The lab investigates the machineries that duplicate, express, organize and segregate the genome. To ensure viability, all cells must perform these processes in a timely and accurate manner. We exploit a multi-disciplinary range of cell and molecular biological, biochemical, genetic and structural approaches to determine the mechanistic and regulatory parameters that govern these essential cellular processes. Our work is driven by the evolutionary conservation of these fundamental machineries, allowing us to exploit archaea of the genus Sulfolobus as simple and robust model organisms.
NEWS:
A collaboration with Fabai Wu (Eastern Institute of Technology, Ningbo) that describes the evolution of the DNA replication machinery in Asgard archaea has just been published in Nature Ecology and Evolution.
A manuscript by graduate student Rajkumar Dhanaraju describing the novel origin-interacting factor, UBP, has been published in Nature Communications.
Rylee Hackley has been awarded a President’s Postdoctoral Scholar Program Fellowship.