Decorin Core Protein.

Metzler, Kimberly & Roberts, Cynthia & Mahmoud, Ashraf & Agarwal, Gunjan & Liu, Jun. (2016). Journal of Refractive Surgery. 32. 410-417. 10.3928/1081597X-20160428-08.

https://doi.org/10.3928/1081597X-20160428-08

 

Biomechanical Properties and Correlation With Collagen Solubility Profile in the Posterior Sclera of Canine Eyes With an ADAMTS10 Mutation.

Palko, Joel & Iwabe, Simone & Pan, Xueliang & Agarwal, Gunjan & Komaromy, Andras & Liu, Jun. (2013). Investigative ophthalmology & visual science. 54. 10.1167/iovs.12-10621.

https://doi.org/10.1167/iovs.12-10621

 

Biomechanics and Mechanobiology

Dissociation of pulse wave velocity and aortic wall stiffness in diabetic db/db mice: The influence of blood pressure

Patricia E McCallinhart, Yong Ung Lee, Avione Lee, Mircea Anghelescu, Jeffrey R Tonniges, Ed Calomeni, Gunjan Agarwal, Joy Lincoln, Aaron J Trask (2023). Frontiers in Physiology 14(476).

 

Independent control of matrix adhesiveness and stiffness within a 3D self-assembling peptide hydrogel.

Hogrebe, Nathaniel & Reinhardt, James & Tram, Nguyen & Debski, Anna & Agarwal, Gunjan & Reilly, Matthew & Gooch, Keith. (2018). Acta Biomaterialia. 70. 10.1016/j.actbio.2018.01.031.

https://doi.org/10.1016/j.actbio.2018.01.031

 

Vascular Mechanics in Decellularized Aortas and Coronary Resistance Microvessels in Type 2 Diabetic db/db Mice.

Anghelescu, Mircea & Tonniges, Jeffrey & Calomeni, Ed & Shamhart, Patricia & Agarwal, Gunjan & Gooch, Keith & Trask, Aaron. (2015). Annals of biomedical engineering. 43. 10.1007/s10439-015-1333-4.

https://link.springer.com/article/10.1007/s10439-015-1333-4

 

A self-assembling peptide matrix used to control stiffness and binding site density supports the formation of microvascular networks in 3D.

Stevenson, M & Piristine, Hande & Hogrebe, N.J. & Nocera, Tanya & Boehm, M.W. & Reen, R.K. & Koelling, K.W. & Agarwal, Gunjan & Sarang-Sieminski, Alisha & Gooch, Keith. (2013). Acta biomaterialia. 9. 10.1016/j.actbio.2013.04.002.

https://doi.org/10.1016/j.actbio.2013.04.002

 

The influence of discoidin domain receptor 2 on the persistence length of collagen type I fibers.

Sivakumar, Lalitha & Agarwal, Gunjan. (2010). Biomaterials. 31. 4802-8. 10.1016/j.biomaterials.2010.02.070.

https://doi.org/10.1016/j.biomaterials.2010.02.070

 

Changes in surface topologies of chondrocytes subjected to mechanical forces: An AFM analysis.

Iscru, Daniel & Anghelina, Mirela & Agarwal, Sudha & Agarwal, Gunjan. (2008). Journal of structural biology. 162. 397-403. 10.1016/j.jsb.2008.02.005.

https://doi.org/10.1016/j.jsb.2008.02.005

 

Sickle Hemoglobin Fibers: Mechanisms of Depolymerization.

Agarwal, Gunjan & Wang, Jiang & Kwong, Suzanna & Cohen, Scott & Ferrone, Frank & Josephs, Robert & Briehl, Robin. (2002). Journal of molecular biology. 322. 395-412. 10.1016/S0022-2836(02)00770-2.

https://doi.org/10.1016/S0022-2836(02)00770-2

 

Micromechanics of isolated sickle cell hemoglobin fibers: Bending moduli and persistence lengths.

Wang, Jiang & Turner, Matthew & Agarwal, Gunjan & Kwong, Suzanna & Josephs, Robert & Ferrone, Frank & Briehl, Robin. (2002). Journal of molecular biology. 315. 601-12. 10.1006/jmbi.2001.5130.

https://doi.org/10.1006/jmbi.2001.5130

 

Magnetic Force Microscopy

Artifacts in magnetic force microscopy of histological sections

Kevin J Walsh, Owen Shiflett, Stavan Shah, Theodore Renner, Nicholas Soulas, Douglas Scharre, Dana McTigue, Gunjan Agarwal (2022). Journal of Magnetism and Magnetic Materials.

https://doi.org/10.1016/j.jmmm.2022.170116

 

Effects of fixatives on histo-magnetic evaluation of iron in rodent spleen.

Walsh, Kevin J. & Shah, Stavan & Wei, Ping & Oberdick, Samuel D. & McTigue, Dana and Agarwal, Gunjan. (2021). Journal of Magnetism and Magnetic Materials.

https://doi.org/10.1016/j.jmmm.2020.167531

 

Indirect Magnetic Force Microscopy.

Sifford, Joshua & Walsh, Kevin & Tong, Sheng & Bao, Gang & Agarwal, Gunjan. (2019). Nanoscale Advances. 1. 10.1039/C9NA00193J.

https://pubs.rsc.org/en/content/articlehtml/2019/na/c9na00193j

 

Sub-cellular In-situ Characterization of Ferritin(iron) in a Rodent Model of Spinal Cord Injury.

