Welcome to the Homepage of Isaac Effiong, MD, MPH. I am a graduate student in the Safety Pharmacology Program of Ohio State University.
This home page was set up to investigate and discuss up-to-date information on toxic substances including the source, route of exposure, mechanism of action, toxicokinetic, signs and symptoms of toxicity, carcinogenicity and the management of the effects of toxic substances
Included in this home page are blogs that discuss the toxic effects of fipronil insecticide, manganese, diethylene glycol and toxic effect of the brown recluse spider.
Fipronil insecticide is a broad-spectrum insecticide that is widely used because it can kill insects and worms that are resistant to other insecticides. This blog discusses the toxic effects and management of the effects that occur when fipronil comes in contact with the skin,is inhaled or ingested. It also discusses the carcinogenetic potential of fipronil. Link to fipronil insecticide: https://u.osu.edu/pesticide/2019/05/26/fipronil-a-phenylpyrazole-pesticides/?preview_id =25&preview_nonce=ef51ccce91&_thumbnail_id=-1&preview=true
Manganese cause toxic effects when exposed to a high degree in humans. High Manganese exposure affects the nervous system and cause Parkinson-like syndrome. This blog also discusses carcinogenic potential of inorganic manganese. Link to manganese: https://u.osu.edu/effiong.3/2019/06/09/metal-toxicology-manganese/?preview_id= 8&preview_nonce=20698d7d0d&_thumbnail_id=-1&preview=true
Diethylene glycol is a commonly used solvent in many industries including the pharmaceutical industry. Most toxic exposures occur through adulterated drugs, when diethylene glycol is substituted for propylene glycol or glycerin in the manufacturing of drugs in developing countries. This blog discusses the toxic effect of diethylene glycol and the public health concerns in use of the solvent in producing drugs that are sold cheaply on the internet. Link to diethylene glycol: https://u.osu.edu/pesticide/2019/07/01/solvent-toxicity-diethylene-glycol/? preview_id=45&preview_nonce=307e4ef7eb&_thumbnail_id=-1&preview=true
The venom of the brown recluse spider is a toxic substance with different and complex mechanism of action of its toxic effects. This blog discusses the identification of the spider, the mechanism of action of the venom and the treatment option for children and adults that have been bitten by the spider. Link to brown recluse spider: https://u.osu.edu/effiong.3/2019 /07/21/brown-recluse-spider/?preview_id =19&preview_nonce=901c0de4f0&_thumbnail_id=-1&preview=true
I know you will enjoy reading though the blogs.