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 Dr. Zucai Suo – Principal Investigator

Professor of Chemistry & Biochemistry 

Office: 880 Biological Sciences Building

Phone: 614-688-3706

E-mail: suo.3@osu.edu

Available Postdoctoral Position in Single-Molecule Flurorescence Systems

One postdoctoral position is available immediately in an enzymology laboratory to elucidate the kinetics and dynamics of DNA lesion bypass and base excision repair catalyzed by human enzymes using single molecule Prism-based Total Internal Reflection Fluorescence (TIRF) apparatus. Background in single molecule TIRF technologies, computer programming, enzyme kinetics, biophysics, and protein purification is preferred. An important criterion for selection will be the ability of the desired individual to pursue independent research in an active multi-disciplinary setting. Interested candidates should send a cover letter, CV, and arrange to have three letters of recommendation sent to: Dr. Zucai Suo, Eminent Professor and Dorian and John Blackmon Chair of Biomedical Science, Department of Biomedical Sciences, College of Medicine, Florida State University. Dr. Suo can be contacted by email (zucai.suo@med.fsu.edu) or phone (850-645-2501). Further information about the research projects in the Suo Lab can be obtained from https://u.osu.edu/suolab/.

Suo Lab 2017

Recent New, Awards, and Recognition

Our recent publication in JACS, “Sharpening the Scissors: Mechanistic Details of CRISPR/Cas9 Improve Functional Understanding and Inspire Future Research”, has been highlighted in a JACS Spotlight. [JACS Spotlight]

Madison smith has been awarded the Mayer’s Undergraduate Research Summer Fellowship from the Ohio State University for the 2018 summer.

Madison Smith placed 3rd in the Molecular Biophysics & Chemical Biology category of the Ohio State University Denman Undergraduate Research Forum Poster Session.

Jack Tokarsky was awarded the Dr. Robin C. Burrell Memorial Fund to attend the 256th ACS National Meeting & Exposition in Boston, Mass. (August 19th to 23rd, 2018) and will be presenting his work.

Our recent publication in JACS, “Functional Insights Revealed by the Kinetic Mechanism of CRISPR/Cas9” has been recommended in F1000Prime. [F1000 Recommendation]

Madison Smith has been awarded The Kraska Scholarship from the Ohio State University Chemistry and Biochemistry Department for the 2018-2019 year.

Jennifer Tuokkola has been awarded the Bertram Thomas Memorial Fund Scholarship from the Ohio State University Chemistry and Biochemistry Department for the 2018-2019 year.

Our recent publications in JACS regarding the mechanism and new activity of CRISPR/Cas9 have been featured in a JACS Spotlight. [JACS Spotlight]

Our recent publication in Nature, “Dynamic basis for dG•dT misincorporation via tautomerization and ionization”, has been recommended in F1000Prime as being of special significance in its field. [F1000 Recommendation]

The Suo lab has recently published two articles in the Journal of the American Chemical Society detailing the kinetic mechanism of CRISPR/Cas9 as well as identifying and characterizing a novel activity of Cas9. [Kinetic Mechanism Publication][New Activity Publication] [Press Release]

Former graduate student Dr. Kevin Fiala has passed the Bar exam and is now a patent attorney at Womble Bond Dickinson LLP.

Dr. Suo and Walter Zahurancik, in collaboration with Dr. Al-Hashimi’s lab at Duke University, have published a research article in Nature entitled: “Dynamic basis for dG•dT misincorporation via tautomerization and ionization”. [Online Access] [OSU Press Release] [Duke Press Release][Myron Goodman Commentary in Nature]

Dr. Suo and Walter Zahurancik’s publication in Cell, “Comprehensive analysis of hypermutation in human cancer”, has been highlighted in a commentary also published in Cell. [Commentary in Cell]

Former Suo Lab graduate student Dr. Jason Fowler has been promoted as of 2017 to Associate Professor with tenure at Lincoln Memorial University.

Our 2017 publication in Aids Research and Human Retroviruses, “Long-term survival of AIDS patients treated with only traditional Chinese medicine”, has become the No. 1 most downloaded publication of that journal in the past 12 months (as of December 2017).

Former Postdoctoral Researcher Dr. Rajan Vyas has been awarded the 2017 Ramalingaswami Re-entry Fellowship, which is given to Indian nationals who have conducted research overseas and demonstrated an excellent publication and achievement track record. The Fellowship provides senior researcher status and stipend for those researchers who are returning to India for faculty positions.

Andrew Reed has placed 2nd in the 2017 Dow Chemical Poster Competition at The Ohio State University.

Madison Smith placed 2nd in the Science division for the 3 minute undergraduate thesis competition (2017).

