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2024

• Synergistic Role of NK Cells and Monocytes in Promoting Atherogenesis in Severe COVID-19 Patients. Gunasena M, Alles M, Wijewantha Y, Mulhern W, Bowman E, Gabriel J, Kettelhut A, Kumar A, Weragalaarachchi K, Kasturiratna D, Horowitz JC, Scrape S, Pannu SR, Liu SL, Vilgelm A, Wijeratne S, Bednash JS, Demberg T, Funderburg NT, Liyanage NPM. Arterioscler Thromb Vasc Biol.  2024 Oct;44(10): e243-e261. doi: 10.1161/ATVBAHA.124.321085.                                                                                                                     This article was featured in the editorial of the 2024 October issue of  ATVB.

• BCG immunization-induced KLRG1+ NK cells show memory-like responses to mycobacterial and HIV antigens. Gunasena M, Alles M, Demberg T, Mulhern W, Liyanage NPM. Cell Immunol. 2024 Sep 2;403-404:104865. doi:10.1016/j.cellimm. 2024. 104865. PMID: 39226746.
• Unveiling the Immune Dynamics of Neisseria Persistent Oral Colonization. Alles M, Gunasena M, Zia T, D’Mello A, Bhattarai S, Mulhern W,Terry L, Scherger T, Wijeratne S, Singh S, Wijeratne A, Kasturiratna D, Tettelin H, Weyand N, Liyanage NPM. Infect Immun. 2024 May 30:e0004824. doi: 10.1128/iai.00048-24. PMID: 38814083.

2023

• Innate adaptive immune cell dynamics in tonsillar tissues during chronic SIV infection.Shukla RK, Gunasena M, Reinhold-Larsson N, Duncan M, Hatharasinghe A, Cray S, Weragalaarachchi K, Kasturiratna D, Demberg T, Liyanage NPM.  Front Immunol. 2023;14:1201677. doi: 10.3389/fimmu.2023.1201677. eCollection 2023. PubMed PMID: 37671159.
• SARS-CoV-2 infection of companion animals in Egypt and its risk of spillover. Mervat E Hamdy, Ayman H El-Deeb, Naglaa M Hagag, Momtaz A Shahein , Namal P.M Liyanage, Mohamed Shalaan, Hussein A Hussein. SARS-CoV-2 infection of companion animals in Egypt and its risk of spillover. Vet Med Sci. 2023 Jan;9(1):13-24. doi:10.1002/vms3.1029. PMID: 36516308.

2022

• Evaluation of early innate and adaptive immune responses to the TB vaccine Mycobacterium bovis BCG and vaccine candidate BCGΔBCG1419c. Gunasena M, Shukla RK, Yao N, Rosas Mejia O, Powell MD, Oestreich KJ, Aceves-Sánchez MJ, Flores-Valdez MA, Liyanage NPM, Robinson RT. Sci Rep. (2022) Jul 20;12(1):12377. doi: 10.1038/s41598-022-14935-y.PMID: 35858977. * Co-corresponding authors.
• Estrogen May Enhance Toll-like Receptor 4-Induced Inflammatory Pathways in People with HIV : Implications for Transgender Women with HIV on Hormone Therapy. Aaren Kettelhut, Emily Bowman, Janelle Gabrielle, Brittany Hand, Namal P.M. Liyanage, Manjusha Kulkarni, Frances Avila-Soto, Jordan E. Lake, Nicholas T. Funderburg. (2022) June 03 .Front Immunol. 10.3389/ fimmu. 2022. 879600.
• Comparison of CD3e antibody and CD3e-sZAP immunotoxin treatment in mice identifies sZAP as the main driver of vascular leakage. Shihyoung Kim, Rajni Kant Shukla, Eunsoo Kim, Sophie G Cressman, Hannah Yu, Alice Baek, Hye Won Choi, Alan Kim, Amit Sharma, Zhirui Wang, Christene A. Huang, John C Reneau, Prosper N. Boyaka, Namal P. M. Liyanage, and Sanggu Kim. Comparison Biomedicines (2022), 10(6):1221 DOI: 10.3390/biomedicines10061221
• SARS-CoV-2 Survivors with Chronic Health Conditions: A Pilot Study on “COVID Long-Haulers” May 2022Journal of Diagnostic Medical Sonography. Kevin D Evans, Isaiah W. Bloom, Nicole Stigall-Weikle, Tara Weaver, Munaju Gunasena, Nicholas T Funderburg, Namal P.M. Liyanage. (2022) Journal of Diagnostic Medical Sonography. May 2022. DOI: 10.1177/87564793221100259