Blissett, Angela & Deng, B. & Wei, P. & Walsh, Kevin & Ollander, B. & Sifford, J. & Sauerbeck, A. & McComb, D. & McTigue, D. & Agarwal, Gunjan. (2018). Scientific Reports. 8. 10.1038/s41598-018-21744-9.

https://www.nature.com/articles/s41598-018-21744-9

 

Magnetic mapping of iron in rodent spleen.

Blissett, Angela & Ollander, Brooke & Penn, Brittany & Mctigue, Dana & Agarwal, Gunjan. (2016). Nanomedicine: Nanotechnology, Biology and Medicine. 13. 10.1016/j.nano.2016.11.011.

https://doi.org/10.1016/j.nano.2016.11.011

 

Distinguishing ferritin from apoferritin using magnetic force microscopy.

Nocera, Tanya & Zeng, Yuzhi & Agarwal, Gunjan. (2014). Nanotechnology. 25. 461001. 10.1088/0957-4484/25/46/461001.

https://iopscience.iop.org/article/10.1088/0957-4484/25/46/461001/meta

 

Magnetic anisotropy considerations in magnetic force microscopy studies of single superparamagnetic nanoparticles.

Nocera, Tanya & Chen, Jun & Murray, Christopher & Agarwal, Gunjan. (2012). Nanotechnology. 23. 495704. 10.1088/0957-4484/23/49/495704.

https://iopscience.iop.org/article/10.1088/0957-4484/23/49/495704/meta

 

Magnetic Force Microscopy of an Oxygen‐Sensing Spin‐Probe.

Savla, Mayur & Pandian, Ramasamy & Kuppusamy, Periannan & Agarwal, Gunjan. (2010). Israel Journal of Chemistry. 48. 33 – 38. 10.1560/IJC.48.1.33.

https://onlinelibrary.wiley.com/doi/abs/10.1560/IJC.48.1.33

 

Magnetic Force Microscopy of Superparamagnetic Nanoparticles.

Schreiber, Sharon & Savla, Mayur & Pelekhov, Denis & Iscru, Daniel & Marginean Selcu, Camelia & Hammel, P & Agarwal, Gunjan. (2008). Small (Weinheim an der Bergstrasse, Germany). 4. 270-8. 10.1002/smll.200700116.

https://onlinelibrary.wiley.com/doi/abs/10.1002/smll.200700116

 

Nanotechnology

Lifting and Sorting of Charged Au Nanoparticles by Electrostatic Forces in Atomic Force Microscopy.

Jiapeng, xu & Kwak, Kwang & Lee, Ly & Agarwal, Gunjan. (2010). Small (Weinheim an der Bergstrasse, Germany). 6. 2105-8. 10.1002/smll.201000924.

https://doi.org/10.1002/smll.201000924

 

Ceramic Nanoparticle Assemblies with Tailored Shapes and Tailored Chemistries via Biosculpting and Shape-Preserving Inorganic Conversion.

Dickerson, M.B. & Naik, R.R. & Sarosi, P.M. & Agarwal, Gunjan & Stone, Morley & Sandhage, Kenneth. (2005). Journal of nanoscience and nanotechnology. 5. 63-7. 10.1166/jnn.2005.008.

https://doi.org/10.1166/jnn.2005.008

 

Bio-inspired approaches and biologically derived materials for coatings.

Naik, Rajesh & Brott, Lawrence & Rodriguez, Francisco & Agarwal, Gunjan & Kirkpatrick, Sean & Stone, Morley. (2003). Progress in Organic Coatings. 47. 249-255. 10.1016/S0300-9440(03)00141-3.

https://doi.org/10.1016/S0300-9440(03)00141-3

 

Dip-Pen Nanolithography in Tapping Mode.

Agarwal, Gunjan & Sowards, Laura & Naik, Rajesh & Stone, Morley. (2003). Journal of the American Chemical Society. 125. 580-3. 10.1021/ja020471g.

https://doi.org/10.1021/ja020471g

 

Immobilization of Histidine-Tagged Proteins on Nickel by Electrochemical Dip Pen Nanolithography.

Agarwal, Gunjan & Naik, Rajesh & Stone, Morley. (2003). Journal of the American Chemical Society. 125. 7408-12. 10.1021/ja029856p.

https://doi.org/10.1021/ja029856p

 

Biomimetic synthesis and patterning of silver nanoparticles.

Naik, Rajesh & Stringer, Sarah & Agarwal, Gunjan & Jones, Sharon & Stone, Morley. (2002). Nature materials. 1. 169-72. 10.1038/nmat758.

https://www.nature.com/articles/nmat758

 

Book Chapters

DDRs and Collagen Fibrillogenesis.

Agarwal, Gunjan. (2016). Discoidin Domain Receptors in Health and Disease (pp. 23-56).  10.1007/978-1-4939-6383-6_2.

 

Atomic Force Microscopy.

Agarwal, Gunjan & Nocera, Tanya. (2012). The Nanobiotechnology Handbook.

 

Characterization of magnetic nanoparticles using magnetic force microscopy.

Agarwal, Gunjan. (2011). Nanotechnologies for the Life Sciences.

 

Introduction to Biological Light Microscopy.

Agarwal, Gunjan. (2008). Microscopic Image Analysis for Life Science Applications.