Instrumentation

 

UHPLC Nexera X2 (Shimadzu)/SelexION/QTrap 5500 (Sciex)
A hybrid quadrupole ion trap system that typically operates as a triple quadrupole MS but can perform MS/MS/MS (MS3) experiments for enhanced identification and selectivity. The QTrap is also outfitted with the Sciex SelexION differential ion mobility spectrometry device, providing another dimension of separation that enables the Lipidyzer platform and other applications.

UHPLC 1260 & 1290/SFC/Q-TOF 6550 (Agilent)
A quadrupole time-of-flight ion funnel instrument for high-throughput metabolomics as well as discovery lipidomics. This system delivers high mass resolution (up to 40,000) and accurate mass capabilities (1-2 ppm) for identification, as well as best in-class sensitivity and four orders of dynamic range. Super-critical fluid chromatography (SFC) allows for separation of neutral and polar lipids in a single injection, and since SFC behaves like normal phase chromatography, it makes the analysis of very polar compounds that are difficult to retain in reversed phase separations more routine.

UHPLC 1290/Q-TOF 6550 (Agilent)
A quadrupole time-of-flight ion funnel instrument that delivers high mass resolution (up to 40,000) and accurate mass capabilities (1-2 ppm) for identification, as well as best in-class sensitivity and four orders of dynamic range. It is used primarily for untargeted metabolomics experiments and identification work.

UHPLC 1290/QqQ 6495 (Agilent)
A triple quadrupole with ion funnel optics provides the utmost sensitivity and dynamic range of our instruments allowing for outstanding quantitation. PDA detectors are in-line on all LCMS systems as well to collect UV-vis and MS spectra.