Research Interests

There is a wide range of projects available at P3 research laboratory both for graduate and undergraduate students. These projects investigate various concepts such as:

  • Antibiotic resistance
  • Combination Therapy
  • Bacteriophage-antibiotic synergy
  • Resistance reversion or re-sensitization
  • Resistance prevention
  • Pharmacokinetic/pharmacodynamic in vitro models
  • Biofilm versus planktonic mode of bacterial growth

 

Publications:

      • Kunz Coyne, A.J., Stamper, K., Bleick C., A., Kebriaei, R., Lehman S., Rybak, M.J., Synergistic bactericidal effects of phage-enhanced antibiotic therapy against MRSA biofilms. Microbiol Spectrum. February 2024, 27:e0321223.doi: 10.1128/spectrum.03212-23.

       

      • Kunz Coyne, A.J., Stamper, K., Bleick C., A., Kebriaei, R., Lehman S., Bayer A.S., Rybak, M.J., Phage-antibiotic synergy against daptomycin-nonsusceptible MRSA in an ex vivo simulated endocardial pharmacokinetic/pharmcodynamic model, American Society of Microbiology. February 2024, 20:e0138823.doi:  10.1128/aac.01388-23.

       

      • El Ghali, A., Stamper, K., Kunz Coyne A.J., Holger, D., Kebriaei, R.,Alexander, J., et al. Ciprofloxacin in combination with bacteriophage cocktails against multi-drug resistant Pseudomonas aeruginosa in ex vivo simulated endocardial vegetation models. Antimicrobial Agents and Chemotherapy. October 2023, 25;0(0):e00728-23, doi: https://doi.org/10.1128/aac.00728-23.

       

      • Holger, D.J., El Ghali, A, Bhutani, N., Lev, K.L., Stamper K., Kebriaei, R., et al. Phage-antibiotic combinations against multidrug-resistant Pseudomonas aeruginosa in in vitro static and dynamic biofilm models. Antimicrobial Agents and Chemotherapy. 2023 October 19;0(0):e00578-23, doi: https://doi.org/10.1128/aac.00578-23 .

       

      • Mc Leod, C., Tan, K., Kebriaei, R., Abdul-Mutakabbir J.C., Clinical Appraisal of Cefiderocol in the Treatment of Non-Fermenting Gram-Negative Bacilli, Current Infectious Disease Reports. March 2023, doi:https://doi.org/10.1007/s11908-023-00800-0

       

      • Kunz Coyne, A.J., Stamper, K., El Ghali, A., Kebriaei, R., Biswas, B., Wilson, M., Deschenes, M.V., Tran, T.T., Arias, C.A., Rybak, M.J., Phage-Antibiotic Cocktail Rescues Daptomycin and Phage Susceptibility against Daptomycin-Non-susceptible Enterococcus faecium in a Simulated Endocardial Vegetation Ex Vivo Model. Microbiology Spectrum. June 2023 20:e0034023. doi:  10.1128/spectrum.00340-23.

       

      • Kunz Coyne, A.J.; Stamper, K.; Kebriaei, R.; Holger, D.J.; El Ghali, A.; Morrisette, T.; Biswas, B.; Wilson, M.; Deschenes, M.V.; Canfield, G.S.; Duerkop, B.A.; Arias, C.A.; Rybak, M.J. Phage Cocktails with Daptomycin and Ampicillin Eradicates Biofilm-Embedded Multidrug-Resistant Enterococcus faecium with Preserved Phage Susceptibility. Antibiotics2022, 11, 1175. doi: https://doi.org/10.1128/spectrum.00340-23

       

      • Kebriaei R, Lehman S. M., Shah R. M., Stamper K. C., Kunz Coyne A.J., Holger D., El Ghali A., Rybak M.J., Optimization of Phage-Antibiotic Combinations against Staphylococcus aureus Biofilms. Microbiology Spectrum, May 2023, doi: https://doi.org/10.1128/spectrum.04918-22.

       

      • Fabijan, A.P., Iredell, J., Danis-Woldarcyk K., Kebriaei R.,Abedon S.T., Tranlating phage therapy into the clinic:Recent accomplishments but continuing challenges. PLoS, May 2023 doi: https://doi.org/10.1371/journal.pbio.3002119

       

      • Morrisette T., Stamper K. C., Lev K. L., Kebriaei R., Holger D. J., Abdul-Mutakabbir J. C., Kunz Coyne A. J., Rybak M. J., Evaluation of omadacycline alone and in combination with rifampin against biofilm-producing Staphylococcus aureus and Staphylococcus epidermidis. Antimicrobial Agents and Chemotherapy, June, 2023, doi: https://doi.org/10.1128/aac.01317-22.

