Drug-Drug Interaction Pharmaco-informatics and Pharmaco-epidemiology

Publication

• Duke JD, Han X, Wang Z, Subhadarshini A, Karnik SD, Li X, Hall SD, Jin Y, Callaghan JT, Overhage MJ, Flockhart DA, Strother RM, Quinney SK, Li L. Literature based drug interaction prediction with clinical assessment using electronic medical records: novel myopathy associated drug interactions. PLoS Comput Biol. 2012;8(8):e1002614. doi: 10.1371/journal.pcbi.1002614. Epub 2012 Aug 9. PMID: 22912565; PMCID: PMC3415435.
• Han X, Quinney SK, Wang Z, Zhang P, Duke J, Desta Z, Elmendorf JS, Flockhart DA, Li L. Identification and Mechanistic Investigation of Drug-Drug Interactions Associated With Myopathy: A Translational Approach. Clin Pharmacol Ther. 2015 Sep;98(3):321-7. doi: 10.1002/cpt.150. PMID: 25975815; PMCID: PMC4664558.
• Han X, Chiang C, Leonard CE, Bilker WB, Brensinger CM, Li L, Hennessy S. Biomedical Informatics Approaches to Identifying Drug-Drug Interactions: Application to Insulin Secretagogues. Epidemiology. 2017 May;28(3):459-468. doi: 10.1097/EDE.0000000000000638. PMID: 28169935; PMCID: PMC5378621.
• Schelleman H, Han X, Brensinger CM, Quinney SK, Bilker WB, Flockhart DA, Li L, Hennessy S. Pharmacoepidemiologic and in vitro evaluation of potential drug-drug interactions of sulfonylureas with fibrates and statins. Br J Clin Pharmacol. 2014 Sep;78(3):639-48. doi: 10.1111/bcp.12353. PMID: 24548191; PMCID: PMC4243914.
• Wang L, Shendre A, Chiang CW, Cao W, Ning X, Zhang P, Zhang P, Li L. A pharmacovigilance study of pharmacokinetic drug interactions using a translational informatics discovery approach. Br J Clin Pharmacol. 2022 Feb;88(4):1471-1481. doi: 10.1111/bcp.14762. Epub 2021 Feb 23. PMID: 33543792.
• Zhu Y, Chiang CW, Wang L, Brock G, Milks MW, Cao W, Zhang P, Zeng D, Donneyong M, Li L. A multistate transition model for statin-induced myopathy and statin discontinuation. CPT Pharmacometrics Syst Pharmacol. 2021 Oct;10(10):1236-1244. doi: 10.1002/psp4.12691. Epub 2021 Sep 25. PMID: 34562311; PMCID: PMC8520747.
• Shi Y, Chiang CW, Unroe KT, Oyarzun-Gonzalez X, Sun A, Yang Y, Hunold KM, Caterino J, Li L, Donneyong M, Zhang P. Application of an Innovative Data Mining Approach Towards Safe Polypharmacy Practice in Older Adults. Drug Saf. 2024 Jan;47(1):93-102. doi: 10.1007/s40264-023-01370-9. Epub 2023 Nov 7. PMID: 37935996; PMCID: PMC11256269.
• Donneyong MM, Zhu Y, Zhang P, Li Y, Hunold KM, Chiang C, Unroe K, Caterino JM, Li L. A comprehensive assessment of statin discontinuation among patients who concurrently initiate statins and CYP3A4-inhibitor drugs; a multistate transition model. Br J Clin Pharmacol. 2023 Jul;89(7):2076-2087. doi: 10.1111/bcp.15373. Epub 2022 May 16. PMID: 35502121.
• Chiang CW, Zhang P, Wang X, Wang L, Zhang S, Ning X, Shen L, Quinney SK, Li L. Translational High-Dimensional Drug Interaction Discovery and Validation Using Health Record Databases and Pharmacokinetics Models. Clin Pharmacol Ther. 2018 Feb;103(2):287-295. doi: 10.1002/cpt.914. Epub 2017 Dec 11. PMID: 29052226.
• Miano TA, Wang L, Leonard CE, Brensinger CM, Acton EK, Dawwas GK, Bilker WB, Soprano SE, Nguyen TPP, Woody G, Yu E, Neuman M, Li L, Hennessy S. Identifying Clinically Relevant Drug-Drug Interactions With Methadone and Buprenorphine: A Translational Approach to Signal Detection. Clin Pharmacol Ther. 2022 Nov;112(5):1120-1129. doi: 10.1002/cpt.2717. Epub 2022 Aug 20. PMID: 35881659; PMCID: PMC10015595.
