March 2024
JOURNAL ARTICLE ACCEPTED: D Johnson, N Doble and SS Choi, “Quantitative Analysis of the Vasculature and Cone Photoreceptors in Subjects with Diabetes without Diabetic Retinopathy” Accepted to Current Eye Research.
Danae’s PhD work examining OCT-A, AO-OCT-SLO imaging in prediabetic subjects.
Feb 2024
JOURNAL ARTICLE PUBLISHED: Lee, SS Choi, RK Meleppat, RJ Zawadzki, N Doble, “High-speed, phase contrast retinal and blood flow imaging using an adaptive optics partially confocal multi-line ophthalmoscope” Biomed. Opt. Express, 15(3), 1815-1830 (2024).
Details our 500 Hz line scanning ophthalmoscope using phase contrast imaging that provides excellent visualization of retinal blood flow.
Jan 2024
December 2024
JOURNAL ARTICLE PUBLISHED: N Doble, EM Wells-Gray, SS Choi. “Foveal Cone Loss in Tamoxifen Maculopathy” Medical Case Reports. 17(464) (2023).
Details observed foveal cone loss in a patient on tamoxifen treatment for breast cancer.
Sept 2023
LAB PERSONNEL: Dr. Swati Padhee joins the group as a postdoctoral fellow to further our work using artificial intelligence. Funded through our recent NIH P30 Core Grant
June 2023
JOURNAL ARTICLE ACCEPTED FOR PUBLICATION: N Doble, EM Wells-Gray, M Ohr, SS Choi, “High Resolution Imaging of the Outer Retina in Type 2 Acute Macular Neuroretinopathy” Retinal Cases and Brief Reports
May 2023
NEW LAB MEMBER: Erin Hudson joins the lab as an OD/MS student
NEW LAB MEMBER: David Stout joins the lab as an OD/MS student
April 2023
SEMINAR: Nathan recently gave a presentation entitled “Visualizing the Human Retina with Adaptive Optics Enabled Imaging Modalities” in the Department of Ophthalmology at Indiana University.
4 conference presentations at the Annual ARVO Meeting in New Orleans
N Doble, EM Wells-Gray, M Ohr, SS Choi, “Adaptive Optics OCT Imaging in Type 2 Acute Macular Neuroretinopathy”, Investigative Ophthalmology & Visual Science, New Orleans, May 2023.
S Lee, SS Choi, RK Meleppat, RJ Zawadzki, N Doble, “High-speed adaptive optics multi-detection mode ophthalmoscope using a digital micromirror device” Investigative Ophthalmology & Visual Science, New Orleans, May 2023.
SS Choi, E Ivey, S Araujo-Hernandez, N Doble, “In vivo imaging of cone photoreceptors from both central and periphery” Investigative Ophthalmology & Visual Science, New Orleans, May 2023.
RK Meleppat, E Pijewska, S Lee, D Valente Dos Santos, RS Jonnal, N Doble, RJ Zawadzki, “Progress on a full-field swept-source optical coherence tomography (FF-SS-OCT) system for mouse optoretinography (ORG)” Investigative Ophthalmology & Visual Science, New Orleans, May 2023.
January 2023
CONFERENCE: Four abstracts accepted to ARVO 2023. Nathan, Stacey, Soohyun and our collaborator at UC Davis, Ratheesh will all be presenting. See you in New Orleans, April 23-27th!
https://www.arvo.org/annual-meeting/registration2/registration/
CONFERENCE: Back from San Francisco after attending Photonics West – excellent conference. Soohyun and Ratheesh gave great presentations.
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December 2022
JOURNAL ARTICLE PUBLISHED: Lee, S. S. Choi, R. K. Meleppat, R. J. Zawadzki, N. Doble, “Programmable, high-speed, adaptive optics partially confocal ophthalmoscope using a digital micromirror device”, Opt. Lett. 48(3), 791-794 (2023).
Details the performance of a 250 Hz frame rate ophthalmoscope, much faster the single scanning spot approaches.
September 2022
JOURNAL ARTICLE PUBLISHED: Mengxi had his manuscript accepted.