• Tissue-localized immune responses in people with cystic fibrosis and respiratory nontuberculous mycobacteria infection.Hayes D Jr, Shukla RK, Cheng Y, Gecili E, Merling MR, Szczesniak RD, Ziady AG, Woods JC, Hall-Stoodley L, Liyanage NP*, Robinson RT*. JCI Insight. 2022 May 10:e157865. doi: 10.1172/jci.insight.157865. Online ahead of print.PMID: 35536650 . * Co-corresponding authors.

•  Treatment with soluble CD24 attenuates COVID-19-associated systemic immunopathology.
  Song NJ, Allen C, Vilgelm AE, Riesenberg BP, Weller KP, Reynolds K, Chakravarthy KB, Kumar A, Khatiwada A, Sun Z, Ma A, Chang Y, Yusuf M, Li A, Zeng C, Evans JP, Bucci D, Gunasena M, Xu M, Liyanage NPM, Bolyard C, Velegraki M, Liu SL, Ma Q, Devenport M, Liu Y, Zheng P, Malvestutto CD, Chung D, Li Z.J Hematol Oncol. 2022 Jan 10;15(1):5. doi: 10.1186/s13045-021-01222-y.PMID: 35012610.

2021

• Inhibition of elastase enhances the adjuvanticity of alum and promotes anti-SARS-CoV-2 systemic and mucosal immunity. Eunsoo Kim , Zayed Attia, Rachel M Woodfint , Cong Zeng, Sun Hee Kim, Haley E Steiner, Rajni Kant Shukla, Namal P. M. Liyanage, Shristi Ghimire, Jianrong Li, Gourapura J Renukaradhya , Abhay R Satoskar, Amal O Amer, Shan-Lu Liu, Estelle Cormet-Boyaka , Prosper N Boyaka. (2021) Proc Natl Acad Sci U S A. 2021 Aug 24;118(34):e2102435118. doi: 10.1073/pnas.2102435118.
• Anti-V2 antibodies virus vulnerability revealed by envelope V1 deletion in HIV vaccine candidates. Isabela Silva de Castro, Giacomo Gorini, Rosemarie Mason, Jason Gorman, Massimiliano Bissa, Mohammad A. Rahman, Anush Arakelyan, Irene Kalisz, Stephen Whitney, Manuel Becerra-Flores, Eric Ni, Kristina Peachman, Hung V. Trinh, Michael Read, Mei-Hue Liu, Donald Van Ryk, Dominic Paquin-Proulx, Zhanna Shubin, Marina Tuyishime, Jennifer Peele, Mohammed S. Ahmadi, Raffaello Verardi, Juliane Hill, Margaret Beddall, Richard Nguyen, James D. Stamos, Dai Fujikawa, Susie Min, Luca Schifanella, Monica Vaccari, Veronica Galli, Melvin N. Doster, Namal P.M. Liyanage, Sarkis Sarkis, Francesca Caccuri, Celia LaBranche, David C. Montefiori, Georgia D. Tomaras, Xiaoying Shen, Margherita Rosati, Barbara K. Felber, George N. Pavlakis, David J. Venzon, William Magnanelli, Matthew Breed, Josh Kramer, Brandon F. Keele, Michael A. Eller, Claudia Cicala, James Arthos, Guido Ferrari, Leonid Margolis, Marjorie Robert-Guroff, Peter D. Kwong, Mario Roederer, Mangala Rao, Timothy J. Cardozo, Genoveffa Franchini.  (2021)  iScience . (DOI::doi.org/10.1016/j.isci.2021.102047)