• Wu HY, Shendre A, Zhang S, Zhang P, Wang L, Zeruesenay D, Rocha LM, Shatkay H, Quinney SK, Ning X, Li L. Translational Knowledge Discovery Between Drug Interactions and Pharmacogenetics. Clin Pharmacol Ther. 2020 Apr;107(4):886-902. doi: 10.1002/cpt.1745. Epub 2020 Feb 3. PMID: 31863452; PMCID: PMC7883394.
• Zhang P, Wu HY, Chiang CW, Wang L, Binkheder S, Wang X, Zeng D, Quinney SK, Li L. Translational Biomedical Informatics and Pharmacometrics Approaches in the Drug Interactions Research. CPT Pharmacometrics Syst Pharmacol. 2018 Feb;7(2):90-102. doi: 10.1002/psp4.12267. Epub 2018 Jan 9. PMID: 29193890; PMCID: PMC5824109.
• Yao X, Tsang T, Sun Q, Quinney S, Zhang P, Ning X, Li L, Shen L. Mining and visualizing high-order directional drug interaction effects using the FAERS database. BMC Med Inform Decis Mak. 2020 Mar 18;20(Suppl 2):50. doi: 10.1186/s12911-020-1053-z. PMID: 32183790; PMCID: PMC7079342.
• Zeng X, Zhu S, Hou Y, Zhang P, Li L, Li J, Huang LF, Lewis SJ, Nussinov R, Cheng F. Network-based prediction of drug-target interactions using an arbitrary-order proximity embedded deep forest. Bioinformatics. 2020 May 1;36(9):2805-2812. doi: 10.1093/bioinformatics/btaa010. PMID: 31971579; PMCID: PMC7203727.
• Chasioti D, Yao X, Zhang P, Lerner S, Quinney SK, Ning X, Li L, Shen L. Mining Directional Drug Interaction Effects on Myopathy Using the FAERS Database. IEEE J Biomed Health Inform. 2019 Sep;23(5):2156-2163. doi: 10.1109/JBHI.2018.2874533. Epub 2018 Oct 8. PMID: 30296244; PMCID: PMC6745690.
• Zhu A, Zeng D, Zhang P, Li L. Estimating causal log-odds ratio using the case-control sample and its application in the pharmaco-epidemiology study. Stat Methods Med Res. 2019 Jul;28(7):2165-2178. doi: 10.1177/0962280217750175. Epub 2018 Jan 22. PMID: 29355073; PMCID: PMC6416084.
• Zhang P, Li M, Chiang CW, Wang L, Xiang Y, Cheng L, Feng W, Schleyer TK, Quinney SK, Wu HY, Zeng D, Li L. Three-Component Mixture Model-Based Adverse Drug Event Signal Detection for the Adverse Event Reporting System. CPT Pharmacometrics Syst Pharmacol. 2018 Aug;7(8):499-506. doi: 10.1002/psp4.12294. Epub 2018 Aug 9. PMID: 30091855; PMCID: PMC6118321.
• Wang X, Li L, Wang L, Feng W, Zhang P. Propensity score-adjusted three-component mixture model for drug-drug interaction data mining in FDA Adverse Event Reporting System. Stat Med. 2020 Mar 30;39(7):996-1010. doi: 10.1002/sim.8457. Epub 2019 Dec 27. PMID: 31880829; PMCID: PMC9292662.
• Wang X, Zhang P, Chiang CW, Wu H, Shen L, Ning X, Zeng D, Wang L, Quinney SK, Feng W, Li L. Mixture drug-count response model for the high-dimensional drug combinatory effect on myopathy. Stat Med. 2018 Feb 20;37(4):673-686. doi: 10.1002/sim.7545. Epub 2017 Nov 23. PMID: 29171062; PMCID: PMC5771837.
• Zhu A, Zeng D, Shen L, Ning X, Li L, Zhang P. A super-combo-drug test to detect adverse drug events and drug interactions from electronic health records in the era of polypharmacy. Stat Med. 2020 May 15;39(10):1458-1472. doi: 10.1002/sim.8490. Epub 2020 Feb 26. PMID: 32101641; PMCID: PMC7127937.