Welcome to the Respiratory Mechanobiology Laboratory website!

Our lab is under the direction of Dr. Samir Ghadiali and is jointly affiliated with the Department of Biomedical Engineering in the College of Engineering and the Davis Heart & Lung Research Institute at the Ohio State University Wexner Medical Center. Our laboratory is located on the medical campus at OSU and is directly linked with the Division of Pulmonary, Critical Care, and Sleep Medicine. We are a highly multidisciplinary lab and members routinely interact with engineers, molecular biologists, biophysicists, and clinical physicians.

Our lab uses a combination of engineering, mathematical and molecular biology tools to investigate how mechanical forces in the human body can alter the development of respiratory and critical care disorders. A major emphasis of our lab is the translation of basic scientific knowledge about how mechanical factors influence disease progression into novel therapeutic agents for several disorders including Otitis Media/Upper Respiratory Infections, Acute Lung Injury, Lung and Breast Cancer and Pulmonary Fibrosis.

We hope you enjoy browsing these pages and learning about our exciting research programs!