Mathematical Methods for Genetix

Principal Investigator: BCMM at The Research Institute at  Nationwide Children’s Hospital, 575 Children’s Crossroad | Columbus, Ohio | 43215


Assistant Professor of Statistics, College of Arts & Sciences, Assistant Professor of Pediatrics, College of Medicine, The Ohio State University, Enarson Hall, 154 W. 12th Ave. | Columbus, Ohio | 43210-1390

I develop statistical methods for researchers who seek quick and efficient analyses of new and computationally challenging data. Consequently, I am interested in developing methods for newly emerging data types that are motivated by scientific discovery (e.g. SNP intensity data of related individuals). Using both family and population based data, I have developed improved methods for mapping genetic risk variants for psychiatric disorders (e.g. genes and CNVs related to Alzheimer’s disease and bipolar disorder, respectively), and for estimating genetic maps by combining information efficiently from multiple studies (i.e. meta-analyses). In addition, I have a general interest in deterministic math models, gene networks, and problems that arise in computational molecular biology. Most of my methods employ a rich variety of deterministic and stochastic algorithms, Monte Carlo sampling techniques, and various optimization procedures to estimate genetic quantities of interest (e.g. lod socres, kinships, CNV frequencies and carrier status) in fairly general settings.

For more details, see my other pages (left menu) : EAGLET, POPFAM+, HEMIZYG, etc…

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