M. Zhou, N Doble, SS Choi, T Jin, X. Xu, S. Parthasarathy, R Ramnath, “Using Deep Learning for Automated Identification of Cone and Rod Photoreceptors from Adaptive Optics Imaging of the Human Retina” Biomedical Optics Express. 13(10): 5082-5097 (2022). For the feature issue: ‘Adaptive Optics for Biomedical Applications’.
August 2022
JOURNAL ARTICLE PUBLISHED: Carol’s paper is finally published on our laser damage work! C Vitellas, N Doble, EM Wells-Gray, N Challa, F Davidorf, SS. Choi, “Cone Photoreceptor Integrity assessed with Adaptive Optics Imaging after Laser-Pointer-Induced Retinal Injury” Retinal Cases and Brief Reports. 16(5):586-592, (2022).
June 2022
GRANT: The National Eye Institute (NEI) awarded OSU a $3 Million Core grant to support vision science research at the University. Nathan is Director of Core C – Image Analysis and Data Science
Jan 2022
CONFERENCE PRESENTATION: RJ Zawadzki, D Valente, RK Meleppat, Vienola, SJ Karlen, P Zhang, RS. Jonnal, N Doble. “Full Field Swept Source Optical Coherence Tomography (FF-SS-OCT) system for in vivo evaluation of light evoked activation of photoreceptors (optoretinography) in mice” Proc. SPIE PC11941, Ophthalmic Technologies XXXII, March 7th, 2022.
October 2020
GRANT: Stacey awarded the 2020 Allergan Foundation Grant in glaucoma from the American Academy of Optometry (AAO).
https://www.aaopt.org/home/aaof/news-detail/2020/10/01/american-academy-of-optometry-foundation-is-pleased-to-announce-the-2020-2021allergan-foundation-research-grant-recipients
September 2020
News article from a recent journal publication from our lab highlighting the potential dangers of low power laser pointers to the human eye.
https://news.osu.edu/pet-laser-pointers-have-enough-power-to-blast-away-cells-in-the-back-of-the-eye/
August 2020
GRANT: Nathan awarded a $2.3 million R01 grant from the National Eye Institute to develop the next generation of OCT instrumentation for functional measurements on a single retinal neuron. The grant is a collaboration with the University of California Davis.
LAB PERSONNEL: Dr. Danae Johnson joins the lab as a PhD student.
July 2020
LAB PERSONNEL: Sadhvika Venkat joins the lab as an OD/MS student. Welcome!
June 2020
GRANT: Nathan along with collaborators from the Department of Engineering and Computer Science were awarded a one year grant from the OSU Translational Data Analytics Institute to apply artificial intelligence in the analysis of retinal images
PAPER: Carol’s paper accepted to Retinal Cases and Brief Reports.
Cone Photoreceptor Integrity assessed with Adaptive Optics Imaging after Laser-Pointer-Induced Retinal Injury
May 2020
LAB PERSONNEL: Dr. Daniel Mittelstaedt joins the group as a postdoctoral fellow to further the work imaging inner retinal structure.
January 2020
GRANT: Stacey and Nathan along with collaborators in the OSU Department of Neurology were awarded a one year grant to examine structural changes in the retina of retired National Football League (NFL) players suffering with chronic traumatic encephalopathy
December 2019
GRANT: Nathan awarded a two year grant from the Ann Ellis Fund of the Columbus Foundation to use adaptive optics to study changes in the inner nuclear layer of patients with glaucoma
September 2019
Congratulations to Emma on her travel grant from the American Academy of Optometry Foundation
August 2019
LAB PERSONNEL: Sophie Araujo-Hernandez joins the lab as an OD/MS student. Welcome!
May 2019
Congratulations to 1st year medical students Nayanika Challa and Carol Vitellas winners of Ohio State University Medical Center Student Research Summer Scholarships. Will be working with us over the summer!
