Oestreich Lab Publications

Jones, D.M.*, J.A. Tuazon*, K.A. Read, M.R. Leonard, S. Pokhrel, B.K. Sreekumar, R.T. Warren, J.S. Yount, P.L. Collins, K.J. Oestreich. 2024. Cytotoxic Programming of CD4+ T Cells is Regulated by Opposing Actions of the Related Transcription Factors Eos and Aiolos. J Immunol. 2024 Feb 16. *Co-First Authors

Gutierrez F., Q.M. Murphy, B.K. Swartwout, K.A. Read, M.R. Edwards, L. Abdelhamid, X. Cabana-Puig, J.C. Testerman, T. Xu, R. Lu, P. Amin, T.E. Cecere, C.M. Reilly, K.J. Oestreich, S.M. Ciupe, X.M. Luo. 2024. TCDD and CH223191 Alter T Cell Balance but Fail to Induce Anti-Inflammatory Response in Adult Lupus Mice. Immunohorizons. 2024 Feb 1.

Tuazon, JA., K.A. Read, B.K. Sreekumar, J.E. Roettger, M.J. Yaeger, S. Varikuti, S. Pokhrel, D.M. Jones, R.T. Warren, M.D. Powell, M.N. Rasheed, E.G. Duncan, L.M. Childs, K.M. Gowdy, K.J. Oestreich. 2023. Eos Promotes TH2 Differentiation by Interacting with and Propagating the Activity of STAT5. J Immunol. 2023 Aug 1.

Shamseldin, M.M., A. Kenney, A. Zani, J.P., Evans, C. Zeng, K.A. Read, J.M. Hall, S. Chaiwatpongsakorn, K.C. Mahesh, M. Lu, M. Eltobgy, P. Denz, R. Deora, J. Li, M.E. Peeples, K.J. Oestreich, S. Liu, K.N. Corps, J.S. Yount, P. Dubey. 2023. Prime-Pull Immunization of Mice with a BcfA-Adjuvanted Vaccine Elicits Sustained Mucosal Immunity That Prevents SARS-CoV-2 Infection and Pathology. J Immunol. 2023 May 1.

Read, K.A.*, D.M. Jones*, S. Pokhrel, E.D.S. Hales, A. Varkey, J.A. Tuazon, C.D. Eisele, O. Abdouni, A. Saadey, R.T. Warren, M.D. Powell, J.M. Boss, E.A. Hemann, J.S. Yount, H.E. Ghoneim, C.J. Lio, A.G. Freud, P.L. Collins, K.J. Oestreich. 2023. Aiolos represses CD4+ T cell cytotoxic programming via reciprocal regulation of TFH transcription factors and IL-2 sensitivity. Nat Commun. 2023 Mar 24. *Co-First Authors

Zhao B, Gong W, Ma A, Chen J, Velegraki M, Dong H, Liu Z, Wang L, Okimoto T, Jones DM, Lei YL, Long M, Oestreich KJ, Ma Q, Xin G, Carbone DP, He K, Li Z, Wen H. SUSD2 suppresses CD8+ T cell antitumor immunity by targeting IL-2 receptor signaling. Nat Immunol. 2022 Nov

Gunasena, M., R.K., Shukla, N. Yao, O.R. Mejia, M.D. Powell, K.J. estreich, M.J. Aceves-Sanchez, M.A. Flores-Valdez, N.P.M. Liyanage, R.T. Robinson. 2022. Evaluation of early innate and adaptive immune responses to the TB vaccine Mycobacterium bovis BCG and vaccine candidate BCGΔBCG1419C. Sci Rep. 2022 July 20.

Shamseldin MM, Kenney A, Zani A, Evans JP, Zeng C, Read KA, Hall JM, Chaiwatpongsakorn S, Mahesh KC, Lu M, Eltobgy M, Denz P, Deora R, Li J, Peeples ME, Oestreich KJ, Liu SL, Corps KN, Yount JS, Dubey P. Prime-Pull Immunization of Mice with a BcfA-Adjuvanted Vaccine Elicits Sustained Mucosal Immunity That Prevents SARS-CoV-2 Infection and Pathology. J Immunol. 2023 May 1

Tuazon, J.A., B. Kilburg-Basnyat, L.M. Oldfield, R. Wiscovitch-Russo, K. Dunigan-Russell, A.V. Fedulov, K.J. Oestreich, K.M. Gowdy. 2022. Emerging Insights into the Impact of Air Pollution on Immune-Mediated Asthma Pathogenesis. Curr Allergy Asthma Rep. 2022 Apr 8.

