Publications

1. Meyer KM, Malhotra N, Kwak JS, El Refaey M. Relevance of KCNJ5 in Pathologies of Heart Disease. Int J Mol Sci. 2023 Jun 29;24(13). doi: 10.3390/ijms241310849. Review. PubMed PMID: 37446026; PubMed Central PMCID: PMC10341679.
2. Wallace MJ, Malhotra N, Mariángelo JIE, Stevens TL, Young LJ, Antwi-Boasiako S, Abdallah D, Takenaka SS, Cavus O, Murphy NP, Han M, Xu X, Mangoni ME, Hund TJ, Roberts JD, Györke S, Mohler PJ, El Refaey M. Impact of stress on cardiac phenotypes in mice harboring an ankyrin-B disease variant. J Biol Chem. 2023 Jun;299(6):104818. doi: 10.1016/j.jbc.2023.104818. Epub 2023 May 12. PubMed PMID: 37182735; PubMed Central PMCID: PMC10318515.
3. Wu Q, Kumar N, Lafuse WP, Ahumada OS, Saljoughian N, Whetstone E, Zani A, Patton AK, El Refaey M, Webb A, Pietrzak M, Yu L, Kc M, Peeples ME, Ganesan LP, Yount JS, Rajaram MVS. Influenza A virus modulates ACE2 expression and SARS-CoV-2 infectivity in human cardiomyocytes. iScience. 2022 Dec 22;25(12):105701. doi: 10.1016/j.isci.2022.105701. Epub 2022 Dec 2. PubMed PMID: 36474635; PubMed Central PMCID: PMC9715453.
4. Stevens TL, Manring HR, Wallace MJ, Argall A, Dew T, Papaioannou P, Antwi-Boasiako S, Xu X, Campbell SG, Akar FG, Borzok MA, Hund TJ, Mohler PJ, Koenig SN, El Refaey M. Humanized Dsp ACM Mouse Model Displays Stress-Induced Cardiac Electrical and Structural Phenotypes. Cells. 2022 Sep 29;11(19). doi: 10.3390/cells11193049. PubMed PMID: 36231013; PubMed Central PMCID: PMC9562631.
5. Young LJ, Antwi-Boasiako S, Ferrall J, Wold LE, Mohler PJ, El Refaey M. Genetic and non-genetic risk factors associated with atrial fibrillation. Life Sci. 2022 Jun 15;299:120529. doi: 10.1016/j.lfs.2022.120529. Epub 2022 Apr 3. Review. PubMed PMID: 35385795; PubMed Central PMCID: PMC9058231.
6. El Refaey M, Coles S, Musa H, Stevens TL, Wallace MJ, Murphy NP, Antwi-Boasiako S, Young LJ, Manring HR, Curran J, Makara MA, Sas K, Han M, Koenig SN, Skaf M, Kline CF, Janssen PML, Accornero F, Borzok MA, Mohler PJ. Altered Expression of Zonula occludens-1 Affects Cardiac Na(+) Channels and Increases Susceptibility to Ventricular Arrhythmias. Cells. 2022 Feb 14;11(4). doi: 10.3390/cells11040665. PubMed PMID: 35203314; PubMed Central PMCID: PMC8870063.
7. Abdallah D, Malhotra N, El Refaey M. Protein Phosphatase Signaling in Cardiac Myocytes. In: Hund T, Parinandi N, editors. Cardiovascular Signaling in Health and Disease [Internet] Switzerland AG: Springer, Cham; 2022. p.175-196. Available from: https://link.springer.com/content/pdf/10.1007/978-3-031-08309-9_5.pdf.
8. Abdallah D, Malhotra N, El Refaey M. Protein Phosphatase Signaling in Cardiac Myocytes. 2022;. doi: 10.1007/978-3-031-08309-9_5. Review. PubMed PMID: 37988498.