Also welcome to OSU undergraduates Emily Demmert, Olivia Severyn, Erin Ivey. They will be helping on our AAO myopia project
LAB PERSONNEL: Christi Locke successfully defends her MS thesis entitled “In vivo cone photoreceptor imaging in adolescents as a measure of retinal stretch during refractive error development”. Up next, a one year residency at Cincinnati Children’s Hospital in pediatric optometry
CONFERENCE PRESENTATION: Off to Vancouver! Stacey and Elaine presenting at ARVO
Adaptive Optics OCT-Based Drusen Grading for Assessing Severity of Dry Age-Related Macular Degeneration
Volumetric Imaging of Retinal Ganglion Cells and Inner Retinal Microstructure using a Combined AO-OCT-SLO
March 2019
PATENT: N Doble, L Blanco, JL Codona, HG Morris. Rapid Measurement of Individual Cone Photoreceptor Pointing for Evaluation of Eye Health using Focus Diversity. US 10,231,618 B2
February 2019
CONFERENCE PRESENTATION: Elaine presents at Photonics West in San Francisco.
Photoreceptor identification and quantitative analysis for the detection of retinal disease using AO-OCT imaging
January 2019
GRANT: UnEYEted Grant to study the inner retina using AO-OCT. Collaboration with OSU Ophthalmology
December 2018
PAPER: Elaine’s paper published.
Structural Integrity of Individual Cone Photoreceptors after Short-Wavelength Subthreshold Micropulse Laser Therapy for Diabetic Macular Edema. Ophthalmic Surgical Lasers and Imaging
November 2018
PAPER: Some of the first images of individual neurons in the inner retina Inner. Nuclear Layer Changes in Primary Open Angle Glaucoma Revealed through Adaptive Optics Optical Coherence Tomography. Journal of Glaucoma
CONFERENCE PRESENTATION: Stacey presents at the American Academy of Optometry Annual Meeting in San Antonio.
Retinal Imaging with an Adaptive Optics-Optical Coherence Tomography- Scanning Laser Ophthalmoscope (AO-OCT-SLO) and Its Clinical Application
CONFERENCE PRESENTATION: Christi presents at the same meeting.
In vivo Cone Photoreceptor Imaging in Adolescents as a Measure of Retinal Stretch during Refractive Error Development
October 2018
NEW TEACHING COURSE: High Resolution Imaging of the Eye using Adaptive Optics
CONFERENCE PRESENTATION: Stacey presents at the American Academy of Ophthalmology Annual Meeting in Chicago
Retinal Imaging with an Adaptive Optics-Optical Coherence Tomography- Scanning Laser Ophthalmoscope (AO-OCT-SLO) and Its Clinical Application
May 2018
LAB PERSONNEL: Dr. Shaojie Men joins as a postdoctoral fellow from the University of Seattle. Welcome!
LAB PERSONNEL: Emma Thompson joins the lab as an OD/MS student – co-supervised with Dr. Ooi
April 2018
CONFERENCE PRESENTATION: Nathan presents some of our first results imaging the inner retina in-vivo.
Imaging the Invisible: Imaging Individual Retinal Ganglion Cells in the Living Human Eye,” Prevent Blindness Ohio: Aging Eye Summit
PERSONNEL: Christi Locke receives Wallman scholarship
March 2018
PAPER: Elaine’s paper on our combined AO-OCT-SLO system published.
Volumetric imaging of rod and cone photoreceptor structure with a combined adaptive optics-optical coherence tomography-scanning laser ophthalmoscope. Journal of Biomedical Optics
January 2018
GRANT: Stacey awarded grant from the American Academy of Optometry (AAO) to study the Outer Retinal Changes in the Myopic Children
December 2017
GRANT: Nathan awarded a grant from the Ann Ellis Fund of the Columbus Foundation to further develop optical techniques to image the retinal ganglion cells in-vivo. Important in the study of glaucoma
CONFERENCE PRESENTATION: Nathan presents at the local Optometric Educators Inc. (OEI) Annual Winter Continuing Education Conference at Lewis Center
Imaging Retinal Disease with Adaptive Optics Optical Coherence Tomography
July 2017
GRANT: Stacey and Nathan are co-investigators on and OSU grant to study the Retinal changes in traumatic optic neuropathy. Collaboration with BME faculty, Matthew Reilly
June 2017
PERSONNEL: Christi Locke receives Wallman scholarship.
May 2017
CONFERENCE PRESENTATION: Off to Baltimore! Stacey and Elaine presenting at ARVO
Retinal Integrity after Short Wavelength Subthreshold Micropulse Laser Therapy for Diabetic Macular Edema
The effect of moderate myopia on rod and cone photoreceptor densities in human eyes using AO-SLO imaging
BOOK CHAPTER: Nathan authors the chapter “Adaptive Optics and OCT” for the book “Handbook of Visual Optics” Taylor and Francis Books.