2020

• Innate Immune Responses to Highly Pathogenic Coronaviruses and Other Significant Respiratory Viral Infections. Ahmed-Hassan H, Sisson B, Shukla RK, Wijewantha Y, Funderburg NT, Li Z, Hayes D Jr, Demberg T and Liyanage NPM (2020)  Front. Immunol. 11:1979. doi: 10.3389/fimmu.2020.01979
• Engagement of monocytes, NK cells, and CD4+ Th1 cells by ALVAC-SIV vaccination results in a decreased risk of SIVmac251 vaginal acquisition. Gorini G, Fourati S, Vaccari M, Rahman MA, Gordon SN, Brown DR, Law L, Chang J, Green R, Barrenäs F, Liyanage NPM, Doster MN, Schifanella L, Bissa M, Silva de Castro I, Washington-Parks R, Galli V, Fuller DH, Santra S, Agy M, Pal R, Palermo RE, Tomaras GD, Shen X, LaBranche CC, Montefiori DC, Venzon DJ, Trinh HV, Rao M, Gale M Jr, Sekaly RP, Franchini G. PLoS Pathog. 2020 Mar;16(3):e1008377. doi: 10.1371/journal.ppat.1008377. eCollection 2020 Mar. PubMed PMID: 32163525; PubMed Central PMCID: PMC7093029.

• Expression of CD40L by the ALVAC-Simian Immunodeficiency Virus Vector Abrogates T Cell Responses in Macaques.Silva de Castro I, Gordon SN, Liu J, Bissa M, McKinnon K, Trinh HV, Doster MN, Schifanella L, Liyanage NP, Cao J, Cheng O, Foulds K, Roederer M, Koup RA, Shen X, Tomaras GD, Venzon DJ, Forthal DN, Fouts T, Montefiori DC, Tartaglia J, Rao M, Ostrowski M, Franchini G, Vaccari M.  J Virol. 2020 Feb 28;94(6). doi: 10.1128/JVI.01933-19. Print 2020 Feb 28. PubMed PMID: 31896599.
• Lung T-Cell Profile Alterations are Associated with Bronchiolitis Obliterans Syndrome in Cystic Fibrosis Lung Transplant Recipients Hayes D Jr, Harhay MO, Nicol KK, Liyanage NPM, Keller BC, Robinson RT.  Lung. 2019 Dec 5;. doi: 10.1007/s00408-019-00298-1. [Epub ahead of print] PubMed PMID: 31807920.

2019

• ALVAC-HIV B/C candidate HIV vaccine efficacy dependent on neutralization profile of challenge virus and adjuvant dose and type. Schifanella L, Barnett SW, Bissa M, Galli V, Doster MN, Vaccari M, Tomaras GD, Shen X, Phogat S, Pal R, Montefiori DC, LaBranche CC, Rao M, Trinh HV, Washington-Parks R, Liyanage NPM, Brown DR, Liang F, Loré K, Venzon DJ, Magnanelli W, Metrinko M, Kramer J, Breed M, Alter G, Ruprecht RM, Franchini G. PLoS Pathog. 2019 Dec;15(12):e1008121. doi: 10.1371/journal.ppat.1008121. eCollection 2019 Dec. PubMed PMID: 31794588.

• TH cells’ capacity for TH1 and TH17 differentiation is attenuated in children with nontuberculous mycobacteria infection. Claeys TA, Rosas Mejia O, Marshall S, Jarzembowski JA, Hayes D Jr, Hull NM, Liyanage NPM, Chun RH, Sulman CG, Huppler AR, Robinson RT. J Infect Dis. 2019 Jul 23;. doi: 10.1093/infdis/jiz371. [Epub ahead of print] PubMed PMID: 31332447.

2018

• HIV vaccine candidate activation of hypoxia and the inflammasome in CD14⁺ monocytes is associated with a decreased risk of SIV_mac251 acquisition. Vaccari M, Fourati S, Gordon SN, Brown DR, Bissa M, Schifanella L, Silva de Castro I, Doster MN, Galli V, Omsland M, Fujikawa D, Gorini G, Liyanage NPM, Trinh HV, McKinnon KM, Foulds KE, Keele BF, Roederer M, Koup RA, Shen X, Tomaras GD, Wong MP, Munoz KJ, Gach JS, Forthal DN, Montefiori DC, Venzon DJ, Felber BK, Rosati M, Pavlakis GN, Rao M, Sekaly RP, Franchini G. Nat Med. 2018 Jun;24(6):847-856. doi: 10.1038/s41591-018-0025-7. Epub 2018 May 21. PubMed PMID: 29785023; PubMed Central PMCID: PMC5992093.

