Viruses Special Issue: Retroviral Integration is accepting submissions

Kristine Yoder and Amit Sharma are Guest Editors of a Special Issue of Viruses focused on Retroviral Integration.

Integration is a defining feature of the retroviral life cycle. Major consequences of integration are the ability of the virus to remain latent for extended time and the inability to cure patients infected with HIV-1 or HTLV-1. Advances in the purification and assembly of integrases from multiple retroviral genera have revealed these proteins form a variety of multimeric complexes ranging from the prototype foamy virus tetramer to the Maedi visna virus dodecamer. Integrase-interacting host factors that tether viral integration complexes to chromatin and determine integration site selectivity have been identified for multiple retroviruses. Novel anti-retroviral therapeutics target integrase catalytic function, multimerization, and interaction with host factors. Understanding the fundamentals of integration processes and structure/function of integrases are critical for development of anti-retroviral therapies as well as safer gene therapy vectors. 

In this Special Issue, we invite research papers and review articles focused on all aspects of retroviral integration. Relevant topics include, but are not limited to: structure/function studies of integrase, integrase host factors, trafficking of integration complexes, integration site selection, anti-retroviral inhibitors targeting integration (not limited to integrase inhibitors), latency, and development of retroviral vectors.

The deadline for manuscript submissions to this special issue is May 31, 2022.

https://www.mdpi.com/journal/viruses/special_issues/retroviral_integration_2022

NIAID CRISPR Workshop

Kristine Yoder, PhD, is presenting at the NIAID Workshop on Applications of CRISPR-Cas and Similar Techniques for Established and Emerging Infectious Diseases. The title of her presentation is “CRISPR Genome Editing Applied tothe Pathogenic Retrovirus HTLV-1.” She is also moderating the Applications session. A highly engaging and informative workshop!

CRISPRAgenda

Welcome new undergraduates!

We have always enjoyed having undergraduates as part of our team. We truly missed them during COVID-19 pandemic restrictions during the summer of 2020. Now we are excited to welcome 4 new undergraduates to our group starting this Spring and working with us through Summer, 2021:

Tasha Bruner, Class of 2022, majoring in Biomedical Engineering

Michael Kaplan, Class of 2023, majoring in Biomedical Engineering

Sasan (Sam) Esmailzadeh, Class of 2023, majoring in Physics

Rebecca Morton, Class of 2024, majoring in Microbiology, minoring in Epidemiology

Welcome undergraduates!

 

OSU CVM is hiring multiple virologists

The Ohio State University College of Veterinary Medicine invites applications for multiple research-intensive tenure-track faculty positions at the Assistant or Associate Professor level in emerging and re-emerging viruses that expand and build upon our programmatic strengths, expertise, assets and impact. Areas of interest include, but are not limited to virus-host interactions, animal models, ecology, immunology, genetics and evolution, structural biology, and zoonotic transmission. Successful candidates will join a highly interactive virology and infectious disease research community on campus that is an integral part of the university’s Infectious Disease Institute, including the Center for Retrovirus Research, Center of Microbiome Science, and a newly NIH-funded center, STOP-COVID. These positions are part of the university’s new initiatives on research for academic excellence. The College of Veterinary Medicine has a long and outstanding history of research excellence in Signature Programs, including research focus areas in infectious diseases, comparative oncology, neuromusculoskeletal sciences, molecular virology, epidemiology, and vaccine development.

Viral Pathogens Faculty Search Position Description

Discovery Prep Journal Club

Kristine Yoder is the guest speaker today at the Discovery Prep journal club. The course is moderated by Kay Huebner, PhD. Discovery Prep (Postbaccalaureate Research Education Program) is an NIH funded one year training program for students in biomedical sciences and serves as preparation for successful graduate program applications. Thank you to the students for an excellent discussion!

Welcome, Dr. Larue!

We are delighted that Ross Larue, Ph.D., has joined our team as a Research Assistant Professor. He has tremendous experience in the field of retroviral integration and is an instant asset to our group. Welcome, Ross!

CFF Gene Insertion Workshop

Kristine Yoder, PhD, is delighted to present her work at the Cystic Fibrosis Foundation Gene Insertion Workshop. Her presentation is “Retroviral integration/identifying DNA targets.” It was an exciting workshop and an honor to be invited.

Welcome, Tony Rabe!

Due to COVID-19 pandemic restrictions, we’ve been unable to have undergraduates work in the lab. Those restrictions are easing and we are excited to welcome our first undergraduate to the lab. Welcome Tony Rabe!