Sir, We’ve Secured Your Pancreas . . . From a Pig

by Jennie Pugliese, Sustainable Plant Systems major

If you were in need of an organ transplant, would you accept one grown inside a pig? This may seem absurd now but the US may not be far off from this reality. One of Japan’s top scientists, Professor Hiromitsu Nakauchi, has spent years perfecting the art of adjoining two genetically different creatures, cleverly called chimeras, and is now on his way to California.

This may seem like a bit of science fiction, however Professor Nakauchi has successfully created a mouse with a rat pancreas as recently as 2010. His method involves inserting stem cells into a genetically modified embryo then implanting this into a surrogate, such as a pig. The embryo thus develops with the body of the embryo donor and the organs of the stem cell donor.

Obviously this raises many ethical questions and concerns. While a never-ending supply of human organs could be beneficial to those in need, are we willing to accept the image of an industry full of pigs containing human organs like something out a George Orwell novel? If there is such resistance to genetically engineered foods how could our society ever accept the idea of genetically engineered organs? This is surely not a debate or question to be settled anytime soon.

Read More > Animal-grown transplant organs (the-scientist.com)

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This blog post was an assignment for  Societal Issues: Pesticides, Alternatives and the Environment (PLNTPTH 4597) and is a repost from August 14, 2014. The views expressed are those of the author and do not necessarily reflect the views of the class, Department of Plant Pathology or the instructor.

Plants Can Pack A Punch

treeby David Dietsch, Agricultural Systems Management major

Most of us see plants as defenseless organisms, simply growing on this planet to enjoy the sunshine and provide us with quality air, food, and other products. These seemingly quiet things are on a mission however.

Plants aim to reproduce and populate the earth much like humans, and many plant species have developed their own ways to ensure they will live on. Facing a plethora of predators, plants rely on several different combinations of chemical and physical defense mechanisms to protect themselves against animals, insects, and pathogens.

Some notable defenses include growing a dense covering of hair, emitting heart attack inducing toxins, and even attracting predators of predators. That’s right, when being eaten some plants will release a chemical that attracts wasps. Wasps will inject their eggs into the plant predator, killing the pest and bringing birth to a new generation of wasps.

It is amazing what some plants are capable of, even the ones right outside our own doors. The next time you see something growing in the woods or in a field, keep in mind that it may not be as harmless as it looks!

To learn more about the defenses mentioned here and many more, visit:
> How Plants Defend Themselves From Predators
> Self Defense by Plants (CA Ryan and A Jagendorf, 1995, PNAS)

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This blog post was an assignment for  Societal Issues: Pesticides, Alternatives and the Environment (PLNTPTH 4597). The views expressed are those of the author and do not necessarily reflect the views of the class, Department of Plant Pathology or the instructor.

Just Needed: 32,000 Years of Dust Blown Off and Some Elbow Grease

by Anthony Carelly, Sustainable Plant Systems major

A radiocarbon confirmed 32,000 year old plant was grown setting a new record. Hidden by a squirrel during the Ice Age in Siberia, a Russian team has successfully germinated and produced a Silene stenophylla. The seeds were encased in layers of animal bones 124 feet below the ice. This is absolutely fascinating for a multitude of reasons: that it was possible in the first place given our technological advances; the environmental condition that preserved the seed; the illustration of the potential for storing seeds for tens of thousands of years. I for one would love to see a biodome set up that was dedicated to ancient plants such as this one, and maybe a cloned Velociraptor or two. Of the few seeds the scientist planted, each had similar structures but bloomed differently!

Read more
32,000 Year-Old Plant Brought Back To Life – Oldest Yet
(R. Kaufman, National Geographic News, Feb. 21, 2012)

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This blog post was an assignment for  Societal Issues: Pesticides, Alternatives and the Environment (PLNTPTH 4597). The views expressed are those of the author and do not necessarily reflect the views of the class, Department of Plant Pathology or the instructor.

Tobacco: cure for cancer?