9. Koenig SN, Sucharski HC, Jose EM, Dudley EK, Madiai F, Cavus O, Argall AD, Williams JL, Murphy NP, Keith CBR, El Refaey M, Gumina RJ, Boudoulas KD, Milks MW, Sofowora G, Smith SA, Hund TJ, Wright NT, Bradley EA, Zareba KM, Wold LE, Mazzaferri EL Jr, Mohler PJ. Inherited Variants in SCARB1 Cause Severe Early-Onset Coronary Artery Disease. Circ Res. 2021 Jul 9;129(2):296-307. doi: 10.1161/CIRCRESAHA.120.318793. Epub 2021 May 12. PubMed PMID: 33975440; PubMed Central PMCID: PMC8273129.
10. Wallace MJ, El Refaey M, Mesirca P, Hund TJ, Mangoni ME, Mohler PJ. Genetic Complexity of Sinoatrial Node Dysfunction. Front Genet. 2021;12:654925. doi: 10.3389/fgene.2021.654925. eCollection 2021. Review. PubMed PMID: 33868385; PubMed Central PMCID: PMC8047474.
11. Cavus O, Williams J, Musa H, El Refaey M, Gratz D, Shaheen R, Schwieterman NA, Koenig S, Antwi-Boasiako S, Young LJ, Xu X, Han M, Wold LE, Hund TJ, Mohler PJ, Bradley EA. Giant ankyrin-G regulates cardiac function. J Biol Chem. 2021 Jan-Jun;296:100507. doi: 10.1016/j.jbc.2021.100507. Epub 2021 Mar 4. PubMed PMID: 33675749; PubMed Central PMCID: PMC8040283.
12. Stevens TL, Wallace MJ, Refaey ME, Roberts JD, Koenig SN, Mohler PJ. Arrhythmogenic Cardiomyopathy: Molecular Insights for Improved Therapeutic Design. J Cardiovasc Dev Dis. 2020 May 26;7(2). doi: 10.3390/jcdd7020021. Review. PubMed PMID: 32466575; PubMed Central PMCID: PMC7345706.
13. Mazzone A, Strege PR, Gibbons SJ, Alcaino C, Joshi V, Haak AJ, Tschumperlin DJ, Bernard CE, Cima RR, Larson DW, Chua HK, Graham RP, El Refaey M, Mohler PJ, Hayashi Y, Ordog T, Calder S, Du P, Farrugia G, Beyder A. microRNA overexpression in slow transit constipation leads to reduced Na(V)1.5 current and altered smooth muscle contractility. Gut. 2020 May;69(5):868-876. doi: 10.1136/gutjnl-2019-318747. Epub 2019 Nov 22. PubMed PMID: 31757880; PubMed Central PMCID: PMC7147984.
14. Greer-Short A, Musa H, Alsina KM, Ni L, Word TA, Reynolds JO, Gratz D, Lane C, El-Refaey M, Unudurthi S, Skaf M, Li N, Fedorov VV, Wehrens XHT, Mohler PJ, Hund TJ. Calmodulin kinase II regulates atrial myocyte late sodium current, calcium handling, and atrial arrhythmia. Heart Rhythm. 2020 Mar;17(3):503-511. doi: 10.1016/j.hrthm.2019.10.016. Epub 2019 Oct 14. PubMed PMID: 31622781; PubMed Central PMCID: PMC7056561.
15. Sucharski HC, Dudley EK, Keith CBR, El Refaey M, Koenig SN, Mohler PJ. Mechanisms and Alterations of Cardiac Ion Channels Leading to Disease: Role of Ankyrin-B in Cardiac Function. Biomolecules. 2020 Jan 31;10(2). doi: 10.3390/biom10020211. Review. PubMed PMID: 32023981; PubMed Central PMCID: PMC7072516.
16. Lubbers ER, Murphy NP, Musa H, Huang CY, Gupta R, Price MV, Han M, Daoud GE, Gratz D, El Refaey M, Xu X, Hoeflinger NK, Friel EL, Lancione P, Wallace MJ, Cavus O, Simmons SL, Williams JL, Skaf M, Koenig SN, Janssen PML, Rasband MN, Hund TJ, Mohler PJ. Correction: Defining new mechanistic roles for α II spectrin in cardiac function. J Biol Chem. 2019 Oct 18;294(42):15557. doi: 10.1074/jbc.AAC119.011151. PubMed PMID: 31628198; PubMed Central PMCID: PMC6802497.