Payne, L.B.,  B.P. Tewari, L. Dunkenberger, S. Bond, A. Savelli, J. Darden, H. Zhao, C. Willi, R. Kanodia, R. Gude, M. D. Powell, K. J. Oestreich, H. Sontheimer, S. Dal-Pra, J.C. Chappell. 2022. Pericyte Progenitor Coupling to the Emerging Endothelium During Vasculogenesis via Connexin 43. Arteriosclerosis, Thrombosis, and Vascular Biology. 2022;42:e96–e114

Read, K.A., K.J. Oestreich. 2021. Making memories with Bcl6. J Exp Med (2022) 219 (1): e20212177.

Read, K. A., D. M. Jones, A. G. Freud, and K. J. Oestreich. 2021. Established and emergent roles for Ikaros transcription factors in lymphoid cell development and function. Immunol Rev 300: 82-99.

Pal, A., K. M. Gowdy, K. J. Oestreich, M. Beck, and S. R. Shaikh. 2020. Obesity-Driven Deficiencies of Specialized Pro-resolving Mediators May Drive Adverse Outcomes During SARS-CoV-2 Infection. Front Immunol 11: 1997.

Jones, D. M., K. A. Read, and K. J. Oestreich. 2020. Dynamic Roles for IL-2-STAT5 Signaling in Effector and Regulatory CD4(+) T Cell Populations. J Immunol 205: 1721- 1730.

Papillion, A., M. D. Powell, D. A. Chisolm, H. Bachus, M. J. Fuller, A. S. Weinmann, A. Villarino, J. J. O’Shea, B. Leon, K. J. Oestreich, and A. Ballesteros-Tato. 2019. Inhibition of IL-2 responsiveness by IL-6 is required for the generation of GC-TFH cells. Sci Immunol 4.

Powell, M. D., K. A. Read, B. K. Sreekumar, D. M. Jones, and K. J. Oestreich. 2019. IL-12 signaling drives the differentiation and function of a TH1-derived TFH1-like cell population. Sci Rep 9: 13991.

Ringel-Scaia, V. M., M. D. Powell, K. A. Read, I. C. Allen, and K. J. Oestreich. 2019. Systemic Listeria monocytogenes Infection as a Model to Study T Helper Cell Immune Responses. Methods Mol Biol 1960: 149-160.

Ringel-Scaia, V. M., N. Beitel-White, M. F. Lorenzo, R. M. Brock, K. E. Huie, S. Coutermarsh-Ott, K. Eden, D. K. McDaniel, S. S. Verbridge, J. H. Rossmeisl, Jr., K. J. Oestreich, R. V. Davalos, and I. C. Allen. 2019. High-frequency irreversible electroporation is an effective tumor ablation strategy that induces immunologic cell death and promotes systemic anti-tumor immunity. EBioMedicine 44: 112-125.

Read, K. A., M. D. Powell, B. K. Sreekumar, and K. J. Oestreich. 2019. In Vitro Differentiation of Effector CD4(+) T Helper Cell Subsets. Methods Mol Biol 1960: 75-84.

Powell, M. D., K. A. Read, B. K. Sreekumar, and K. J. Oestreich. 2019. Ikaros Zinc Finger Transcription Factors: Regulators of Cytokine Signaling Pathways and CD4(+) T Helper Cell Differentiation. Front Immunol 10: 1299.

Cesewski, E., A. P. Haring, Y. Tong, M. Singh, R. Thakur, S. Laheri, K. A. Read, M. D. Powell, K. J. Oestreich, and B. N. Johnson. 2018. Additive manufacturing of three- dimensional (3D) microfluidic-based microelectromechanical systems (MEMS) for acoustofluidic applications. Lab Chip 18: 2087-2098.

Read, K. A., M. D. Powell, C. E. Baker, B. K. Sreekumar, V. M. Ringel-Scaia, H. Bachus, R. E. Martin, I. D. Cooley, I. C. Allen, A. Ballesteros-Tato, and K. J. Oestreich. 2017. Integrated STAT3 and Ikaros Zinc Finger Transcription Factor Activities Regulate Bcl-6 Expression in CD4(+) Th Cells. J Immunol 199: 2377-2387.