       

      • Tran N.N., Morrisette T, Jorgensen SC.J., Orench-Benvenutti J.M., Kebriaei R. Current therapies and challenges for the treatment of Staphylococcus aureus biofilm-related infections. Pharmacotherapy. August 2023, doi: https://doi.org/10.1002/phar.2806.

       

       

      • Kebriaei, R.,Abdul-Mutakabbir, J.C., Stamper, K.C. et al. Targeting Dalbavancin Inoculum Effect: Adjunctive Single Dose of Daptomycin. Infectious Disease and Therapy, October 2023, 12, 2485–2494 (2023), doi: 10.1007/s40121-023-00875-1

       

      • Kunz Coyne, A.J.; Stamper, K.; Kebriaei, R.; Holger, D.J.; El Ghali, A.; Morrisette, T.; Biswas, B.; Wilson, M.; Deschenes, M.V.; Canfield, G.S.; Duerkop, B.A.; Arias, C.A.; Rybak, M.J. Phage Cocktails with Daptomycin and Ampicillin Eradicates Biofilm-Embedded Multidrug-Resistant Enterococcus faecium with Preserved Phage Susceptibility. Antibiotics2022, 11, 1175. doi: https://doi.org/10.3390/antibiotics11091175

       

      • Kebriaei, R., Bayer, A. S., Lapitan, C. K., Rybak, M. J., Somerville, G. A., & Mishra, N. N. Activity of the Lactate Dehydrogenase Inhibitor Oxamic Acid against the Fermentative Bacterium Streptococcus mitis/oralis: Bactericidal Effects and Prevention of Daptomycin Resistance In Vitro and in an Ex Vivo Model. Antibiotics 2022, 11(10), 1409. doi: https://doi.org/10.3390/antibiotics11101409

       

      • Holger D, Lev KL, Kebriaei R, Morrisette T, Shah R, Alexander J, Lehman SM, Rybak MJ. Bacteriophage-antibiotic Combination Therapy for Multidrug-resistant Pseudomonas aeruginosa: In vitro Synergy Testing. Journal of Applied Microbiology 2022, doi: 1111/jam.15647

       

       

      • Kebriaei R., Lev K., Shah R., Stamper K., Holger D., Morrisette T., Kunz Coyne A., Rybak M.J. Eradication of Biofilm Mediated Methicillin-Resistant Staphylococcus aureus Infections In vitro: Bacteriophage-Antibiotic Microbiology    Spectrum 2022, DOI:10.1128/spectrum.00411-22, doi: https://doi.org/10.1128/spectrum.00411-22.

       

      • Vanamala, K.; Bhise, K.; Sanchez, H.; Kebriaei, R.; Luong, D.; Sau, S.; Abdelhady, H.; Rybak, M.J.; Andes, D.; Iyer, A.K. Folate Functionalized Lipid Nanoparticles for Targeted Therapy of Methicillin-Resistant Staphylococcus aureus. Pharmaceutics 2021, 13, 1791. doi: 10.3390/pharmaceutics13111791

       

      • Morrisette, T., Lev, K.L., Canfield, G.S., Duerkop, B.A., Kebriaei, R., Stamper, K.C., Holger, D., Lehman, S.M., Willcox, S., Arias, C.A. and Rybak, M.J., Evaluation of Bacteriophage Cocktails Alone and in Combination with Daptomycin Against Daptomycin-Nonsusceptible Enterococcus faecium. Antimicrobial agents and chemotherapy, doi: https://doi.org/10.1128/AAC.01623-21

       

      • Kebriaei R., Lev K., Stamper K., Morrisette T., Abdul-Mutakabbir J.C., Schuch R., Lehoux D., Rybak M.J. Exabacase, in Addition to Daptomycin against MRSA. Antimicrobial Agents and Chemotherapy 2021, DOI:10.1128/AAC.00128-21, doi: https://doi.org/10.1128/spectrum.00411-22. .

       

      • Abdul-Mutakabbir, J.C.; Yim, J.; Nguyen, L.; Maassen, P.T.; Stamper, K.; Shiekh, Z.; Kebriaei, R.; Shields, R.K.; Castanheira, M.; Kaye, K.S.; Rybak, M.J. In Vitro Synergy of Colistin in Combination with Meropenem or Tigecycline against Carbapenem-Resistant Acinetobacter baumannii. Antibiotics 2021, doi:10.3390/antibiotics10070880.