17. Roberts JD, Murphy NP, Hamilton RM, Lubbers ER, James CA, Kline CF, Gollob MH, Krahn AD, Sturm AC, Musa H, El-Refaey M, Koenig S, Aneq MÅ, Hoorntje ET, Graw SL, Davies RW, Rafiq MA, Koopmann TT, Aafaqi S, Fatah M, Chiasson DA, Taylor MR, Simmons SL, Han M, van Opbergen CJ, Wold LE, Sinagra G, Mittal K, Tichnell C, Murray B, Codima A, Nazer B, Nguyen DT, Marcus FI, Sobriera N, Lodder EM, van den Berg MP, Spears DA, Robinson JF, Ursell PC, Green AK, Skanes AC, Tang AS, Gardner MJ, Hegele RA, van Veen TA, Wilde AA, Healey JS, Janssen PM, Mestroni L, van Tintelen JP, Calkins H, Judge DP, Hund TJ, Scheinman MM, Mohler PJ. Ankyrin-B dysfunction predisposes to arrhythmogenic cardiomyopathy and is amenable to therapy. J Clin Invest. 2019 Jul 2;129(8):3171-3184. doi: 10.1172/JCI125538. eCollection 2019 Jul 2. PubMed PMID: 31264976; PubMed Central PMCID: PMC6668697.
18. Lubbers ER, Murphy NP, Musa H, Huang CY, Gupta R, Price MV, Han M, Daoud E, Gratz D, El Refaey M, Xu X, Hoeflinger NK, Friel EL, Lancione P, Wallace MJ, Cavus O, Simmons SL, Williams JL, Skaf M, Koenig SN, Janssen PML, Rasband MN, Hund TJ, Mohler PJ. Defining new mechanistic roles for αII spectrin in cardiac function. J Biol Chem. 2019 Jun 14;294(24):9576-9591. doi: 10.1074/jbc.RA119.007714. Epub 2019 May 7. PubMed PMID: 31064843; PubMed Central PMCID: PMC6579463.
19. El Refaey M, Musa H, Smith SA, Binkley PF, Bradley E, Hund TJ, Mohler PJ. Response by El Refaey et al to Letter Regarding Article, “Protein Phosphatase 2A Regulates Cardiac Na(+) Channels”. Circ Res. 2019 Apr 12;124(8):e60-e61. doi: 10.1161/CIRCRESAHA.119.314938. PubMed PMID: 30973807; PubMed Central PMCID: PMC6601626.
20. El Refaey M, Musa H, Murphy NP, Lubbers ER, Skaf M, Han M, Cavus O, Koenig SN, Wallace MJ, Gratz D, Bradley E, Alsina KM, Wehrens XHT, Hund TJ, Mohler PJ. Protein Phosphatase 2A Regulates Cardiac Na(+) Channels. Circ Res. 2019 Mar;124(5):737-746. doi: 10.1161/CIRCRESAHA.118.314350. PubMed PMID: 30602331; PubMed Central PMCID: PMC6395500.
21. Refaey ME, McGee-Lawrence ME, Fulzele S, Kennedy EJ, Bollag WB, Elsalanty M, Zhong Q, Ding KH, Bendzunas NG, Shi XM, Xu J, Hill WD, Johnson MH, Hunter M, Pierce JL, Yu K, Hamrick MW, Isales CM. Kynurenine, a Tryptophan Metabolite That Accumulates With Age, Induces Bone Loss. J Bone Miner Res. 2017 Nov;32(11):2182-2193. doi: 10.1002/jbmr.3224. Epub 2017 Aug 14. PubMed PMID: 28727234; PubMed Central PMCID: PMC5685888.
22. El Refaey MM, Mohler PJ. Ankyrins and Spectrins in Cardiovascular Biology and Disease. Front Physiol. 2017;8:852. doi: 10.3389/fphys.2017.00852. eCollection 2017. Review. PubMed PMID: 29163198; PubMed Central PMCID: PMC5664424.
23. El Refaey M, Xu L, Gao Y, Canan BD, Adesanya TMA, Warner SC, Akagi K, Symer DE, Mohler PJ, Ma J, Janssen PML, Han R. In Vivo Genome Editing Restores Dystrophin Expression and Cardiac Function in Dystrophic Mice. Circ Res. 2017 Sep 29;121(8):923-929. doi: 10.1161/CIRCRESAHA.117.310996. Epub 2017 Aug 8. PubMed PMID: 28790199; PubMed Central PMCID: PMC5623072.