2017

• Stool antigen immunodetection for diagnosis of Giardia duodenalis infection in human subjects with HIV and cancer. Nooshadokht M, Kalantari-Khandani B, Sharifi I, Kamyabi H, Liyanage NPM, Lagenaur LA, Kagnoff MF, Singer SM, Babaei Z, Solaymani-Mohammadi S. J Microbiol Methods. 2017 Oct;141:35-41. doi: 10.1016/j.mimet.2017.07.004. Epub 2017 Jul 14. PubMed PMID: 28716658; PubMed Central PMCID: PMC6261429.

Prior to 2017

• Adjuvant-dependent innate and adaptive immune signatures of risk of SIVmac251 acquisition. Vaccari M*, Gordon SN*, Fourati S*, Schifanella L*, Liyanage NP*, Cameron M, Keele BF, Shen X, Tomaras GD, Billings E, Rao M, Chung AW, Dowell KG, Bailey-Kellogg C, Brown EP, Ackerman ME, Vargas-Inchaustegui DA, Whitney S, Doster MN, Binello N, Pegu P, Montefiori DC, Foulds K, Quinn DS, Donaldson M, Liang F, Loré K, Roederer M, Koup RA, McDermott A, Ma ZM, Miller CJ, Phan TB, Forthal DN, Blackburn M, Caccuri F, Bissa M, Ferrari G, Kalyanaraman V, Ferrari MG, Thompson D, Robert-Guroff M, Ratto-Kim S, Kim JH, Michael NL, Phogat S, Barnett SW, Tartaglia J, Venzon D, Stablein DM, Alter G, Sekaly RP, Franchini G. Nat Med. 2016 Oct 6;22(10):1192. doi: 10.1038/nm1016-1192a. PubMed PMID: 27711066. ( * equal contributions)

• Boosting of ALVAC-SIV Vaccine-Primed Macaques with the CD4-SIVgp120 Fusion Protein Elicits Antibodies to V2 Associated with a Decreased Risk of SIVmac251 Acquisition.Gordon SN, Liyanage NP, Doster MN, Vaccari M, Vargas-Inchaustegui DA, Pegu P, Schifanella L, Shen X, Tomaras GD, Rao M, Billings EA, Schwartz J, Prado I, Bobb K, Zhang W, Montefiori DC, Foulds KE, Ferrari G, Robert-Guroff M, Roederer M, Phan TB, Forthal DN, Stablein DM, Phogat S, Venzon DJ, Fouts T, Franchini G.  J Immunol. 2016 Oct 1;197(7):2726-37. doi: 10.4049/jimmunol.1600674. Epub 2016 Sep 2. PubMed PMID: 27591322; PubMed Central PMCID: PMC5026031.
• Glucocorticoid treatment at moderate doses of SIVmac251-infected rhesus macaques decreases the frequency of circulating CD14+CD16++ monocytes but does not alter the tissue virus reservoir. Moniuszko M*, Liyanage NP*, Doster MN, Parks RW, Grubczak K, Lipinska D, McKinnon K, Brown C, Hirsch V, Vaccari M, Gordon S, Pegu P, Fenizia C, Flisiak R, Grzeszczuk A, Dabrowska M, Robert-Guroff M, Silvestri G, Stevenson M, McCune J, Franchini G. AIDS Res Hum Retroviruses. 2015 Jan;31(1):115-26. doi: 10.1089/AID.2013.0220. PubMed PMID: 24432835; PubMed Central PMCID: PMC4287193. (*equal contributions)
• Comparative analysis of SIV-specific cellular immune responses induced by different vaccine platforms in rhesus macaques.Valentin A, McKinnon K, Li J, Rosati M, Kulkarni V, Pilkington GR, Bear J, Alicea C, Vargas-Inchaustegui DA, Jean Patterson L, Pegu P, Liyanage NP, Gordon SN, Vaccari M, Wang Y, Hogg AE, Frey B, Sui Y, Reed SG, Sardesai NY, Berzofsky JA, Franchini G, Robert-Guroff M, Felber BK, Pavlakis GN. Clin Immunol. 2014 Nov;155(1):91-107. doi: 10.1016/j.clim.2014.09.005. Epub 2014 Sep 16. PubMed PMID: 25229164; PubMed Central PMCID: PMC4252823.
• Humoral immunity induced by mucosal and/or systemic SIV-specific vaccine platforms suggests novel combinatorial approaches for enhancing responses.  Vargas-Inchaustegui DA, Tuero I, Mohanram V, Musich T, Pegu P, Valentin A, Sui Y, Rosati M, Bear J, Venzon DJ, Kulkarni V, Alicea C, Pilkington GR, Liyanage NP, Demberg T, Gordon SN, Wang Y, Hogg AE, Frey B, Patterson LJ, DiPasquale J, Montefiori DC, Sardesai NY, Reed SG, Berzofsky JA, Franchini G, Felber BK, Pavlakis GN, Robert-Guroff M.  Clin Immunol. 2014 Aug;153(2):308-22. doi: 10.1016/j.clim.2014.05.008. Epub 2014 Jun 4. PubMed PMID: 24907411; PubMed Central PMCID: PMC4102324.