LAB PERSONNEL: Winston Posvar successfully defends his MS thesis entitled “Variation of Ocular Parameters in Young Normal Eyes”
March 2017
PAPER: Stacey and Nathan are co-authors on Vision Science and Adaptive Optics: The State of the Field published in Vision Research
February 2017
CONFERENCE PRESENTATION: Elaine presents at Photonics West in San Francisco.
Investigation of retinal microstructure in healthy eyes and dry age-related macular degeneration using a combined AO-OCT-SLO system
August 2016
PAPER: Elaine’s paper on imaging the mid-periphery with AO is published in Eye.
Variation in rod and cone density from the fovea to the mid-periphery in healthy human retinas using adaptive optics scanning laser ophthalmoscopy
July 2016
CONFERENCE PRESENTATION: Nathan presents Integrity of Individual Cone Photoreceptors over Drusen in Early Stage Dry AMD at the Optometric Educators Inc. (OEI) Annual Summer Continuing Education Conference in Dublin, OH
June 2016
LAB PERSONNEL: Dr. Hugh Morris leaves to take teaching position in Columbus
May 2016
CONFERENCE PRESENTATION: Off to Seattle! Stacey, Nathan, Elaine and Hugh present at ARVO
In Vivo Visualization of Cone and Rod Photoreceptors in the Healthy Human Retina using a combined AO-OCT-SLO
Integrity of individual cone photoreceptors over drusen in early stage dry AMD
Is the retina affected in chronic form of mild traumatic brain injury with binocular vision problems?
Factors Affecting the Magnitude of Cone Directionality in the Stiles-Crawford Effect of the First Kind
LAB PERSONNEL: Stacey elected to the ARVO Annual Meeting Program Committee, Multidisciplinary Ophthalmic Imaging Cross-sectional Group (MOI) for a 3 year term
LAB PERSONNEL: Christi Locke joins the lab as an OD/MS student
December 2015
PAPER: Hugh’s work on the SCE in the parafovea is published in Vision Research.
Directionality of Individual Cone Photoreceptors in the Parafoveal Region Vision Research
October 2015
CONFERENCE PRESENTATION: Do you know the way to San Jose? Nathan has an invited talks at the Optical Society of America (OSA) Frontiers in Optics APS/DLS
Retinal Imaging and Cone Pointing Measurements in the Living Chick Eye
Modeling High-Resolution SLO and OCT Retinal Imaging using Backscattering of Light from Elementary Sources
September 2015
PAPER: Novel method to measure the SCE in human eyes
Rapid measurement of individual cone photoreceptor pointing using focus diversity Optics Letters
May 2015
CONFERENCE PRESENTATION: Elaine is off to Denver for ARVO
Characterization of Human Photoreceptor Packing Arrangement as a Function of Retinal Eccentricity using an Adaptive Optics Scanning Laser Ophthalmoscope (AO-SLO)
April 2015
LECTURE: Off to see the Hoosiers. Nathan to give presentation at the School of Optometry, Indiana University.
March 2015
PAPER: In conjunction with our University of Arizona collaborator, Dr. John Codona. Co-phasing the James Webb space telescope.
James Webb Space Telescope Segment Phasing using Differential Optical Transfer Functions. Journal of Astronomical Telescopes, Instruments, and Systems
Made the cover as well!!
February 2015
PAPER: Maria’s MS work measuring cone properties in the chick eye is out
Measurement of the Photoreceptor Pointing in the Living Chick Eye. Vision Research
CONFERENCE PRESENTATION: Elaine is off to San Francisco for Photonics West
Performance of a combined optical coherence tomography and scanning laser ophthalmoscope with adaptive optics for human retinal imaging applications
October 2014
LAB PERSONNEL: Dr. Hugh Morris joins as a postdoctoral fellow from OSU BME Dept. Welcome!
