- Badr, A.; Daily, K.P; Eltobgy, M.; Estfanous, S.; Tan, M; Kuo, J.C; Whitham, O.; Carafice, C.; Gupta, G.; Amer, H.M.; Shamseldin, M.M.; Yousif, A.; Deems, N.P.; Fitzgerald, J.; Yan, P.; Webb, A.; Zhang, X.; Pietrzak, M.; Ghoneim, H.E.; Dubey, P.; Barrientos, R.M.; Lee, R.J.; Kokiko-Cochra, O.N.; Amer, A.O. (2024) “Microglia-targeted inhibition of miR-17 via mannose-coated lipid nanoparticles improves pathology and behavior in a mouse model of Alzheimer’s disease”. Brain, Behavior, and Immunity, 119, 919-944.
- Daily, K.P; Badr, A.; Eltobgy, M.; Estfanous, S.; Whitham, O.; Tan, M.; Carafice, C.; Krause, K.; McNamara, A.; Hamilton, K.; Gupta, S.; Fitzgerald, J.; Saadey, A.A.; Laster, B.; Yan, P.; Webb, A.; Zhang, X.; Pietrzak, M.; Kokiko-Cochran, O.N.; Ghoneim, H.E.* and Amer, A.O.* (2024) “DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates inflammation and amyloid-β deposition during Alzheimer’s disease” Alzheimer’s Research and Therapy. 16, 29 (2024).
- Read, K.A.; Jones, D.M.; Pokhrel, S.; Hales, E.D.S; Varkey, A.; Tuazon, J.A.; Eisele, C.D.; Abdouni, O.; Saadey, A.; Leonard, M.R.; Warren, R.T.; Powell, M.D.; Boss, J.M.; Hemann, E.A.; Yount, J.S.; Xin, G.; Ghoneim, H.E.; Lio, CW., Freud, A.G.; Collins, P.L.; and Oestreich, K.J. (2023) “Aiolos represses CD4+ T cell cytotoxic programming via reciprocal regulation of TFH transcription factors and IL-2 sensitivity” Nature Communications; 2023 Mar 24;14(1):1652.
- Soerens, A.G.; Künzli, M.; Quarnstrom, C.F.; Scott, M.C.; Swanson, L.; Locquiao, JJ.; Ghoneim, H.E.; Zehn, D.; Youngblood, B.; Vezys, V.; Masopust, D. (2023) “Functional T cells are capable of supernumerary cell division and longevity” Nature; 614, 762–766.
- Saadey, A.A.; Yousif, A.; Osborne, N.; Shahinfar, R.; Chen, YL; Laster, B.; Rajeev, M.; Bauman, P.; Webb, A; Ghoneim, H.E. (2023) “Rebalancing TGFβ1/BMP-Signals in Exhausted T Cells Unlocks Responsiveness to Immune Checkpoint Blockade Therapy” Nature Immunology; 24(2):280–294.
- Chen, H-Y.; Almonte-Loya, A.; Lay, F-Y.; Hsu, M.; Johnson, E.; Gonzalez-Avalos, E.; Yin, J.; Bruno, R.; Ma, Q.; Ghoneim, H.E.; Wozniak, D.J.; Harrison, F.E.; Lio, CW. (2022) “Epigenetic Remodeling by Vitamin C Potentiates Plasma Cell Differentiation” Elife;11:e73754.
- Saini, A.; Ghoneim, H.E.; Lio, C-WJ.; Collins, P.L.; Oltz, E.M (2022) “Gene Regulatory Circuits in Innate and Adaptive Immune Cells” Annual Review of Immunology, vol.40.
- Saadey, A.A.; Yousif, A.; Ghoneim, H.E. (2022) “Epigenetic programming of the immune responses in cancer”
Cancer Immunology and Immunotherapy Book, Ch.7; Elsevier, Academic Press; 197-235 - Yousif, A. and Ghoneim, H.E. (2021) “T Cell Exhaustion—A Memory Locked Behind Scars” Nature Immunology; 22(8):938-940.
- Zebley, C.C; Abdelsamed, H.A; Ghoneim, H.E; Alli, S.; Brown, C.; Haydar, D.; Mi, T.; Harris, T.; McGargill, M.A.; Krenciute, G.; Youngblood, B. (2021) “Proinflammatory cytokines promote TET2-mediated DNA demethylation during CD8 T cell effector differentiation” Cell Reports; 37(2):109796.
- Fonseca, R.; Beura, L.K.; Quarnstrom, C.F.; Ghoneim, H.E.; Fan, Y.; Zebley, C.C.; Scott, M.C.; Fares-Frederickson, N.J.; Wijeyesinghe, S.; Thompson, E.A.; Borges da Silva, H.; Vezys, V.; Youngblood, B.; Masopust, D. (2020) “Developmental plasticity allows outside-in immune responses by resident memory T cells.” Nature Immunology; 21(4):412-421.
- LeMessurier, K.S.; Rooney, R.; Ghoneim, H.E.; Liu, B.; Li, K.; Smallwood, H.S.; Samarasinghe, A.E. (2020) “Influenza A Virus Directly Modulates Mouse Eosinophil Responses.” Journal of Leukocyte Biology; 108(1):151-168.