Nicotiana alata

Nicotiana alata1By Carl E Lewis (Wikipedia)

by Zachary Foust, Plant Health Management major

Tobacco has an interesting history; from Native American rituals to worldwide use, this once crucial cash crop is typically only associated with cancer nowadays. However, a new study completed at La Trobe University (Australia) has found a cancer-fighting protein in the flowers of the ornamental tobacco plant, Nicotiana alata.

The irony is almost painful.

Don’t run out and grab a pack of 100s yet; the cultivar used for testing is not the kind used to make cigarette tobacco.

The protein, NaD1, is found in the plant’s flowers and it occurs naturally to fight off fungi and bacteria. NaD1 essentially “grabs” a cancerous cell and tears it open. The contents of the cell are released and the cell is destroyed.

Preliminary testing looks promising as it may finally lead to a discriminant form of cancer treatment.

I welcome this finding and hope it leads to a cure for cancer. Not only would radiation be completely unnecessary, the cancer-fighting molecule is derived from a plant.

This discovery should encourage all universities to begin preliminary testing with NaD1. The more people working towards a viable treatment, the faster one may be found.

One concern that should be noted is that the molecule is only produced when the plant is flowering. NaD1 may potentially have a short half-life, especially inside of the human body. This may require repeat treatments and possibly lead to increased rates of cancer returning.

For now, this protein shows great promise and may one day lead to a cure for cancer. Only time will tell.

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This blog post was an assignment for  Societal Issues: Pesticides, Alternatives and the Environment (PLNTPTH 4597). The views expressed are those of the author and do not necessarily reflect the views of the class, Department of Plant Pathology or the instructor.

You don’t realize how important something is until it’s gone

white nose fungus on bats

Photo: U.S. Fish and Wildlife Service

Nearly 7 million bats – and counting – have succumbed to a fungus that has been spreading throughout the eastern U.S.

White nose syndrome, named for the visible white fungal growth on the noses of affected bats, has spread throughout the eastern U.S., including Ohio.  First documented in eastern New York in 2007, the fungus appears to infect hibernating bats, with a mortality rates 90 to 100%.

The fungus is believed to be an introduced species, in part because North American bat populations seem to have very low levels of immunity, or genetic resistance.  In contrast, European bat species and the white nose fungus appear to have evolved over time to co-exist.

In addition to tremendous ecological ramifications,  impacts include economic losses (estimated losses in agriculture: billions), public health (bats eat mosquitoes and other insects that may vector disease), and loss of tourism (cave tours and hiking contribute millions of dollars into area economies > here’s an example).

Working with the unknown – even in this day and age – presents several challenges.  Recent research at the University of Akron is helping put together some of the puzzle pieces.  Hannah Reynolds, lead author on this study featured in Science Daily, is currently a postdoctoral researcher in the Department of Plant Pathology.
> Read more

Learn more about bats and white nose syndrome > whitenosesyndrome.org

Bioterrorism Course Offers Special Opportunity

Bacillus anthracis

Upper right: Mike Boehm. Bacillus anthracis CDC Public Health Image Library No. 10123

Bioterrorism: An Overview is a course offered by the Department of Plant Pathology this spring (PLNTPTH 4550/INTSTDS 4550).

At first glance, you might not connect Plant Pathology to bioterrorism, but we do work with pathogens, and pathogens of humans, animals or plants are very serious concerns to food security and food safety.

The course is taught by Mike Boehm, Vice Provost for Strategic Planning, Special Assistant to the President, Professor of Plant Pathology, and former Naval Reserve Lieutenant Commander.  After 9/11, while on the faculty of the Department of Plant Pathology, Dr. Boehm was placed on active military duty, where much of his work centered on bioterrorism agents such as anthrax.

He brings this first-hand experience to the classroom, along with his passion for teaching.  Taking a class from Dr. Boehm is on the list of special opportunities for students at Ohio State.

PLNTPTH 4550 (3 credits) > Read more
SPRING 2014, Class no. 14127
MoWe 5:30PM – 8:00PM  Denney Hall 0253
First 7-weeks of the semester