The Krishna Lab is investigating cortical regions mediating motor improvements after subthalamic nucleus deep brain stimulation in Parkinson’s disease.
Subthalamic nucleus (STN) deep brain stimulation (DBS) improves all motor symptoms (tremor, rigidity and bradykinesia) of Parkinson’s disease (PD) by modulating the cortical activity in several regions (e.g. premotor, motor cortex etc.). However distinct clinical effects are sometimes observed during STN stimulation e.g. rigidity may improve more than tremor. We are investigating the distinct cortical regions involved in improving different motor domains of PD.