- Abdelsamed, H. A.; Zebley, C.C.; Nguyen, h.; Rutishauser, R.L.; Fan, Y.; Ghoneim, H. E.; Crawford, J.C.; Alfei, F.; Alli, S.; Ribeiro, S.P.;, Castellaw, A.; McGargill, M.A.; Jin, H.; Boi, S.K.; Speake, C.; Serti, E.; Turka, L.A.; Busch, M.E.; Stone, M.; Deeks, S.G.; Sekaly, R.P.; Zehn, D.; James, E.; Nepom, G.T; Youngblood, B. (2020) “Beta cell-specific CD8 T cells maintain stem-cell memory-associated epigenetic programs during type 1 diabetes.” Nature Immunology; 21(5):578-87.
- Alfei, F.; Kanev, K.; Hofmann, M.; Wu, M.; Ghoneim, H. E.; Roelli, P.; Utzschneider, D.T.; von Hösslin, M.; Cullen, J.; Fan, Y.; Eisenberg, V.; Wohlleber, D.; Steiger, K.; Merkler, D.; Delorenzi, M.; Knolle, P.A.; Cohen, C. J.; Thimme, R.; Youngblood, B.; Zehn, D. (2019) “Tox reinforces the phenotype and longevity of exhausted T-cells in chronic viral infection” Nature; 571(7764): 265-269.
- Ghoneim, H. E.; Fan, Y.; Moustaki, A.; Abdelsamed, H. A.; Dash, P.; Dogra, P.; Carter, R.; Awad, W.; Neale, G.; Thomas, P. G.; Youngblood, B. (2017) “De Novo Epigenetic Programs Inhibit PD-1 Blockade-Mediated T-Cell Rejuvenation” Cell; 170(1): 142-157. (*Featured in Science Magazine and Faculty of 1000 Prime for special significance)
- Youngblood, B.; Hale, J. S.; Kissick, H. T.; Ahn, E.; Xu, X.; Wieland, A.; Araki, K; West, E. E.; Ghoneim, H. E.; Fan, Y.; Dogra, P.; Davis, C. W.; Konieczny, B. T.; Antia, R.; Cheng, X; Ahmed, R. (2017) “Effector CD8 T Cells Dedifferentiate into Long-Lived Memory Cells” Nature; 552(7685): 404-409.
- Abdelsamed, H. A.; Moustaki, A.; Fan, Y.; Dogra. P.; Ghoneim, H. E.; Zebley, C.; Triplett, B.; Sekaly, R. P.; Youngblood, B. (2017) “Human Memory CD8 T-Cell Effector-Potential is Epigenetically Preserved during In Vivo Homeostasis” Journal of Experimental Medicine; 214(6): 1593-1606.
- Ghoneim, H. E.; Zamora, A.; Thomas, P. G.; Youngblood, B. (2016) “Cell-Intrinsic Barriers of T Cell-Based Immunotherapy” Trends in Molecular Medicine; 22(12): 1000-1011. (*Selected among Trends in Molecular Medicine Best of 2016)
- Dogra, P.; Ghoneim, H. E.; Abdelsamed, H.A.; Youngblood, B. (2016) “Generating Long-lived CD8+ T-Cell Memory: Insights from Epigenetic Programs.” European Journal of Immunology; 46(7): 1548-62.
- Ghoneim, H. E.; and McCullers, J. A. (2014) “Adjunctive Corticosteroid Therapy Improves Lung Immunopathology and Survival during Severe Secondary Pneumococcal Pneumonia in Mice.” Journal of Infectious Diseases; 209(9): 1459-68. (*Highlighted in the St. Jude Scientific Report 2014 for special significance)
- Ghoneim, H. E.; Thomas, P. G.; McCullers, J. A. (2013). “Depletion of Alveolar Macrophages during Influenza Infection Facilitates Bacterial Superinfections.” Journal of Immunology; 191(3): 1250-59. (*Highlighted in the St. Jude Scientific Report 2014 for special significance
- Alymova, I. V.; Green, A. M.; Van De Velde, N.; McAuley, J. L.; Boyd, K. L.; Ghoneim, H. E.; McCullers, J. A. (2011). “Immunopathogenic and Antibacterial Effects of H3N2 Influenza A Virus PB1-F2 Map to Amino Acid Residues 62, 75, 79, and 82.” Journal of Virology; 85(23):12324-33.
- Marcelin, G.; Aldridge, J. R.; Duan, S.; Ghoneim, H. E.; Rehg, J.; Marjuki, H.; Boon, A. C.; McCullers, J. A.; and Webby, R. J. (2011). “Fatal Outcome of Pandemic H1N1 2009 Influenza Virus Infection is Associated with Immunopathology and Impaired Lung Repair, Not Enhanced Viral Burden, in Pregnant Mice.” Journal of Virology; 85(21):11208-19.
- Ellebedy, A. H.; Lupfer, C.; Ghoneim, H. E.; DeBeauchamp, J.; Kanneganti, T. D.; Webby, R. J. (2011). “Inflammasome-Independent Role of the Apoptosis-associated Speck-like Protein Containing CARD (ASC) in the Adjuvant Effect of MF59.”, Proc Natl Acad Sci USA; 108(7):2927-32.