For a comprehensive list of publications, see Dr. Mitton-Fry’s CV.
Peer-reviewed Publications from Research at The Ohio State University (and in collaboration)
11. Mann, C. A.; Carvajal Moreno, J. J.; Lu, Y.; Dellos-Nolan, S.; Wozniak, D. J.; Yalowich, J. C.; Mitton-Fry, M. J. Novel Bacterial Topoisomerase Inhibitors: Unique Targeting Activities of Amide Enzyme-Binding Motifs for Tricyclic Analogs. Antimicrob. Agents Chemother. 2023, 67, e00482-23.
https://journals.asm.org/doi/10.1128/aac.00482-23
10. Phelps, H. A.; Kuhn, M.; Lu, Y.; Vibhute, S.; Watts, J. L.; Mitton-Fry, M. J. Antibacterial Activity of Novel Bacterial Topoisomerase Inhibitors against Key Veterinary Pathogens. Vet. Microbiol. 2023, 284, 109840.
https://www.sciencedirect.com/science/article/pii/S037811352300192X?via%3Dihub
9. Dauda, S. E.; Collins, J. A.; Byl, J. A. W.; Lu, Y.; Yalowich, J. C.; Mitton-Fry, M. J.; Osheroff, N. Actions of a Novel Bacterial Topoisomerase Inhibitor against Neisseria gonorrhoeae Gyrase and Topoisomerase IV: Enhancement of Double-Stranded DNA Breaks. Int. J. Molec. Sci. 2023, 24, 12107.
https://www.mdpi.com/1422-0067/24/15/12107
8. Chen, A.; Dellos-Nolan, S.; Lu, Y.; West, J. S.; Wozniak, D. J.; Mitton-Fry, M. J. Dioxane-Linked Novel Bacterial Topoisomerase Inhibitors Exhibit Bactericidal Activity Against Planktonic and Biofilm Staphylococcus aureus In Vitro. Microbiol. Spectr. 2022, 10, e02056-22.
https://journals.asm.org/doi/10.1128/spectrum.02056-22
7. Thirugnanasambantham, P.; Kovvali, S.; Cool, A.; Gao, Y.; Sabag-Daigle, A.; Boulanger, E. F.; Mitton-Fry, M.; Capua, A. D.; Behrman, E. J.; Wysocki, V. H.; Lindert, S.; Ahmer, B. M. M.; Gopalan, V. Serendipitous Discovery of a Competitive Inhibitor of FraB, a Salmonella Deglycase and Drug Target. Pathogens 2022, 11, 1102.
https://doi.org/10.3390/pathogens11101102
6. Lu, Y.; Mann, C. A.; Nolan, S.; Collins, J. A.; Parker, E.; Papa, J. L.; Vibhute, S.; Jahanbakhsh, S.; Thwaites, M.; Hufnagel, D.; Hazbón, M. H.; Moreno, J.; Stedman, T. T.; Wittum, T.; Wozniak, D. J.; Osheroff, N.; Yalowich, J. C.; Mitton-Fry, M. J. 1,3-Dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Expanding Structural Diversity and the Antibacterial Spectrum. ACS Med. Chem. Lett. 2022, 13, 955-963.
https://pubs.acs.org/doi/full/10.1021/acsmedchemlett.2c00111
5. Lu, Y. Vibhute, S.; Li, L.; Okumu, A.; Ratigan, S. C.; Nolan, S.; Papa, J. L.; Mann, C. A.; English, A.; Chen, A.; Seffernick, J. T.; Koci, B.; Duncan, L. R.; Roth, B.; Cummings, J. E.; Slayden, R. A.; Lindert, S.; McElroy, C. A.; Wozniak, D. J.; Yalowich, J.; Mitton-Fry, M. J. Optimization of TopoIV Potency, ADMET Properties, and hERG Inhibition of 5-Amino-1,3-dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Identification of a Lead with In Vivo Efficacy against MRSA. J. Med. Chem. 2021, 64, 15214-15249.
https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c01250
4. Lu, Y.; Papa, J. L.; Nolan, S.; English, A.; Seffernick, J. T.; Shkolnikov, N.; Powell, J.; Lindert, S.; Wozniak, D. J.; Yalowich, J.; Mitton-Fry, M. J. Dioxane-Linked Amide Derivatives as Novel Bacterial Topoisomerase Inhibitors against Gram-positive Staphylococcus aureus. ACS Med. Chem. Lett., 2020, 11, 2446-2454.
https://doi.org/10.1021/acsmedchemlett.0c00428
3. Okumu, A.; Lu, Y.; Dellos-Nolan, S.; Papa, J. L.; Koci, B.; Cockroft, N. T.; Gallucci, J.; Wozniak, D. J.; Yalowich, J. C.; Mitton-Fry, M. J. Novel Bacterial Topoisomerase Inhibitors Derived from Isomannide. Eur. J. Med. Chem., 2020, 199, 112324.
https://doi.org/10.1016/j.ejmech.2020.112324
2. Li, L.; Okumu, A. A.; Nolan, S.; English, A.; Vibhute, S.; Lu, Y.; Hervert-Thomas, K.; Seffernick, J. T.; Azap, L.; Cole, S. L.; Shinabarger, D.; Koeth, L. M.; Lindert, S.; Yalowich, J. C.; Wozniak, D. J.; Mitton-Fry, M. J. 1,3-Dioxane-Linked Bacterial Topoisomerase Inhibitors with Enhanced Antibacterial Activity and Reduced hERG Inhibition. ACS Infect Dis, 2019, 5, 1115-1128.
https://doi.org/10.1021/acsinfecdis.8b00375
1. Li, L.; Okumu, A.; Dellos-Nolan, S.; Li, Z.; Karmahapatra, S.; English, A.; Yalowich, J. C.; Wozniak, D. J.; Mitton-Fry, M. J. Synthesis and Anti-staphylococcal activity of Novel Bacterial Topoisomerase Inhibitors with a 5-amino-1,3-dioxane Linker Moiety. Bioorg. Med. Chem. Lett. 2018, 28, 2477-2480.
https://doi.org/10.1016/j.bmcl.2018.06.003
Review Articles/Chapters
2. Mohammed, S.; West, J. S.; Mitton-Fry, M. J. Aryl Methyl Ketones: Versatile Synthons in the Synthesis of Heterocyclic Compounds. SynOpen 2022, 6, 110-131.
https://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-1826-2852.pdf
1. Mitton-Fry, M. J. Novel Bacterial Type II Topoisomerase Inhibitors. Med. Chem. Rev. 2017, 52, 281-302.
https://www.acsmedchem.org/?nd=mcr5215