Selected Publications:

  1. Laing ED, Navaratnarajah CK, Cheliout Da Silva S, et al, Broder CC# and Xu K#. Structural and Functional Analyses Reveal Promiscuous and Species-Specific Use of Ephrin Receptors by Cedar Virus. (2019) Proc Natl Acad Sci U S A. Oct 8;116(41):20707-20715. (#corresponding author)
  2. Xu J*, Xu K*, Jung S, Conte A, Lieberman J, Muecksch F, Lorenzi JCC, Park S, Schmidt F, Wang Z, Huang Y, Luo Y, Nair M, Wang P, Schulz JE, Tessarollo L, Bylund T, Chuang GY, Olia AS, Stephens T, Teng IT, Tsybovsky Y, Zhou T, Munster V, Ho DD, Hatziioannou T, Bieniasz PD, Nussenzweig MC, Kwong PD, Casellas R. Nanobodies from camelid mice and llamas neutralize SARS-CoV-2 variants. (2021) Nature. Jun 7. PMID:34098567. (*Co-first author)
  3. Yiwei Chen*, Kai Xu*, Luca Piccoli, Mathilde Foglierini, Joshua Tan, Wenjie Jin, Jason Gorman, Yaroslav Tsybovsky, Baoshan Zhang, Boubacar Traore, Chiara Silacci-Fregni, Claudia Daubenberger, Peter D. Crompton, Roger Geiger, Federica Sallusto, Peter D. Kwong & Antonio Lanzavecchia Structural basis of malaria RIFIN binding by LILRB1-containing antibodies (2021)Nature Apr;592(7855):639-643. PMID: 33790470 (*Co-first author)
  4. Xu K*, Acharya P*, Kong R*, Cheng C*, et al, Mascola JR, Kwong PD. Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1. (2018) Nat Med. Jun;24(6):857-867. (*Co-first author)
  5. Kong R*, Duan H*, Sheng Z*, Xu K*, Acharya P*, Chen X*, Cheng C*, Dingens AS*, Gorman J*, Sastry M*, Shen CH*, Zhang B*, Zhou T*, et al, Kwong PD, Mascola JR. Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization. (2019) Cell. Jul 25; 178(3): 567-584. (*Co-first author)
  6. Kong R*, Xu K*, Zhou T*, et al, Kwong PD, Mascola JR. Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody. (2016) Science. May 13;352(6287):828-33. (*Co-first author)
  7. Xu K*, Wu Z*, Renier N*, Antipenko A, Tzvetkova-Robev D, Xu Y, Minchenko M, Nardi-Dei V, Rajashankar KR, Himanen J, Tessier-Lavigne M, Nikolov DB. Structures of netrin-1 bound to two receptors provide insight into its axon guidance mechanism. (2014) Science. 344(6189):1275-9.

Research Papers:

  1. Madan B, Zhang B, Xu K, Chao CW, O’Dell S, Wolfe JR, Chuang GY, Fahad AS, Geng H, Kong R, Louder MK, Nguyen TD, Rawi R, Schön A, Sheng Z, Nimrania R, Wang Y, Zhou T, Lin BC, Doria-Rose NA, Shapiro L, Kwong PD, DeKosky BJ. Mutational fitness landscapes reveal genetic and structural improvement pathways for a vaccine-elicited HIV-1 broadly neutralizing antibody. (2021) Proc Natl Acad Sci U S A. Mar 9;118(10): PMID: 33649208; PMCID: PMC7958426.
  2. Corrigan AR, Duan H, Cheng C, Gonelli CA, Ou L, Xu K, DeMouth ME, Geng H,Narpala S, O’Connell S, Zhang B, Zhou T, Basappa M, Boyington JC, Chen SJ,O’Dell S, Pegu A, Stephens T, Tsybovsky Y, van Schooten J, Todd JP, Wang S; VRCProduction Program, Doria-Rose NA, Foulds KE, Koup RA, McDermott AB, van Gils MJ, Kwong PD, Mascola JR. Fusion peptide priming reduces immune responses to HIV-1 envelope trimer base. (2021) Cell Rep. Apr 6;35(1):108937. PMID: 33826898; PMCID: PMC8070658.
