August 3, 2016 in BRT 134

The next Retrovirology Journal Club is Wednesday, August 3 at 5:00 pm in BRT 134. You do not need security access to get to this room. If you would like to volunteer to present at any future date, please let me know. (Please volunteer for a date!)

Corine St. Gelais, PhD, (Wu lab) will be presenting. A pdf is attached for your convenience.080316retroJC

“HIV-1 and HIV-2 exhibit divergent interactions with HLTG and UNG2 DNA repair proteins”
Hrecka et al 2016 PNAS 113:E3921

HIV infection and heart disease

A recent paper in the International Journal of Cardiology compared the occurrence of heart disease of in 36,400 HIV patients and over 12 million control patients. The authors from Case Western Reserve University in Cleveland found that even when HIV patients are receiving anti-retroviral therapy, they are more likely to suffer heart failure. Interestingly, women and younger patients were more likely to have heart failure. Sadly, the authors conclude that the HIV patients in the study were less likely to receive optimal treatment for their heart disease.

“Heart failure in patients with human immunodeficiency virus infection: Epidemiology and management disparities” Al-Kindi, SG, C ElAmm, M Ginwalla, E Mehanna, M Zacharias, R Benatti, GH Oliveira, and CT Longenecker. International Journal of Cardiology. v. 218. pp 43-46.



Persons living with HIV are at a higher risk of cardiovascular disease despite effective antiretroviral therapy and dramatic reductions in AIDS-related conditions. We sought to identify the epidemiology of heart failure (HF) among persons living with HIV in the United States in an era of contemporary antiretroviral therapy.


Explorys is an electronic healthcare database that aggregates medical records from 23 healthcare systems nationwide. Using systemized nomenclature of medicine-clinical terms (SNOMED-CT), we identified adult patients (age>18), who had active records over the past year (September 2014-September 2015). We described the prevalence of HF in HIV patients by demographics and treatment and compared them to HIV-uninfected controls.


Overall, there were 36,400 patients with HIV and 12,208,430 controls. The overall prevalence of HF was 7.2% in HIV and 4.4% in controls (RR 1.66 [1.60-1.72], p<0.0001). The relative risk of HF associated with HIV infection was higher among women and younger age groups. Patients receiving antiretroviral therapy had only marginally lower risk (6.4% vs. 7.7%, p<0.0001) of HF compared to those who were untreated. Compared to uninfected patients with HF, HIV patients with HF were less likely to receive antiplatelet drugs, statins, diuretics, and ACE/ARBs (p<0.0001 for all comparisons). For patients with HIV and HF, receiving care from a cardiologist was associated with higher use of antiplatelets, statins, betablockers, ACE/ARBs, and diuretics.


Persons with HIV are at higher risk for HF in this large contemporary sample that includes both men and women. Although the prevalence of heart failure is higher in older HIV patients, the relative risk associated with HIV is highest in young people and in women. HIV patients are less likely to have HF optimally treated, but cardiology referral was associated with higher treatment rates.

July 6, 2016 in BRT 130

The paper for July 6, 2016 is “PD-1+ and follicular helper T cells are responsible for persistent HIV-1 transcription in treated aviremic individuals” Nature Medicine 2016 by Banga et al. Our presenter will be Ashley Hoyte from the Kvaratskhelia lab.

A pdf is attached for journal club participants. 070616retroJC

Please volunteer to present at an upcoming date!