July 2014
CONFERENCE PRESENTATION: Nathan presents ”High Resolution Retinal Imaging,” at the Optometric Educators Inc. (OEI) Annual Summer Continuing Education Conference , Dublin, OH
LAB PERSONNEL: Postdoc Dr. Leonardo Blanco off to the French National Center for Scientific Research (CNRS)
May 2014
CONFERENCE PRESENTATION: Off to Orlando for ARVO
Rapid Measurement of Cone Photoreceptor Pointing using Focus Diversity
In-vivo, Imaging of Human Cone Photoreceptors without the Use of Adaptive Optics
LAB PERSONNEL: Winston Posvar joins the lab as a combined OD/MS student
October 2013
CONFERENCE PRESENTATION: Lindsey and Leo present at the Academy of Optometry meeting in Seattle
Optical Waveguide Properties of Individual Cone Photoreceptors at Various Retinal Eccentricities
Cone Density and Packing Characteristics in Treated Amblyopic Eyes
August 2013
LAB PERSONNEL: Dr. Elaine Wells Gray joins as a postdoctoral fellow from the University of Oregon. Welcome!
July 2013
MAJOR NEWS: Laboratory moving from Boston to the College of Optometry at the Ohio State University
June 2013
LAB PERSONNEL: Dr. Susanna Finn off to take a Research Scientist position at u Mass Lowell
May 2013
CONFERENCE PRESENTATION: In Seattle for the ARVO Annual Meeting, several presentations
Photoreceptor Pointing as a Function of Retinal Eccentricity in Normal Human Eyes
Measurement of the Photoreceptor Pointing in the Living Chick Eye
AO-OCT Retinal Imaging with 163-Segment Deformable Mirror
CONFERENCE PRESENTATION: OD/MS student Jennifer Choi to present at the ARVO meeting in Fort Lauderdale
Future Insights on an Ocular Hypertension Model in the White Leghorn Chicken
LAB PERSONNEL: Jennifer Choi successfully defends her MS thesis entitled “Age-related changes of ocular dimensions in white leghorn chicken with additional insights on an ocular hypertension model in the chicken”
LAB PERSONNEL: Maria Walker successfully defends her MS thesis entitled “Measurement of the Photoreceptor Pointing in the Living Chick Eye”. Currently an Assistant Clinical Professor at the University of Houston College of Optometry
February 2013
CONFERENCE PRESENTATION: Cherry and John give a presentation at Photonics West
Characterization of a MEMs deformable mirror by far field intensity evaluation
Volumetric imaging of the intraocular propagation medium using differential OTF wavefront sensing
LAB PERSONNEL: Dr. Leonardo Blanco joins as a postdoctoral fellow from ONERA and the Observatoire de Paris. Welcome!
LAB PERSONNEL: Dr. Cherry Greiner off to take position as a Senior Research Associate at InfraReDx
January 2013
PAPER: Clinical Applications of High Resolution In-Vivo Retinal Imaging. Journal of Ophthalmology. Editorial
PAPER: Photoreceptor Imaging. Ophthalmology.
October 2012
CONFERENCE PRESENTATION: Lindsey to present at the Academy of Optometry meeting in Phoenix
Inner retinal characteristics in treated amblyopic eyes
September 2012
LAB PERSONNEL: Kenneth Headington awarded the 2012 Neumueller Award from the American Academy of Optometry (AAO) for his MS research
July 2012
CONFERENCE PRESENTATION: Collaborator Dr. Codona gives presentation at “Adaptive Optics Systems III” SPIE in Amsterdam, Netherlands
Experimental evaluation of differential OTF (dOTF) wavefront sensing
June 2012
LAB PERSONNEL: Dr. Fuensanta Vera Diaz to join the faculty at the New England College of Optometry. Congratulations!
May 2012
BOOK CHAPTER: Nathan authors the chapters “MEMS Adaptive Optics” for the book “Encyclopedia of Nanotechnology” through Springer Science + Business Media
CONFERENCE PRESENTATION: OD/MS student Jennifer Choi to present at the ARVO meeting in Fort Lauderdale
Age-Related Changes in Ocular Parameters in White Leghorn Chickens
LAB PERSONNEL: Kenneth Headington successfully defends his MS thesis entitled “High Resolution Imaging of the Chick Retina using Adaptive Optics”
January 2012
BOOK CHAPTER: Fuensanta and Nathan author the book chapter “The Human Eye and Adaptive Optics” for the book “Topics in Adaptive Optics” Intech Publishing
BOOK CHAPTER: Cherry and Stacey author the book chapter “Cellular Level Imaging of the Retina using Optical Coherence Tomography”, for the book “Optical Coherence Tomography” Intech Publishing
November 2011
LAB PERSONNEL: Dr. Susanna Finn joins as a postdoctoral fellow from Boston University. Welcome!
