Collaborative Cross mice
(illustrated by Danica Dy)
Collaborative Cross mice is an innovative panel of recombinant inbred mice. They were derived from 8 founder strains (illustrated above) and offer huge genetic and phenotypic diversities. We use Collaborative Cross mice to investigate the genetic basis of epilepsy and its related neurological disorders.
Study of seizure and its related outcomes
Our lab is tackling key challenges in epilepsy using various seizure models and related techniques.
Flurothyl kindling dynamics in Collaborative Cross mice. (MST, myoclonic seizure threshold; GST, generalized seizure threshold, interval = GST-MST)
Detection of spontaneous recurrent seizures
Pathophysiologic basis of SUDEP
Our lab hosts Tucker-Davis in vivo electrophysiology solution for behavior and electrophysiology recording and manipulation.
Simultaneous recording of behavior, brain, heart, and respiratory activities in freely moving mouse to reveal physiologic cascade that leads to SUDEP