Our research team members are engaged in pre-clinical target identification for pharmacologic treatment of neurodegenerative and psychiatric disorders. We use in vivo and in vitro high-resolution fluorescence microscopy and high-content analysis of live neurons to reveal complex interactions between signaling pathways that regulate cell survival/function and circadian clock signaling. This work is designed to identify new avenues of chronotherapeutic target development for CNS disorders
Principal Investigators
Karl Obrietan, Ph.D. Department of Neuroscience
Kari Hoyt, Ph.D. Division of Pharmaceutics and Pharmacology
Project 1: Alzheimer’s Disease and desynchronization of cortico-limbic circadian rhythms
Project 2: MAPK signaling: gates, oscillators and circadian timing