       

      • Barber, K.E.; Shammout, Z.; Smith, J.R.; Kebriaei, R.; Morrisette, T.; Rybak, M.J. Biofilm Time- Kill Curves to Assess the Bactericidal Activity of Daptomycin Combinations against Biofilm- Producing Vancomycin-Resistant Enterococcus faecium and faecalis. Antibiotics 2021, doi:10.3390/antibiotics10080897

       

      • Abdul-Mutakabbir J., Nguyen L., Maassen P.T., Stamper K.C., Kebriaei R., Kaye K.S., Castanheira M., Rybak M.J., In vitro Antibacterial Activity of Cefiderocol against Multidrug- Resistant Acinetobacter, Antimicrobial Agents and Chemotherapy 2021, doi:10.1128/AAC.02646-20

       

      • Holger , Kebriaei R., Morrisette T., Lev K., Alexander J., Rybak M.J., Clinical Pharmacology of Bacteriophage Therapy: A Focus on Multidrug-Resistant Pseudomonas aeruginosa Infections, Antibiotics 2021, doi: 10.3390/antibiotics10050556

       

      • Kebriaei , Basu A.S., Microfluidic protein detection and quantification using droplet morphology. Microfluidics and Nanofluidics 2021, doi: 10.1007/s10404-021-02443-w

       

      • Morrisette , Alosaimy S., Abdul-Mutakabbir J., Kebriaei R., Rybak M.J., The Evolving Reduction of Vancomycin and Daptomycin Susceptibility in MRSA Salvaging the Gold Standards with Combination Therapy. Antibiotics 2020, doi: 10.3390/antibiotics9110762

       

      • Kebriaei , Lev K., Stamper K., Lehman M. S., Morales S., Rybak M.J., Bacteriophage AB-SA01 Cocktail in Combination with Antibiotics against MRSA-VISA Strain: In vitro Pharmacokinetic/Pharmacodynamic Model. Antimicrobial Agents and Chemotherapy 2020, doi: https://doi.org/10.1128/aac.00128-21.

       

      • Abdul-Mutakabbir J., Morrisette T., Alosaimy S., Kebriaei R., Rybak M.J., Cefiderocol: A Novel Siderophore Cephalosporin against Multidrug-Resistant Gram-Negative Pathogens. Pharmacotherapy, 2020, DOI: 10.1002/phar.2476.

       

      • Abdul-Mutakabbir J., Kebriaei R., Stamper K.C., Shiekh Z., Maassen P., Lev K.L., Rybak M.J., Dalbavancin, vancomycin, and daptomycin alone and in combination with cefazolin against resistant phenotypes of Staphylococcus aureus in a pharmacokinetic/ pharmacodynamic model. Antibiotics 2020, DOI:10.3390/antibiotics9100696

       

      • Morrisette , Lev K.L., Kebriaei R., Abdul-Mutakabbir J., Stamper K.C, Morales S., Lehman S.M, Canfield G.S., Duerkop B.A., Arias C.A., Rybak M.J., Bacteriophage-antibiotic combinations for Enterococcus faecium with varying bacteriophage and daptomycin susceptibilities. Antimicrobial Agents and Chemotherapy Antimicrobial Agents and Chemotherapy 2020, doi: https://doi.org/10.1128/AAC.01623-21

       

      • Jorgensen S. CJ., Kebriaei R., Dresser L.D., Remdesivir: Review of pharmacology, pre‐clinical data and emerging clinical experience for COVID‐ Pharmacotherapy 2020, doi: 10.1002/phar.2429.

       

      • Kebriaei , Morrisette T., Lev K., Stamper K., Rybak M.J., Bacteriophage-Antibiotic Combination Strategy: An Alternative against Methicillin-resistant Phenotypes of Staphylococcus aureus, Antimicrobial Agents and Chemotherapy Antimicrobial Agents and Chemotherapy 2020, doi:10.1128/AAC.00461-20.

       

      • Kebriaei , Stamper K.C., Singh K.V., Khan A., Rice S.A., Dinh A.Q., Tran T.T., Murray B.E., Arias C.A., Rybak M.J., Mechanistic Insights into the Differential Efficacy of Daptomycin Plus β-Lactam Combinations Against Daptomycin-Resistant Enterococcus faecium. Journal of Infectious Disease 2020, DOI:10.1093/infdis/jiaa319.

