From left: Taylor Bahn, Bradley Cotton, Deena Snoke.
TAYLOR BANH
BANH.4@OSU.EDU
HUMAN SCIENCES, HUMAN NUTRITION
MARTHA BELURY, ADVISOR
DOES OVEREXPRESSION OF ADIPONECTIN PREVENT MUSCLE WASTING IN MICE WITH CANCER CACHEXIA?
Cancer-induced cachexia results in uncontrolled weight loss and is responsible for one-third of all cancer-related deaths. Fat secretes a protein, adiponectin, that I hypothesize protects against muscle loss during cancer cachexia. The purpose of my study is to determine if overexpression of adiponectin can prevent muscle wasting in this disease.
BRADLEY COTTEN
COTTEN.6@OSU.EDU
HUMAN SCIENCES, HUMAN NUTRITION
MARTHA BELURY, ADVISOR
THE FLAVONOIDS, NARINGENIN AND 8-PRENYLNARINGENIN, ACCUMULATE IN SKELETAL MUSCLE AND INCREASE EXPRESSION OF MYOGENIC GENES
Cachexia is a systemic energy-wasting syndrome, characterized by muscle atrophy, adipose tissue wasting, and tumor-driven inflammation. As there are currently no effective therapies to reverse cachexia, my research investigates nutritional therapies that prevent muscle atrophy and promote muscle function in a mouse model of cancer cachexia.
DEENA SNOKE
SNOKE.26@OSU.EDU
HUMAN SCIENCES, HUMAN NUTRITION
MARTHA BELURY, ADVISOR
DO CHEMOTHERAPY AGENTS FOR CANCER TREATMENT IMPAIR MITOCHONDRIAL FUNCTION BY ALTERING PHOSPHOLIPID COMPOSITION?
Chemotherapy causes cardiotoxicity, which prevails years after treatment. Cardiolipin (CL), a phospholipid in mitochondrial membranes, is integral for cellular energy balance. My research investigates changes in CL structure in mice treated with chemotherapy, as well as in a cardiac cell model.