Publications

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Ma H*, Tu LC*, Chung YC*, Naseri A, Grunwald D, Zhang S, Pederson T. (2019) Cell cycle- and genomic distance-dependent dynamics of a discrete chromosomal region. J Cell Biol. 218(5): 1467-1477.

Tu LC*, Huisman M*, Chung YC*, Smith C, Grunwald D. (2018) Deconstructing transport distribution reconstruction in the nuclear-pore complex Nat. Struct. Mol. Biol. 25(12):1061-1062.

Ma H, Tu LC, Naseri A, Chung YC, Grunwald D, Zhang S, Pederson T. (2018) CRISPR-Sirius: RNA scaffolds for signal amplification in genome imaging. Nat Methods. 15(11):928-931.

Gao XD, Tu LC, Mir A, Dekker J, Shaffer SA, Zhu LJ, Wolfe SA, Sontheimer EJ. (2018) C-BERST: Defining subnuclear proteomic landscapes at genomic elements with dCas9-APEX2. Nat Methods. 15(6):433-436

Fu G, Tu LC, Zilman A, Musser SM. (2017) Investigating molecular crowding within nuclear pores using polarization-PALM. eLife September 26; 6: e28716

Ma H*, Tu LC*, Naseri A, Huisman M, Zhang S, Wolfe S, Grunwald D, Pederson T. (2016) CRISPRCas9 nuclear dynamics and target recognition in living cells. J Cell Biol. 214(5): 529-537. Recommended by F1000Prime and Highlighted in the In Focus section in J. Cell Biol

Ma H, Tu LC, Naseri A, Huisman M, Grunwald D, Zhang S, Pederson T. (2016) Multiplexed labeling of genomic loci with dCas9 and engineered sgRNA using CRISPRainbow. Nat. Biotechnol. 34(5): 528-30. Highlighted on the NIH 4D Nucleome webpage

Smith C, Tu LC, Grunwald D. (2015). A 4D view on mRNA. Oncotarget 6: 28515-28516

Tu LC, Fu G, Zilman A, Musser SM. (2013) Large cargo transport by nuclear pores: implications for the spatial organization of FG-nucleoporins. EMBO J. 32:3220-3230.

Tu LC, Musser SM. (2011) Single molecule studies of nucleocytoplasmic transport. Biochim Biophys Acta – Mol. Cell Research. 1813: 1607-1618

Sun C, Yang W, Tu LC, Musser SM. (2008) Single-molecule measurements of importin alpha/cargo complex dissociation at the nuclear pore. Proc Natl Acad Sci USA. 105: 8613-8618

Ng KY, Tu LC, Wang YS, Chan SI, Yu SS. (2008) Probing the hydrophobic pocket of the active site in the particulate methane monooxygenase (pMMO) from Methylococcus capsulatus (Bath) by variable stereoselective alkane hydroxylation and olefin epoxidation. Chembiochem. 9: 1116-1123.