Cold is painful!

“Some people experience cold not only as feeling cold, but actually as a painful sensation.”  I nearly froze when I read that opening sentence from the Science Daily news, “Cold-induced pain linked to the garlic, mustard receptor.”

Yes, I thought.  Cold is painful.  It’s awful.  Some people always seem to “feel” cold.  Now, here’s some information on the underlying genetic basis.

The Science Daily reports that researchers established that mustard and garlic receptors are also sensitive to cold, as well as “chemical substances that irritate the airways.”  (I don’t like strong smells, either!)

This research has important medical applications, too, for patients suffering from chronic pain, certain diseases, or side-effects from chemotherapy or other treatments.

The wind chill is 8ºF right now, and wrapped in a blanket as I write this.  But I’m not complaining.  Maybe resiliency is part of my genetics!

Journal reference

L. Moparthi, S. Survery, M. Kreir, C. Simonsen, P. Kjellbom, E. D. Hogestatt, U. Johanson, P. M. Zygmunt. Human TRPA1 is intrinsically cold- and chemosensitive with and without its N-terminal ankyrin repeat domain. Proceedings of the National Academy of Sciences, 2014; DOI: 10.1073/pnas.1412689111

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