Overview

Our research interest lies in the molecular and cellular basis of development and reproduction, two fundamental processes for all multicellular organisms. We are particularly interested in the cell and tissue communications that regulate these processes. In embryonic development, interactions between tissues of different cell lineages drive organ formation by activating genetic and epigenetic programs for tissue patterning and cellular differentiation. Tissue interaction also plays a fundamental role in mammalian reproduction as it mediates the actions of sex steroid hormones in reproductive organs. Deregulation of signaling pathways that control tissue communications could lead to conditions such as cancer. Thus, we also investigate the molecular pathogenesis of disorders in reproductive and hormone-target organs. Since mammalian development and reproductive functions are controlled by complex crosstalks among multiple tissues, organs, and systems, we primarily use in vivo mouse models for the investigation.

Understanding the molecular mechanisms underlying the fundamental process of life is a goal of our research. In addition, our research also aims to improve human health through translational research based on the knowledge obtained through basic research.