Mu, Q., H. Zhang, X. Liao, K. Lin, H. Liu, M. R. Edwards, S. A. Ahmed, R. Yuan, L. Li, T. E. Cecere, D. B. Branson, J. L. Kirby, P. Goswami, C. M. Leeth, K. A. Read, K. J. Oestreich, M. D. Vieson, C. M. Reilly, and X. M. Luo. 2017. Control of lupus nephritis by changes of gut microbiota. Microbiome 5: 73.

McDaniel, D. K., A. Jo, V. M. Ringel-Scaia, S. Coutermarsh-Ott, D. E. Rothschild, M. D. Powell, R. Zhang, T. E. Long, K. J. Oestreich, J. S. Riffle, R. M. Davis, and I. C. Allen. 2017. TIPS pentacene loaded PEO-PDLLA core-shell nanoparticles have similar cellular uptake dynamics in M1 and M2 macrophages and in corresponding in vivo microenvironments. Nanomedicine 13: 1255-1266.

McDonald, P. W., K. A. Read, C. E. Baker, A. E. Anderson, M. D. Powell, A. Ballesteros- Tato, and K. J. Oestreich. 2016. IL-7 signalling represses Bcl-6 and the TFH gene program. Nat Commun 7: 10285.

Read, K.A., M.D. Powell, and K.J. OestreichT follicular helper (TFH) cell programming by cytokine-mediated events.  Immunology. 149: 253-261 (2016). PMCID: PMC5046059.

Read, K.A., M.D. Powell, P.W. McDonald, and K.J. OestreichIL-2, IL-7, and IL-15: Multistage    regulators of CD4+ T helper cell differentiation.  Experimental Hematology. 44: 799-808 (2016). PMID: 27423815.

Cooley, I.D., K.A. Read, and K.J. OestreichTrans-presentation of IL-15 modulates STAT5 activation and Bcl-6 expression in TH1 cells.  Scientific Reports. 5: 15722 (2015). PMCID: PMC4620557.

Oestreich, K.J.*, K.A. Read, S.E. Gilbertson, K.P. Hough, P.W. McDonald, V. Krishnamoorthy, and A.S. Weinmann*.  Bcl-6 directly represses the glycolysis pathway gene program.  Nature Immunology. 15: 957-964 (2014). PMCID: PMC4226759.
*corresponding authors

Additional Selected Publications by Dr. Oestreich

Oestreich KJ, Weinmann AS. (2012). Master regulators or lineage-specifying? Changing views on CD4+ T cell transcription factors. Nat Rev Immunol 12, 799-804.

Oestreich KJ, Weinmann AS. (2012). Transcriptional mechanisms that regulate T helper 1 cell differentiation. Curr Opin Immunol 24(2), 191-5.

Oestreich KJ, Mohn SE, Weinmann AS. (2012). Molecular mechanisms that control the expression and activity of Bcl-6 in Th1 cells to regulate flexibility with a Tfh-like gene profile. Nat Immunol 13(4), 405-11.

Oestreich KJ, Weinmann AS. (2012). Encoding stability versus flexibility: Lessons learned from examining epigenetics in T helper cell differentiation. Curr Top Microbiol Immunol 356, 145-64.

Oestreich KJ, Weinmann AS. (2011). T-bet employs diverse regulatory mechanisms to repress transcription. Trends Immunol 33(2), 78-83.

Youngblood B, Oestreich KJ, Ha SJ, Duraiswamy J, Akondy RS, West EE, Wei Z, Lu P, Austin JW, Riley JL, Boss JM, Ahmed R. (2011). Chronic virus infection enforces demethylation of the locus that encodes PD-1 in antigen-specific CD8(+) T cells. Immunity 35(3), 400-12.

Kao C, Oestreich KJ, Paley MA, Crawford A, Angelosanto JM, Ali MA, Intlekofer AM, Boss JM, Reiner SL, Weinmann AS, Wherry EJ. (2011). Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection. Nat Immunol 12(7), 633-71.

Oestreich KJ, Huang AC, Weinmann AS. (2011). The lineage-defining factors T-bet and Bcl-6 collaborate to regulate Th1 gene expression patterns. J Exp Med 208(5), 1001-13.

Oestreich KJ, Yoon H, Ahmed R, Boss JM. (2008). Regulation of programmed death-1 by NFATc1 upon T cell activation. J Immunol 181(7), 4832-9.