  3. Cheng C*, Duan H*, Xu K*, Chuang GY, Corrigan AR, Geng H, O’Dell S, Ou L, Chambers M, Changela A, Chen X, Foulds KE, Sarfo EK, Jafari AJ, Hill KR, Kong R, Liu K, Todd JP, Tsybovsky Y, Verardi R, Wang S, Wang Y, Wu W, Zhou T; VRC Production Program, Arnold FJ, Doria-Rose NA, Koup RA, McDermott AB, Scorpio DG, Worobey M, Shapiro L, Mascola JR, Kwong PD. Immune Monitoring Reveals Fusion Peptide Priming to Imprint Cross-Clade HIV-Neutralizing Responses with a Characteristic Early B Cell Signature.(2020) Cell Rep. Aug 4 (*Co-first author)
  4. Shen C*, DeKosky BJ*, Guo Y*, Xu K*, et al, Mascola JR, Kwong PD. VRC34-Antibody Lineage Development Reveals How a Required Rare Mutation Shapes the Maturation of a Broad HIV-Neutralizing Lineage. (2020) Cell Host and Microbe. Apr 8 (*Co-first author)
  5. Chuang GY, Lai YT, Boyington JC, Cheng C, Geng H, Narpala S, Rawi R, Schmidt SD, Tsybovsky Y, Verardi R, Xu K, et al, Mascola JR, Kwong PD. Development of a 3Mut-Apex-Stabilized Envelope Trimer that Expands HIV-1 Neutralization Breadth When Used To Boost Fusion Peptide-Directed Vaccine-Elicited Responses. (2020) J Virol. Apr 15
  6. Ou L, Kong WP, Chuang GY, Ghosh M, Gulla K, O’Dell S, Varriale J, Barefoot N, Changela A, Chao CW, Cheng C, Druz A, Kong R, McKee K, Rawi R, Sarfo EK, Schön A, Shaddeau A, Tsybovsky Y, Verardi R, Wang S, Wanninger TG, Xu K, et al, Mascola JR, Kwong PD. Preclinical Development of a Fusion Peptide Conjugate as an HIV Vaccine Immunogen. (2020) Sci Rep. Feb 20
  7. Mogus AT, Liu L, Jia M, Ajayi DT, Xu K, Kong R, Huang J, Yu J, Kwong PD, Mascola JR, Ho DD, Tsuji M, Chackerian B. Virus-Like Particle Based Vaccines Elicit Neutralizing Antibodies against the HIV-1 Fusion Peptide. Vaccines 2020 Dec 15;8(4):765. PMID: 33333740; PMCID: PMC7765226.
  8. Cheng C*, Xu K*, et al, Mascola JR, Kwong PD. Consistent elicitation of cross-clade HIV-neutralizing responses achieved in guinea pigs after fusion peptide priming by repetitive envelope trimer boosting. (2019) PLoS One. Apr 17;14(4) (*Co-first author)
  9. Dingens AS, Acharya P, Haddox HK, Rawi R, Xu K, et al, Overbaugh J, Kwong PD, Bloom JD. Complete functional mapping of infection- and vaccine-elicited antibodies against the fusion peptide of HIV. (2018) PLoS Pathog. 14:e1007159.
  10. Stewart-Jones GBE*, Chuang GY*, Xu K*, Zhou T*, Acharya P*, Tsybovsky Y*, et al, Mascola JR, Lanzavecchia A, Kwong PD. Structure-based design of a quadrivalent fusion glycoprotein vaccine for human parainfluenza virus types 1-4. (2018) Proc Natl Acad Sci U S A. (2018) Nov 27;115(48):12265-12270. (*Co-first author)
  11. Saunders KO, Verkoczy LK, Jiang C, Zhang J, Parks R, Chen H, Housman M, Bouton-Verville H, Shen X, Trama AM, Scearce R, Sutherland L, Santra S, Newman A, Eaton A, Xu K, et al, Haynes BF. Vaccine Induction of Heterologous Tier 2 HIV-1 Neutralizing Antibodies in Animal Models. (2017) Cell Rep. Dec 26;21(13):3681-3690.
  12. Chuang GY*, Geng H*, Pancera M*, Xu K*, et al, Mascola JR, Kwong PD. Structure-Based Design of a Soluble Prefusion-Closed HIV-1 Env Trimer with Reduced CD4 Affinity and Improved Immunogenicity. (2017) J Virol. Apr 28;91(10). (*Co-first author)
  13. Zhou T, Doria-Rose NA, Cheng C, Stewart-Jones GBE, Chuang GY, Chambers M, Druz A, Geng H, McKee K, Kwon YD, O’Dell S, Sastry M, Schmidt SD, Xu K, et al, Mascola JR, Kwong PD. Quantification of the Impact of the HIV-1-Glycan Shield on Antibody Elicitation. (2017) Cell Rep. Apr 25;19(4):719-732.
  14. Xu K, Zhou T,Mascola, JR, Kwong, PD, et al. Development of a Soluble HIV-1 Env Trimer Immunogen Stabilized in the Pre-fusion Closed State from Strain CH505 Conference: Conference on HIV Research for Prevention (HIVR4P) Location: Chicago, IL (2016) AIDS RESEARCH AND HUMAN RETROVIRUSES Oct 17-20, 32(1):98-98
  15. Atapattu L, Saha N, Chheang C, Eissman MF, Xu K, et al, Nikolov DB, Lackmann M, Janes PW. An activated form of ADAM10 is tumor selective and regulates cancer stem-like cells and tumor growth. (2016) J Exp Med. Aug 22;213(9):1741-57.