24. Xu L, Park KH, Zhao L, Xu J, El Refaey M, Gao Y, Zhu H, Ma J, Han R. CRISPR-mediated Genome Editing Restores Dystrophin Expression and Function in mdx Mice. Mol Ther. 2016 Mar;24(3):564-9. doi: 10.1038/mt.2015.192. Epub 2015 Oct 9. PubMed PMID: 26449883; PubMed Central PMCID: PMC4786912.
25. Xu J, El Refaey M, Xu L, Zhao L, Gao Y, Floyd K, Karaze T, Janssen PM, Han R. Genetic disruption of Ano5 in mice does not recapitulate human ANO5-deficient muscular dystrophy. Skelet Muscle. 2015;5:43. doi: 10.1186/s13395-015-0069-z. eCollection 2015. PubMed PMID: 26693275; PubMed Central PMCID: PMC4685631.
26. Howie RN, Bhattacharyya M, Salama ME, Refaey ME, Isales C, Borke J, Daoudi A, Medani F, Elsalanty ME. Removal of pamidronate from bone in rats using systemic and local chelation. Arch Oral Biol. 2015 Dec;60(12):1699-707. doi: 10.1016/j.archoralbio.2015.09.001. Epub 2015 Sep 7. PubMed PMID: 26431826; PubMed Central PMCID: PMC4636948.
27. El Refaey M, Watkins CP, Kennedy EJ, Chang A, Zhong Q, Ding KH, Shi XM, Xu J, Bollag WB, Hill WD, Johnson M, Hunter M, Hamrick MW, Isales CM. Oxidation of the aromatic amino acids tryptophan and tyrosine disrupts their anabolic effects on bone marrow mesenchymal stem cells. Mol Cell Endocrinol. 2015 Jul 15;410:87-96. doi: 10.1016/j.mce.2015.01.034. Epub 2015 Jan 28. PubMed PMID: 25637715; PubMed Central PMCID: PMC4444384.
28. Dukes A, Davis C, El Refaey M, Upadhyay S, Mork S, Arounleut P, Johnson MH, Hill WD, Isales CM, Hamrick MW. The aromatic amino acid tryptophan stimulates skeletal muscle IGF1/p70s6k/mTor signaling in vivo and the expression of myogenic genes in vitro. Nutrition. 2015 Jul-Aug;31(7-8):1018-24. doi: 10.1016/j.nut.2015.02.011. Epub 2015 Mar 17. PubMed PMID: 26059377; PubMed Central PMCID: PMC4465076.
29. Refaey ME, Zhong Q, Ding KH, Shi XM, Xu J, Bollag WB, Hill WD, Chutkan N, Robbins R, Nadeau H, Johnson M, Hamrick MW, Isales CM. Impact of dietary aromatic amino acids on osteoclastic activity. Calcif Tissue Int. 2014 Aug;95(2):174-82. doi: 10.1007/s00223-014-9878-z. Epub 2014 Jul 8. PubMed PMID: 25000990; PubMed Central PMCID: PMC4104004.
30. El Refaey M, Zhong Q, Hill WD, Shi XM, Hamrick MW, Bailey L, Johnson M, Xu J, Bollag WB, Chutkan N, Isales CM. Aromatic amino acid activation of signaling pathways in bone marrow mesenchymal stem cells depends on oxygen tension. PLoS One. 2014;9(4):e91108. doi: 10.1371/journal.pone.0091108. eCollection 2014. PubMed PMID: 24727733; PubMed Central PMCID: PMC3984069.
31. Akeel S, El-Awady A, Hussein K, El-Refaey M, Elsalanty M, Sharawy M, Al-Shabrawey M. Recombinant bone morphogenetic protein-2 induces up-regulation of vascular endothelial growth factor and interleukin 6 in human pre-osteoblasts: role of reactive oxygen species. Arch Oral Biol. 2012 May;57(5):445-52. doi: 10.1016/j.archoralbio.2011.10.002. Epub 2011 Oct 29. PubMed PMID: 22041018.