The Kolb Lab is devoted to an understanding of the molecular pathways that, when altered, result in diseases of the motor neuron.

Our overall goal is to understand the molecular consequences of genetic variants associated with motor neuron diseases such as amyotrophic lateral sclerosis, spinal muscular atrophy and hereditary motor neuropathy to develop effective therapies of genetic and non-genetic forms of these diseases.

The Kolb Lab is interested in the molecular determinants of the entire life cycle of the motor neuron, and is integrated within a collaborative and multidisciplinary environment with basic, translational and clinical expertise in neuromuscular disorders.