4. Publication

Selected Publications:

  1. Dandan Yang, Xiaoping Wan, Neil Schwieterman, Omer Cavus, Ege Kacira, Xianyao Xu, Kenneth R. Laurita, Loren E. Wold, Thomas J. Hund, Peter J. Mohler, Isabelle Deschênes, Ji-dong Fu. MicroRNA-1 deficiency is a primary etiological factor and disrupts the homeostatic regulation of heart contractility and electrophysiology. Circulation: Arrhythmia and Electrophysiology. 2023, In Press
  2. Ege Kacira, Mitchell Pittman, Dandan Yang, Sarah L. Sturgill, Mark T. Ziolo, Yuchi Han, Isabelle Deschênes, and Ji-dong Fu. Long-Axis Biplane Echocardiography Sensitively Detects the Progressing Functional Deterioration of Mouse Heart. Circulation: Heart Failure. 2023, In Press.
  3. Sunil K. Vasireddi, Prasongchai Sattayaprasert, Dandan Yang, Adrienne T. Dennis, Emre Bektik, Ji-dong Fu, Judith A. Mackall, Kenneth R. Laurita. Adipogenic signaling promotes arrhythmia substrates before structural abnormalities in EMEM43 ARVC. J Personal Medicine. 2022 Oct. 9; 12(10):1680. Doi: 10.3390/jpm12101680. PMID: 36294819. PMCID: PMC9604824.
  4. Danan Yang, Isabelle Deschênes, Ji-dong Fu. Multilayer control of cardiac electrophysiology by microRNAs. J Mol Cell Cardiol. 2022 Mar 3; 166:107-115. doi: 10.1016/j.yjmcc.2022.02.007. [Epub ahead of print] Review. PubMed PMID: 35247375.
  5. Yuliang Feng, Liuyang Cai, Wanzi Hong, Chunxiang Zhang, Ning Tan, Mingyang Wang, Cheng Wang, Feng Liu, Xiaohong Wang, Jianyong Ma, Chen Gao, Mohit Kumar, Yuanxi Mo, Qingshan Geng, Changjun Luo, Yan Lin, Haiyang Chen, Shuang-Yin Wang, Michael J. Watson, Anil G. Jegga, Roger A. Pedersen, Ji-dong Fu, Zhao V. Wang, Guo-Chang Fan, Sakthivel Sadayappan, Yigang Wang, Siim Pauklin, Feng Huang, Wei Huang, Lei Jiang. Rewiring of 3D Chromatin Topology Orchestrates Transcriptional Reprogramming and the Development of Human Dilated Cardiomyopathy. Circulation. 2022 Apr 11. doi: 10.1161/CIRCULATIONAHA.121.055781. PMID: 35400201. PMCID: PMC9251830.
  6. Mingchong Yang, Ji-dong Fu, Jizhong Zou, Divya Sridharan, Ming-Tao Zhao, Harpreet Singh, Judith Krigman, Mahmood Khan, Gang Xin, Nuo Sun. Assessment of mitophagy in human iPSC-derived cardiomyocytes. Autophagy. 2022 Feb 27; 1-14. doi: 10.1080/15548627.2022.2037920. PMID: 35220905. PMCID: PMC9542630.
  7. Kenneth T. Laurita, Shenaz Khan, Tracy McMahon, Adrienne T. Dennis, Vincent Li, Robert Baivin, Hima Sapa, Ji-dong Fu, Jeffery R. Schelling. Ventricular arrhythmias in mouse models of diabetic kidney disease. Scientific Reports. 2021 Oct 18;11(1):20570. doi: 10.1038/s41598-021-99891-9. PMID: 34663875. PMCID: PMC8523538.
  8. Emre Bektik, Yu Sun, Adrienne T. Dennis, Phraew Sakon, Dandan Yang, Isabelle Deschênes, and Ji-Dong Fu. Inhibition of CREB-CBP Signaling Improves Fibroblast Plasticity for Direct Cardiac Reprogramming. Cells 2021, 10, 1572. Doi: 10.3390/cells10071572. PMID: 34206684. PMCID: PMC8307124.
  9. Dandan Yang, Xiaoping Wan, Adrienne T. Dennis, Emre Bektik, Zhihua Wang, Mauricio G.S. Costa, Charline Fagnen, Catherine Vénien-Bryan, Xianyao Xu, Daniel H. Gratz, Thomas J. Hund, Peter J. Mohler, Kenneth T. Laurita, Isabelle Deschênes, Ji-dong Fu. MicroRNA biophysically modulates cardiac action potential via directly binding to ion channels. Circulation, 2021 Feb 16. doi: 10.1161/CIRCULATIONAHA.120.050098. PMID: 33590773.
