HTS resources

Assay Guidance Manual

The Assay Guidance Manual by Eli Lilly & Company and the National Center for Advancing Translational Sciences (NCATS),  is considered the gold standard for assay development, assay technologies, and HTS for investigators interested in developing assays for discovery and development of chemical probes and drug candiates. Click here to download the 2018 version (50 MB): Assay Guidance Manual-2018


NCATS AGM Preclinical Translational Science; Webinar Series


Automating and Miniaturizing Gene Expression Assays via High-Throughput RT-qPCR

RT-qPCR offers distinct advantages for gene-expression profiling in the context of compound screening, especially for early stage drug discovery.

This article describes comparison of luciferase reporter assays with RT-qPCR in an HTS format: GEN report on Sep 15, 2014