Madison Smith has been awarded a 2017 ASC Undergraduate Research Scholarship for her proposed work in Dr. Suo’s lab.

Dr. Suo has served as the secretary for the Division of Chemical Toxicology of the American Chemical Society since January 2016 and has just been elected to the position of treasurer starting in 2020.

Congrats to Walter Zahurancik for being awarded the Graduate School’s Louise B. Vetter Award, which is sponsored by the Ohio State chapter of the Honor Society of Phi Kappa Phi and is given for excellence in research among Presidential Fellows!

Walter Zahurancik and Dr. Suo are co-authors on a manuscript published in Cell (Oct. 2017).

Congrats to Andrew Reed for finishing the 45 mile ride for Pelotonia 2017!

Austin Raper has been awarded the runner up award for his oral presentation at the annual Interdisciplinary Graduate Program symposium.

Dr. Suo has been awarded the 2017 Okeanos-CAPA (Chinese-American Chemistry & Chemical Biology Professors Association) Senior Investigator Award.

Andrew Reed has been awarded the 2017 Graduate Student Pelotonia Fellowship.

Jack Tokarsky has been awarded the 2017 Robert Ross Lecture Biophysics Outstanding Student Award for outstanding academic achievements in the Biophysics Graduate Program.

Walter Zahurancik has been awarded the 2017 Presidential Fellowship from The Ohio State University.

Madison Smith has been awarded the Kraska Scholarship from the Chemistry department for the 2017-2018 academic year.

Varun Gadkari successfully defended his Ph.D. thesis and will graduate this May.

Former Suo Lab graduate student Dr. Shanen Sherrer has accepted a faculty position at St. Mary’s College of Maryland in the Department of Biochemistry.

Austin Raper has been awarded the 2017 Presidential Fellowship from The Ohio State University

Congratulations to Walter on finishing the 50 mile Pelotonia Bike Ride on August 7th, 2016!

Former Suo Lab graduate student Dr. Jessica Brown has accepted a faculty position at the University of Notre Dame in the Department of Chemistry & Biochemistry. [New Faculty Announcement]

Our 2015 publication in JACS, “Viewing Human DNA Polymerase β Faithfully and Unfaithfully Bypass an Oxidative Lesion by Time-Dependent Crystallography,” has been featured in the April 26th, 2016 edition of APS Science Highlight. [Online Access]

Kenny Phi placed 3rd in the Biological Sciences division at the 2016 Denman Undergraduate Research Forum.

Former Suo Lab graduate student Dr. Brian Maxwell has been awarded the Ruth L. Kirschstein NRSA Award by the National Institutes of Health.

Shelby Newsad has been selected as a semifinalist for the Fulbright Scholar Program for the 2016-2017 year.

Austin Raper received an honorable mention for his poster at the 2015 Dow Graduate Student Poster Session

Access the recommendation on F1000Prime

Our recent publication in JACS, “Mechanistic Basis for the Bypass of a Bulky DNA Adduct Catalyzed by a Y-Family DNA Polymerase,” has been recommended in F1000Prime  as being of special significance in its field.

OurAccess the recommendation on F1000Prime recent publication in JACS, “Viewing Human DNA Polymerase β Faithfully and Unfaithfully Bypass an Oxidative Lesion by Time-Dependent Crystallography,” has been recommended in F1000Prime  as being of special significance in its field.

Former Suo Lab graduate student Dr. Brian Maxwell has been awarded the George Mitchell Endowed Fellowship from St. Jude Children’s Research Hospital.  This is prestigious award is given to only one Postdoctoral Researcher every year.

Austin Raper has been awarded a 2015 Chemistry Biology Interface Program Fellowship.

Austin Raper was awarded the 1st place prize for his poster presentation “Dynamic Damage Searching and Substrate Processing by Base Excision Repair Enzymes” at the 2015 IGP Symposium.

Walter Zahurancik has been awarded a 2015 Pelotonia Fellowship.

Austin Raper has been nominated for the 2015 Center for Life Sciences Education Outstanding TA Award for his excellence in teaching.

Kenny Phi has been awarded the Undergraduate Research Scholarship for the 2015-2016 academic year by the College of Arts & Sciences Honors Committee.

Kenny Phi has been awarded The Department of Chemistry & Biochemistry Gary Booth Scholarship for the 2015-2016 academic year.

Former Suo Lab graduate student Dr. Jessica Brown has been awarded an NIH Pathway To Independence (K99) Award

Dr. Suo was elected as a Fellow of the American Association for the Advancement of Science (AAAS) for distinguished contributions to the field of nucleic acid enzymology, particularly for pre-steady state kinetic and protein conformational dynamic studies of DNA polymerases. Read more