Experimental Cancer Pharmacology Lab

Within the Experimental Cancer Pharmacology Laboratory (ECPL), members of the Baker, Hu and Sparreboom lab actively collaborate on two themes within The Ohio State University College of Pharmacy’s Division of Pharmaceutics & Pharmacology: 1) cancer therapeutics, and 2) drug toxicity.

Mechanistic studies and preclinical investigations are undertaken to identify therapeutic strategies to circumvent clinical drug resistance in Acute Myeloid Leukemia and to mitigate chemotherapy-induced toxicity. Elucidation of mechanisms of drug-drug interactions, both intentional and unintentional, are integral to both areas of investigation. Our collaborative research leverages collective expertise in cancer pharmacology, preclinical models, transcriptomic/proteomic approaches, drug transporters, and pharmacokinetics with the goal of clinical translation to improve outcomes for cancer patients.