Mutation of TGFβ-RII eliminates NSAID cancer chemoprevention.

Juana Martín-López, Pierluigi Gasparini, Kevin Coombes, Carlo M. Croce, Gregory P. Boivin and Richard Fishel

http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=23792&pubmed-linkout=1

Congratulations to the authors and their work showing that naproxen dramatically reduced tumorigenesis in and HNPCC mouse model, and that the mechanism work through the TGF-beta signaling pathway.

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