If you are interested in joining the lab, please contact Dr. Mathé directly at “ewy.mathe at osumc dot edu”.
I received my BA in Mathematics from Wichita State University in 2014 and my MS in Computer Science from Wichita State University in 2016, with a master’s thesis exploring the use of support vector machines to discriminate protein profiles of Down Syndrome and normal mice treated with memantine. I am currently pursuing a PhD in Computer Science with a Bioinformatics concentration, and am working jointly with Drs. Machiraju and Mathé. I am interested in applying machine learning to genomics research and am currently investigating the relationship between peak shape and transcription factor activity in ATAC-seq and DNASE-seq data.
I received my BS in Biomedical Engineering from Columbia University in 2006 and my MD from Indiana University School of Medicine in 2009. During my post-doctoral training under Drs Touloukian and Ivan at Indiana University I investigated the regulation and function of the novel mirco-RNA Mir210 which is a regulator of the cellular hypoxia response. As a bioinformatics researcher under Dr. Lang Li I analyzed transcriptomic changes in distant tissue metastases based on site and tissue of origin. I am currently a Research Specialist in the OSUMC Bioinformatics Shared Resource (BISR), jointly funded by the labs of Drs Peter Shields and Ewy Mathé. My current focus is the quantitative analysis targeted and un-targeted LC-MS metabolomic assays.
I received a BS in Biochemistry from Mount Saint Mary’s University, MD in 2000 and a PhD in Bioinformatics from George Mason University, VA in 2006. During my post-doctoral training with Dr. Curtis Harris at the National Cancer Institute, I discovered putative esophageal and lung cancer biomarkers using miRNA microarrays and metabolomics. As a Bioinformatics Staff Scientist in Dr. Rafael Casellas’ laboratory (NIAMS/NIH), I aimed to better understand modalities of transcriptional regulation in B lymphocytes, using state-of-the-art next-generation sequencing techniques. In the Fall of 2015, I joined the Biomedical Informatics to pursue research in developing algorithms for biomarker and therapeutic target discovery in cancer.
I earned my undergraduate degree in 2015 from SUNY Geneseo, getting a B.S. in biochemistry and a minor in biomathematics. During my time at Geneseo, I had the opportunity to study sex-based differences in monocarboxylate-transporter-1 gene expression during a summer research project in the lab of Dr. Marilyn Morris in the Pharmaceutical Science department at the University at Buffalo. After graduating, I spent a year in the lab of Dr. Michael Ombrello at the National Institute of Arthritis and Musculoskeletal and Skin Diseases in Bethesda, Maryland, where we used deep sequencing and bioinformatics pipelines to identify rare genetic variants that are associated with systemic juvenile idiopathic arthritis. My research experiences at the NIH and UB helped me develop an interest in computational biology, which lead me to the lab of Dr. Ewy Mathé at OSU. I am currently working on developing tools for integrating metabolomic data and transcriptomic data on a pathway level, using hybrid integration approaches such as fuzzy logic modeling and linear modeling, as opposed to purely data-driven approaches such as Bayesian networks, or knowledge-driven approaches such as Boolean networks or Ordinary Differential Equations. I am interested in applying these techniques to identify novel, context-specific interactions between genes and metabolites, as well as to identify dysregulated biochemical pathways in sarcoma tumors.
I am currently a junior student on a pre-medicine track pursuing a major in Biology and minors in Computer Science and Chemistry at Indiana State University located in Terre Haute, IN. I am part of a research program called Big Data for Indiana State University (BD4ISU) that allows me to spend a 10-week summer internship in the Department of Biology at Indiana State University and in the Department of Biomedical Informatics of the Ohio State University consecutively. In summer 2018, I worked in Dr. Ahmad’s laboratory and we aimed to identify the enhancer of the branchless gene in Drosophila. This gene is particularly interesting because it is regulated in a sex-specific, tissue-specific, and segment-specific manner in fruit flies. Starting in the summer 2019, I have been working with Dr. Mathé’s laboratory on a murine project regarding the relationship between early days diet type and colonic microbiota in mice. I am interested in applying biomedical big data manipulation methods in order to gain more insight into the complexity of cancer.
I earned my bachelor’s degree from Central Michigan University in 2016 with a BS in Biomedical Sciences. During my time as an undergrad I worked with Dr. Stephen Juris focusing on the bacterial pathogen Vibrio cholerae by attempting to identify mutated Actin Cross-linking Domain (ACD) plasmid sequences that allow Saccharomyces cerevisiae to survive Wild-Type ACD expression. I also completed my Master of Science degree at CMU. My graduate research with Dr. Stephen Juris focused on the biochemical interactions of the VcRTXA toxin produced by Vibrio cholerae specifically by attempting to identify the Actin-ACD binding sites of VcRTXA in vitro. This work will be used in the future for drug-discovery purposes with the goal of creating a new cost-efficient drug to be used to fight Cholera in developing countries. I joined the Mathe lab to learn about bioinformatics with the hopes of merging my love of wet-lab techniques with the analytical power of computational biology to solve complex biological problems in the future.
I received my BS in Cell and Molecular Biology from Binghamton University in 2010. I received my MA in Biology with a concentration in Biotechnology from Hunter College in 2013. From 2013-2014 I worked at The Rockefeller University where I was studying the effects of prenatal alcohol exposure. I have been in the Molecular, Cellular and Developmental Biology program at OSU since Fall 2014. I am now jointly working in the labs of Drs. Peter Shields and Ewy Mathe, studying microbiome of smokers, e-cig users and non-smokers.
Manjukumar Patil, MS, Software Development Engineer, Amazon
Jalal Siddiqui, PhD, Post-doctoral researcher at the Comprehensive Cancer Center at The Ohio State University Wexner Medical Center
Zach Weber, MS Student in BMI at OSU
Bofei Zhang, Graduate student in Data Science at New York University
Kartik Lovekar, Graduate student in Computer Science at OSU
Mingrui Liu, Undergraduate student, Data analytics
Elizabeth Baskin, BS, fellowship at Chase.
Senyang Hu, MS – transitioning to industry position.
Rick Farouni, PhD, Post-doctoral fellow at McGill University-Génome Québec Innovation Centre. http://rfarouni.github.io/
Diana Guttierez-Cruz, MS – transitioning to obtaining a PhD degree at OSU.