October 2011
PAPER: Ken’s MS research work imaging the photoreceptors in the chick eye is published in Current Eye Research
Single Cell, In vivo Imaging of the Chick Retina with Adaptive Optics
August 2011
LAB PERSONNEL: Dr. Yicong Zhou to take faculty position at the University of Macau
May 2011
CONFERENCE PRESENTATION: Lindsey to present at ARVO meeting in Phoenix
Investigation of Outer Retinal Differences In Amblyopic Eyes
March 2011
PAPER: Stacey a co-author on an invited paper to Eye.
Outer retinal abnormalities associated with inner retinal pathology in non-glaucomatous and glaucomatous optic neuropathies
February 2011
LECTURE: Nathan to present at the Massachusetts Society of Optometrists (MSO), Southborough, MA
Application of Adaptive Optics to Retinal Imaging and Vision Testing
LAB PERSONNEL: Dr. Cherry Greiner joins as a postdoctoral fellow from Tufts University. Welcome!
January 2011
PAPER: Our lab publishes the images of the rod receptors in the living human eye!
In vivo imaging of the human rod photoreceptor mosaic. Optics Letters
PAPER: Photoreceptor changes in glaucoma
Evidence of outer retinal changes in glaucoma patients as revealed by ultrahigh-resolution in vivo retinal imaging. British Journal of Ophthalmology
PAPER: Stacey is a co-author on a paper describing OCT imaging of epi-retinal membranes published in Eye
Fourier-domain optical coherence tomography of eyes with idiopathic epi-retinal membrane: correlation between macular morphology and visual function
October 2010
GRANT: Stacey awarded 4 year grant from the US Department of Defense (US Army) to use high resolution imaging of the human retina as a direct, non-invasive biomarker for blast traumatic brain injury (TBI)
Ultrahigh Resolution Retinal Imaging with Adaptive Optics for Early Diagnosis of Traumatic Brain Injury
September 2010
LECTURE: Off to MIT. Nathan to present at the Media Lab
Adaptive Optics for High Resolution Retinal Imaging
LAB PERSONNEL: Dr. Fuensanta Vera Diaz joins the lab as an assistant research professor Sept 2010 – Jun 2012
PAPER: The oblique effect has an optical component; orientation-specific contrast thresholds after correction of high-order aberrations. Journal of Vision
August 2010
PAPER: High-resolution Fourier-domain optical coherence tomography of choroidal neovascular membranes associated with age-related macular degeneration. Investigative Ophthalmolology and Visual Science
July 2010
GRANT: Nathan awarded 5 year RO1 grant from the National Institute of Health – National Eye Institute (NEI) to develop optical techniques to image the rod photoreceptors in vivo
In-vivo, High Contrast Imaging of the Human Rod Photoreceptor Mosaic
June 2010
PAPER: Stacey is a co-author of a paper describing the retinal effects of tamoxifen treatment for breast cancer. Published in Retinal Cases & Brief Reports.
Maculopathy diagnosed with high-resolution Fourier-domain optical coherence tomography in eyes with previously unexplained visual loss
May 2010
CONFERENCE PRESENTATION: OD/MS student Ken Headington to present at the ARVO meeting in Fort Lauderdale.
Single Cell, In-Vivo Imaging of Chick Retina with Adaptive Optics
CONFERENCE PRESENTATION: Stacey to present at the ARVO meeting in Fort Lauderdale.
A Close-Up Investigation of Cone Photoreceptors in Retinal and Optic Nerve Diseases as Revealed by Adaptive Optics – OCT Images
March 2010
PAPER: Microstructural abnormalities revealed by high resolution imaging systems in central macular arteriovenous malformation. Ophthalmic Surgery, Lasers & Imaging
Jan 2010
LAB PERSONNEL: Maria Walker joins the lab as an OD/MS student