  10. Emre Bektik, Ji-dong Fu. Production of cardiomyocyte-like cells by fibroblast reprogramming with defined factors. Methods Molecular Biology, 2021; 2239:33-46. PMID: 33226611.
  11. Prasongchai Sattayaprasert, Sunil K. Vasireddi, Emre Bektik, Oju Joen, Mohammad hajjiri, Judith A. Mackall, Christine S. Moraves, Eben Alsberg, Jidong Fu, Kenneth R. Laurita. Human cardiac mesenchymal stem cells remodel in disease and can regulate arrhythmia substrates. Circulation: Arrhythmia and Electrophysiology, 2020, Oct; 13(10):e008740. PMID: 32755466.
  12. Emre Bektik, Ji-dong Fu. Ameliorating the fibrotic remodeling of the heart by direct cardiac reprogramming. Cells, 2019, July 4; 8(7). Pii:E679. Doi: 10.3390/Cells8070679. PMID:  31277520.
  13. Emre Bektik, Adrienne T. Dennis, Gary Pawlowski, Chen Zhou, Danielle Maleski, Satoru Takahashi, Kenneth R. Laurita, Isabelle Deschenes, Ji-dong Fu. S-phase Synchronization Facilitates the Early Progression of Induced-Cardiomyocyte Reprogramming through Enhanced Cell-Cycle Exit. J. Mol. Sci. 2018, 19(5), pii: E1364. Doi:10.3390/ijms19051364. PMID: 29734659.
  14. Ji-dong Fu, Kenneth R. Laurita. Repolarization Reserve and action potential Dynamics in failing myocytes. Circ Arrhythm Electrophysiol. 2018 Feb; 11(2): e006137. PMID: 29437766.
  15. Yu Sun, Valeriy Timofeyev, Adrienne T. Dennis, Emre Bektik, Xiaoping Wan, Kenneth R. Laurita, Isabelle Deschenes, Ronald A. Li, Ji-dong Fu. A singular role of IK1 promoting the development of cardiac automaticity during cardiomyocyte differentiation by IK1-induced activation of pacemaker current. Stem Cell Reviews and Reports. 2017 Oct;13(5):631-643. PMID: 28623610.
  16. Emre Bektik, Adrienne T. Dennis, Prateek Prasanna, Anant Madabhushi, Ji-Dong Fu. Single cell qPCR reveals that additional HAND2 and microRNA-1 facilitate the early reprogramming progress of seven-factor-induced human myocytes. PLoS One. 2017;12(8): e0183000. PMID: 28796841.
  17. Yen-Sin Ang, Renee N. Rivas, Alexandre K.S. Ribeiro, Rohith Srivas, Janell Rivera, Nicole R. Stone, Karishma Pratt, Tamer M.A. Mohamed, Ji-Dong Fu, C. Ian Spencer, Nathaniel D. Tippens, Molong Li, Anil Narasimha, Ethan Radzinsky, Anita Moon-Grady, Haiyuan Yu, Beth L. Pruitt, Michael P. Snyder, and Deepak Srivastava. Disease model of GATA4 mutation reveals transcription factor cooperativity in human cardiogenesis. Cell. 2016 Dec 15;167(7):1734-1749. PMID: 27984724. PMID: 27984724.
  18. Nan Cao, Yu Huang, Jiashun Zheng, C. Ian Spencer, Yu Zhang, Ji-Dong Fu, Baoming Nie, Min Xie, Mingliang Zhang, Haixia Wang, Tianhua Ma, Tao Xu, Guilai Shi, Deepak Srivastava, Sheng Ding. Conversion of human fibroblasts into functional cardiomyocytes by small molecules. Science. 2016, Apr 28. PMID: 27127239.
  19. Yang Zhou, Li Wang, Haley Ruth Vaseghi, Ziqing Liu, Rui Lu, Sahar Alimohamadi, Chaoying Yin, Ji-Dong Fu, Greg G. Wang, Jiandong Liu and Li Qian. Bmi1 is a key epigenetic barrier to direct cardiac reprogramming. Cell Stem Cell. 2016, 18(3): 382-95. PMID: 26942853.
  20. Yu Zhang, Nan Cao, Yu Huang, C. Ian Spencer, Ji-dong Fu, Chen Yu, Kai Liu, Baoming Nie, Tao Xu, Ke Li, Shaohua Xu, Benoit G. Bruneau, Deepak Srivastava, Sheng Ding. Expandalbe cardiovascular progenitor cells reprogrammed from fibroblasts. Cell Stem Cell. 2016, 18 (3): 368-81. PMID: 26942852.