• Antiretroviral therapy partly reverses the systemic and mucosal distribution of NK cell subsets that is altered by SIVmac₂₅₁ infection of macaques. Liyanage NP, Gordon SN, Doster MN, Pegu P, Vaccari M, Shukur N, Schifanella L, Pise-Masison CA, Lipinska D, Grubczak K, Moniuszko M, Franchini G. Virology. 2014 Feb;450-451:359-68. doi: 10.1016/j.virol.2013.12.003. Epub 2014 Jan 21. PubMed PMID: 24503100; PubMed Central PMCID: PMC5008240.

• Contribution of Helicobacter hepaticus cytolethal distending toxin subunits to human epithelial cell cycle arrest and apoptotic death in vitro.  Liyanage NP, Dassanayake RP, Kuszynski CA, Duhamel GE.  Helicobacter. 2013 Dec;18(6):433-43. doi: 10.1111/hel.12084. Epub 2013 Jul 29. PubMed PMID: 23895367; PubMed Central PMCID: PMC3808484.
• Glucocorticoids upregulate decreased IL-7 receptor expression in asthmatic patients and simian immunodeficiency virus-infected non-human primates.Moniuszko M, Lipinska D, Jeznach M, Kowal K, Grubczak K, Rusak M, McKinnon K, Vaccari M, Liyanage NP, Fenizia C, Wawrusiewicz-Kurylonek N, Dabrowska M, Jablonska E, Kretowski A, Gorska M, Bodzenta-Lukaszyk A. J Biol Regul Homeost Agents. 2013 Apr-Jun;27(2):427-42. PubMed PMID: 23830393.

• Helicobacter hepaticus cytolethal distending toxin causes cell death in intestinal epithelial cells via mitochondrial apoptotic pathway.Liyanage NP, Manthey KC, Dassanayake RP, Kuszynski CA, Oakley GG, Duhamel GE.  Helicobacter. 2010 Apr;15(2):98-107. doi: 10.1111/j.1523-5378.2010.00749.x. PubMed PMID: 20402812.

• Regulation of the bioavailability of thioredoxin in the lens by a specific thioredoxin-binding protein (TBP-2). Liyanage NP, Fernando MR, Lou MF. Exp Eye Res. 2007 Aug;85(2):270-9. doi: 10.1016/j.exer.2007.05.001. Epub 2007 May 21. PubMed PMID: 17603038; PubMed Central PMCID: PMC1994116.

• Seroprevalence of varicella zoster virus infections in Colombo district, Sri Lanka.Liyanage NP, Fernando S, Malavige GN, Mallikahewa R, Sivayogan S, Jiffry MT, Vitarana T.  Indian J Med Sci. 2007 Mar;61(3):128-34. PubMed PMID: 17337813.

• Helicobacter pylori serology in two MOH areas of the Western province of Sri Lanka. Fernando N, Weeraseker D, Fernando S, Liyanage N, Holton J. Ceylon Journal of Medical Science. 2003; 46(2):35-43. doi: 10.4038/cjms.v46i2.4827.