  16. Xu K*, Chan YP*, Bradel-Tretheway B*, Akyol-Ataman Z*, Zhu Y*, Dutta S, Yan L, Feng Y, Wang LF, Skiniotis G, Lee B, Zhou ZH, Broder CC, Aguilar HC, Nikolov DB. Crystal Structure of the Pre-fusion Nipah Virus Fusion Glycoprotein Reveals a Novel Hexamer-of-Trimers Assembly. (2015) PLoS Pathog. Dec 8;11(12)
  17. Xu K, Olsen O, Tzvetkova-Robev D, Tessier-Lavigne M, Nikolov DB. The crystal structure of DR6 in complex with the amyloid precursor protein provides insight into death receptor activation. (2015) Genes Dev. 29(8):785-90
  18. Zhong L, Chen XF, Zhang ZL, Wang Z, Shi XZ, Xu K, Zhang YW, Xu H, Bu G. DAP12 Stabilizes the C-terminal Fragment of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) and Protects against LPS-induced Pro-inflammatory Response. (2015) J Biol Chem. Jun 19;290(25):15866-77.
  19. Xu K, Rockx B, Xie YH, DeBuysscher BL, Fusco DL, Zhu ZY, Chan YP, Xu Y, Luu T, Cer RZ, Feldmann H, Mokashi V, Dimitrov DS, Bishop-Lilly KA, Broder CC, Nikolov DB. Crystal structure of the Hendra virus attachment G glycoprotein bound to a potent cross-reactive neutralizing human monoclonal antibody. (2013) PLoS Pathog., 9(10):e1003684.
  20. Xu K*, Tzvetkova-Robev D*, Xu Y, Goldgur Y, Chan YP, Himanen JP, Nikolov DB. Insights into Eph receptor tyrosine kinase activation from crystal structures of the EphA4 ectodomain and its complex with ephrin-A5. (2013) Proc Natl Acad Sci U S A; 110(36):14634-9.
  21. Xu K, Xu Y, Rajashankar KR, Robev D, Nikolov DB. Crystal structures of Lgr4 and its complex with R-spondin1. (2013) Structure; 21(9):1683-9.
  22. Xu K, Chan YP, Rajashankar KR, Khetawat D, Yan L, Kolev MV, Broder CC, Nikolov DB. New insights into the Hendra virus attachment and entry process from structures of the virus G glycoprotein and its complex with Ephrin-B2. (2012) PLoS One; 7(11):e48742.
  23. Chan YP, Lu M, Dutta S, Yan L, Barr J, Flora M, Feng YR, Xu K, Nikolov DB, Wang LF, Skiniotis G, Broder CC. Biochemical, conformational, and immunogenic analysis of soluble trimeric forms of henipavirus fusion glycoproteins. (2012) J Virol.; 86(21):11457-71.
  24. Colgrave ML, Snelling HJ, Shiell BJ, Feng YR, Chan YP, Bossart KN, Xu K, Nikolov DB, Broder CC, Michalski WP. Site occupancy and glycan compositional analysis of two soluble recombinant forms of the attachment glycoprotein of Hendra virus. (2012) Glycobiology; 22(4):572-84.
  25. Singla N, Goldgur Y, Xu K, Paavilainen S, Nikolov DB, Himanen JP. Crystal structure of the ligand-binding domain of the promiscuous EphA4 receptor reveals two distinct conformations. (2010) Biochem Biophys Res Commun.; 399(4):555-9.
  26. Himanen JP, Yermekbayeva L, Janes PW, Walker JR, Xu K, Atapattu L, Rajashankar KR, Mensinga A, Lackmann M, Nikolov DB, Dhe-Paganon S. Architecture of Eph receptor clusters. (2010) Proc Natl Acad Sci U S A. 2010; 107(24):10860-5.
  27. Xu K, Rajashankar KR, Chan YP, Himanen JP, Broder CC, Nikolov DB. Host cell recognition by the henipaviruses: crystal structures of the Nipah G attachment glycoprotein and its complex with ephrin-B3. (2008) Proc Natl Acad Sci U S A; 105(29):9953-8.
  28. Hervé M, Xu K, Ng YS, Wardemann H, Albesiano E, Messmer BT, Chiorazzi N, Meffre E. Unmutated and mutated chronic lymphocytic leukemias derive from self-reactive B cell precursors despite expressing different antibody reactivity. (2005) J Clin Invest.; 115(6):1636-43.
  29. Hu Y, Chuang JZ, Xu K, McGraw TG, Sung CH. SARA, a FYVE domain protein, affects Rab5-mediated endocytosis. (2002) J Cell Sci.; 115(Pt 24):4755-63.1.