  21. Alexandre J.S. Ribeiro, Yen-Sin Ang, Ji-Dong Fu, Renee N. Rivas, Tamer M.A. Mohamed, Gadryn C. Higgs, Deepak Srivastava, Beth L. Pruitt. Contractility of single cardiomyocytes differentiated from pluripotent stem cells depends on physiological shape and substrate stiffness. Proc Natl Acad Sci U S A. 2015, 112(41):12705-10. PMID: 26417073.
  22. Ji-Dong Fu and Deepak Srivastava. Direct reprogramming of fibroblasts into cardiomyocyte for cardiac regenerative medicine. Circulation Journal. 2015, 79: 245-254. PMID: 25744738.  (corresponding author)
  23. Ji-Dong Fu, Nicole R. Stone, Lei Liu, C. Ian Spencer, Li Qian, Yohei Hayashi, Paul Delgado-Olguin, Sheng Ding, Benoit G. Bruneau, Deepak Srivastava. Direct reprogramming of human fibroblasts toward a cardiomyocyte-like state. Stem Cell Reports. 2013, 1: 235-247. PMID: 24319660. (Cover page article)
  24. Deborah K. Lieu,* Ji-Dong Fu,* Nipavan Chiamvimonvat, Kelvin Chan Tung, Gregory P. McNerney, Thomas Huser, Gordon Keller, Chi-Wing Kong, Ronald A. Li. Mechanism- based facilitated maturation of human pluripotent stem cell–derived cardiomyocytes. Circ Arrhythm Electrophysiol. 2013, 6: 191-201. PMID: 23392582. (* Equal Contributions).
  25. Li Qian, Yu Huang, Ian Spencer, Amy Foley, Vasanth Vedantham, Lei Liu, Simon J. Conway, Ji-Dong Fu, Deepak Srivastava. In vivo reprogramming of murine cardiac fibroblasts into cardiomyocytes. Nature, 2012, 485: 593-8. PMID: 22522929.
  26. Ji-Dong Fu, Stephanie N. Rushing, Deborah K. Lieu, Camie W. Chan, Chi-Wing Kong, Lin Geng, Kitchener D. Wilson, Nipavan Chiamvimonvat, Kenneth R. Boheler, Joseph C. Wu, Gordon Keller, Roger J. Hajjar, Ronald A. Li. Distinct roles of microRNA-1 and -499 in ventricular specification and functional maturation of human embryonic stem cell-derived cardiomyocytes. PLoS ONE, 2011, 6: e27417. PMID: 22110643.
  27. Masaki Ieda, Ji-Dong Fu, Paul Delgado-Olguin, Vasanth Vedantham, Yohei Hayashi, Benoit G. Bruneau, Deepak Srivastava. Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. 2010, 142: 375-86. PMID: 20691899.
  28. Ji-Dong Fu, Peng Jiang, Stephanie Rushing, Jing Liu, Nipavan Chiamvimonvat, Ronald A. Li. Na+/Ca2+ exchanger in hESC-derived ventricular cardiomyocytes is a functional determinant of excitation-contraction coupling during cardiac development. Stem Cells and Development, 2010, 19: 773-82. PMID: 19719399.
  29. Ji-Dong Fu, Yunjoon Jung, Camie Chan, Ronald A. Li. An inducible transgene expression system for regulated phenotypic modification of human embryonic stem cells. Stem Cells and Development, 2008, 17: 315-324. PMID: 18447646.
  30. Jin Liu, Jidong Fu, Chung-wah Siu, Ronald Li. Functional sarcoplasmic reticulum for calcium-handling of human embryonic stem cell-derived cardiomyocytes: Insights for driven maturation. Stem Cells, 2007, 25: 3038-3044. PMID: 17872499.
  31. Ji-Dong Fu, Jun Li, David Tweedie, Hui-Mei Yu, Le Chen, Rong Wang, Daniel R. Riordon, Sheryl A. Brugh, Shi-Qiang Wang, Kenneth R. Boheler, Huang-Tian Yang. Crucial role of the sarcoplasmic reticulum in the developmental regulation of Ca2+ transients and contraction in cardiomyocytes derived from embryonic stem cells. The FASEB Journal. 2006, 20: 181-183. PMID: 16249315.

Complete List of Published Work:
https://www.ncbi.nlm.nih.gov/sites/myncbi/jidong.fu.1/bibliography/43622853/public/?sort=date&direction=descending