MN dendrites  MN with SV2COVER SUGGESTION 320130822_ZebraFish-27

(for a complete list visit PubMed)

Banasavadi-Siddegowda YK, Welker AM, An M, Yang X, Zhou W, Shi G, Imitola J, Li C, Hsu S, Wang J, Phelps M, Zhang J, Beattie CE, Baiocchi R, Kaur B. (2017) PRMT5 as a druggable target for glioblastoma therapy. Neuro Oncology. [Epub ahead of print]

Hao LT, Duy PQ, An M, Talbot J, Iyer CC, Wolman M, Beattie CE. (2017) HuD and the Survival Motor Neuron protein interact in motoneurons are are essential for motoneuron development, function, and mRNA regulation. Journal of Neuroscience. [Epub ahead of print]

Canella A, Welker AM, Yoo JY, Xu J, Abas FS, Kesanakurti D, Nagarajan P, Beattie CE, Sulman EP, Liu J, Gumin J, Lang FF, Gurcan MN, Kaur B, Sampath D, Puduvalli VK. (2017) Efficacy of Onalespib, a long-acting second-generation HSP90 inhibitor, as a single agent and in combination with Temozolomide against malignant gliomas.  Clinical Cancer Research 23(20):6215-6226. PMID:

Welker AM, Jaros BD, An M, Beattie CE (2017) Changes in tumor cell heterogeneity after chemotherapy treatment in a xenograph model of glioblastoma. Neuroscience 25;356:35-43.

Duy PQ, Berberoglu MA, Beattie CE, Hall CW (2017) Cellular responses to recurrent pentylenetretrazole-induced seizures in the adult zebrafish brain. Neuroscience 4;349:118-127.

Ferraiuolo L, Meyer K, Sherwood TW, Vick J, Likhite S, Frakes A, Miranda CJ, Braun L, Heath PR, Pineda R, Beattie CE, Shaw PJ, Askwith CC, McTigue D, Kaspar BK. (2016) Oligodendrocytes contribute to motor neuron death in ALS via SOD1-dependent mechanism. Proceedings of the National Academy of Science U S A. 18;113(42):E6496-E6505.

Welker AM, Jaros BD, Puduvalli VK, Imitola J, Kaur B, Beattie CE. (2016) Standardized orthotopic xenografts in zebrafish reveal glioma cell-line-specific characteristics and tumor cell heterogeneity. Disease Models and Mechanisms. 9(2):199-210.

Li H, Custer SK, Gilson T, Hao le T, Beattie CE, Androphy EJ. (2015) a-COP binding to the survival motor neuron protein SMN is required for neuronal process outgrowth. Human Molecular Genetics 24(25):7295-307.

Hao le T, Duy, P. Q, Jontes, J.D., and Beattie, C. E. (2015) Motoneuron development influences dorsal root ganglia survival and Schwann cell development in a vertebrate model of spinal muscular atrophy. Human Molecular Genetics 24: 346-360.

Lyon, A. N., Pineda, R. H., Hao, le T., Kudryashova, E., Kudryashov, D. S., and Beattie, C. E. (2014) Calcium binding is essential for plastin 3 function in Smn-deficient motoneurons. Human Molecular Genetics 23(8):1990-2004.

Gassman, A., Hao, le T., Bhoite, L., Bradford, C. L, Chien, C.-B., Beattie C. E., and Manfredi, J. P. (2013)  Small molecule suppressors of Drosophila Kinesin deficiency rescue motor axon development in a zebrafish model of spinal muscular atrophy.PLoS One. 8(9):e74325.

Hao, le T., Duy, P. Q., Jontes, J. D., Wolman, M., Granato, M., and Beattie, C. E. (2013) Temporal requirement for SMN in motoneuron development. Human Molecular Genetics 22:2612-2625.

McGown, A., McDearmid, J. R., Panagiotaki ,N., Tong, H., Al Mashhadi, S., Redhead, N., Lyon, A. N., Beattie, C. E., Shaw, P. J., and Ramesh,  T.M. (2013) Early interneuron dysfunction in ALS: Insights from a mutant sod1 zebrafish model.  Annals of Neurolology 73: 246-258.

Lotti, F., Imlach, W. L., Saieva, L., Beck, E. S., Hao, L. T.,  Li, D. K., Jiao, W. Mentis, G. Z. Beattie, C.E., McCabe, B. D.and Pellizzoni, L. (2012) A SMN-dependent U12 splicing event essential for motor circuit  function. Cell, 151: 440-454.

Hao le T, Wolman M, Granato M, Beattie C. E. (2012) Survival motor neuron affects plastin 3 levels leading to motor defects. Journal of Neuroscience 32: 5074-5084.

Akten, B., Kye, M.J., Hao, le T., Wertz, M. H., Singh, S., Nie, D., Huang, J., Merianda, T. T., Twiss, J. L., Beattie, C. E., Steen, J. A., and Sahin, M. (2011) Interaction of survival of motor neuron (SMN) and HuD proteins with mRNA cpg15 rescues motor neuron axonal defects. Proc Natl Acad Sci U S A. 21;108:10337-10342.

Hao le T. Burghes, A. H. M., and Beattie, C. E.  (2011) Generation and Characterization of a genetic zebrafish model of SMA carrying the human SMN2 gene. Molecular Neurodegeneration 6: 24.

Ramesh T., Lyon, A. N., Pineda, R. H., Wang, C., Janssen, P. M. L., Canan, B. D., Burghes, A. H. M. and Beattie, C. E. (2010) A genetic model of amyotrophic lateral sclerosis in zebrafish displays phenotypic hallmarks of motoneuron disease. Disease Models and Mechanisms 3: 652-662.

Burghes, A. H. and Beattie, C. E. (2009) Spinal muscular atrophy: why do low levels of survival motor neuron protein make motor neurons sick? Nature Reviews Neuroscience 10:  597-609.

Boon, K. L., Xiao, S., McWhorter, M. L., Donn, T., Wolf-Saxon, E., Bohnsack, M. T., Moens, C. B., Beattie, C. E. (2009)Zebrafish survival motor neuron Mutants Exhibit Presynaptic Neuromuscular  Junction Defects. Human Molecular Genetics 18: 3615-3625.

Oprea, G. E., Kröber, S., McWhorter, M. L., Rossoll, W., Müller, S. Krawczak, M., Bassell, G. J., Beattie, C. E. and Wirth, B. (2008) Plastin 3 is a Protective Modifier of Autosomal Recessive Spinal Muscular Atrophy. Science 320: 524-527.

McWhorter, M. L., Boon, K., Horan, E. S., Burghes, A. H. M., and Beattie, C. E.  (2008) The SMN complex protein Gemin2 is not involved in zebrafish motor axon outgrowth. Developmental  Neurobiology 68: 182-94.

Carrel, T. L., McWhorter, M. L., Workman, E. ZhangH., WolstencroftE. C., LorsonC., Bassell, G., BurghesA. H. M., and Beattie, C. E.(2006) SMN function in motor axons is independent of functions required for snRNP biogenesis. Journal of Neuroscience 26: 11014-11022. Highlighted in This Week in the Journal.

McWhorter, M. L., Monani, U.R., Burghes, A. H. M. and Beattie, C. E. (2003) Knock down of the Survival Motoneuron protein (Smn) in zebrafish causes defects in motor axon outgrowth and pathfinding. The Journal of Cell Biology 162: 919-931.