       

      • Kebriaei R, Rice, S. A., Singh N.B., Stamper K. C., Nguyen L., Sheikh Z., Rybak M.J., Combinations of (Lipo)Glycopeptides with β-Lactams against Methicillin- Resistant Staphylococcus aureus: Susceptibility Insights (Journal of Antimicrobial Chemotherapy, 2020, doi: 10.1093/infdis/jiaa319

       

      • Jahanbakhsh , Singh N.B., Yim J., Kebriaei R., Smith J.R., Lev K., Tran T.T., Rose W.E., Arias C.A, Rybak M.J., Impact of Daptomycin Dose Exposure Alone or in Combination with β- lactams or Rifampin against Vancomycin-Resistant Enterococci (VRE) in an In vitro Biofilm Model. Antimicrobial Agents and Chemotherapy 2020, doi: https://doi.org/10.1128/aac.02074-19.

       

      • Alosaimy S., Abdul-Mutakabbir J.C., Kebriaei R., Jorgensen S.CJ. Rybak M., Evaluation of Eravacycline: a Novel Flourocycline. Pharmacotherapy 2020, doi:1002/phar.2366.

       

      • Morrisette , Kebriaei R., Lev K., Morales S., Rybak M.J., Bacteriophage Therapeutics: A Primer for Clinicians on Phage‐Antibiotic Combinations. Pharmacotherapy 2019, doi:10.1002/phar.2358.

       

      • Mikhail S., Singh N. B., Kebriaei R, Rice, S. A., Stamper K. C., Castanheira M., Rybak M.J., Evaluation of the Synergy of Ceftazidime-Avibactam in combination with Meropenem, Amikacin, Aztreonam, Colistin and Fosfomycin Against Well Characterized Multi-Drug Resistant pneumoniae and P. aeruginosa. Antimicrobial Agents and Chemotherapy 2019, doi:10.1128/AAC.00779-19.

       

      • Kebriaei R, Rice, A., Stamper K. C., Seepersaud R., Garcia-de-la-Maria C., Mishra N. N., MiroM., Arias C. A., Tran T. T., Sullam P. M., Bayer A. S., Rybak M. J., Daptomycin dose-ranging evaluation with single vs. multi-dose ceftriaxone combinations against Streptococcus mitis oralis in an ex-vivo simulated endocarditis vegetation model, Antimicrobial Agents and Chemotherapy. 2019, doi:10.1128/AAC.00386-19

       

      • Abdul-Mutakabbir C., Kebriaei R., Jorgensen S. CJ. Teaching an old class new tricks: A novel semi-synthetic aminoglycoside, plazomicin, Infectious Diseases and Therapy, 2019, doi: 10.1007/s40121-019-0239-0

       

      • Kebriaei R., Rice, S. A., Stamper K. C., Rybak M.J, Dalbavancin alone and in combination with ceftaroline against four different phenotypes of Staphylococcus aureus in a PK/PD model, Antimicrobial Agents and Chemotherapy, 2019, doi: https://doi.org/10.1128/aac.01743-18

       

      • Kebriaei R, Rice A., Singh K.V., Stamper K.C., Dinh A.Q., Rios R., Dias L., Murray B.E., Munita J.M., Tran T.T., Arias C.A., Rybak M.J., Efficacy of daptomycin monotherapy and in combination with β-lactams for daptomycin-susceptible Enterococcus faecium harboring LiaSR substitutions influence of the inoculum effect, Antimicrobal Agents and Chemotherapy. 2018,
        doi: https://doi.org/10.1128/aac.00386-19.
      • Xhemali X, Smith JR, Kebriaei R, Rice SA, Stamper K, Compton M, Singh NB, Jahanbakhsh S, Rybak MJ. Evaluation of dalbavancin alone and in combination with β-lactam antibiotics against resistant phenotypes of Staphylococcus aureus. Journal of Antimicrobial Chemotherapy. 2018, doi:10.1093/jac/dky376

       

      • Bhise K, Sau S, Kebriaei R, Rice S, Stamper K, Alsaab HO, Rybak MJ, Iyer Combination of vancomycin and cefazolin lipid nanoparticles for overcoming antibiotic resistance of MRSA. Materials. 2018, doi:10.3390/ma11071245.

       

      • Smith JR, Yim J, Rice S, Kebriaei R, Rybak MJ. The combination of tedizolid and daptomycin against methicillin-resistant Staphylococcus aureus in an in-vitro model of simulated endocardial vegetations. Antimicrobial Agents and Chemotherapy. 2018, doi:10.1128/AAC.00101-18.

 

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