Eason

Dr. Hildreth obtained his BS degree in Biology from East Carolina University and his DVM from the North Carolina State University College of Veterinary Medicine. He then went on to complete a small animal rotating medicine and surgery internship at the University of Florida College of Veterinary Medicine and then a small animal surgical residency at the Ohio State University College of Veterinary Medicine. During his surgical residency, he received an extensive training in general, orthopedic, and neurologic surgery and completed a concurrent MS degree evaluating the use of parathyroid hormone-related protein (PTHrP) as an in vitro bone-forming agent with Dr. Ramiro E. Toribio.

After his surgical residency at Ohio State, he stayed to complete a PhD under the guidance of Drs. Thomas J. Rosol and Ramiro E. Toribio. His PhD focused on evaluating the roles of PTHrP in musculoskeletal development and stem cell differentiation using multiple transgenic mouse models. He also investigated the use of PTHrP as a bone-forming agent in mice using a novel bone implant system and advanced imaging modalities (radiography, microcomputed tomography (microCT), and bioluminescence and fluorescence imaging) for the potential treatment of both human and veterinary diseases (osteoporosis, fracture healing, spinal fusion, total joint arthroplasty, bone marrow transplantation). During his PhD, he was funded as a post-doctoral fellow of the National Institute of Health Center for Arthritis, Musculoskeletal, and Skin Diseases and the C. Glenn Barber Fund for Protein Research. During his PhD, he developed an intense interest in the advanced imaging of bone using microCT, particularly in response to bone-forming therapies or genetic modification. This resulted in collaborations where he performed microCT analysis for the bone biology and cancer research laboratories of Drs. Keith A. Hruska and Toshifumi Sugatani at Washington University in St. Louis and Dr. Michael C. Ostrowski of the Ohio State University College of Medicine’s Comprehensive Cancer Center.

Upon completion of his PhD in August 2014, he was hired as an associate faculty member within the Ohio State University College of Veterinary Medicine as an Instructor of Small Animal Surgical Practice. In this role, he teaches bone biology and orthopedics within the first year veterinary curriculum and general surgery and orthopedics within the third year veterinary surgery laboratories. He officially joined the Ostrowski laboratory within the Ohio State University College of Medicine’s Comprehensive Cancer Center as a Post-Doctoral Fellow in May 2015 after a long-standing collaboration. In this role, he is funded by a Pelotonia Post-Doctoral Fellowship and continues to teach within the veterinary curriculum. His current research focus is the investigation of 1) the role of osteoclasts in breast cancer bone metastasis and 2) transcription factors regulating both osteoblast and osteoclast formation.

Eason married his wife Emily in June of 2014. They live in Logan, Ohio with their young American Cocker Spaniel named Raleigh. He is an avid fan of NASCAR’s #48 Lowe’s Chevrolet driver Jimmie Johnson, the NFL’s Carolina Panthers, and Liverpool FC of the English Premier League.

CURRENT ACADEMIC APPOINTMENTS:

Post-Doctoral Fellow, The Ohio State University College of Medicine’s Comprehensive Cancer Center
Associate Faculty, Surgical Practice, The Ohio State University College of Veterinary Medicine

FORMAL EDUCATION:

PhD in Experimental Pathobiology, The Ohio State University, Columbus, OH
MS in Veterinary Clinical Sciences, The Ohio State University, Columbus, OH
DVM, North Carolina State University, Raleigh, NC
BS, Biology, East Carolina University, Greenville, NC

CLINICAL TRAINING:

Small Animal Surgical Residency, The Ohio State University, Columbus, OH
Small Animal Medicine and Surgery Internship, University of Florida, Gainesville, FL

PUBLICATIONS:

Hildreth BE III, Birchard SJ, Rosol TJ, Drost WT. What is your diagnosis? Appendicular extraskeletal mesenchymal chondrosarcoma in a dog. Journal of the American Veterinary Medical Association, in press

Supsavhad W, Dirksen WP, Hildreth BE III, Rosol TJ. p16, pRb, and p53 in feline oral squamous cell carcinoma. Veterinary Sciences 2016 3:18

Carey HA, Bronisz A, Cabrera J, Hildreth BE III, Cuitiño M, Fu Q, Ahmad A, Toribio RE, Ostrowski MC, Sharma SM. Failure to target RANKL signaling through p38-MAPK results in defective osteoclastogenesis in the microphthalmia cloudy-eyed mutant. Journal of Cellular Physiology 2016 231:630-640.

Hildreth BE III, Hernon KM, Dirksen WP, Leong J, Supsavhad W, Boyaka P, Rosol TJ, Toribio RE. Deletion of the NLS and C-terminus of PTHrP decreases osteogenesis and chondrogenesis but increases adipogenesis and myogenesis in murine bone marrow stromal cells. Journal of Tissue Engineering 2015 6:2041731415609928.

Hildreth BE III, Williams M, Dembek KA, Hernon KM, Rosol TJ, Toribio RE. Engraftment and bone mass are enhanced by PTHrP 1-34 in ectopically transplanted vertebrae (vossicle model) and can be non-invasively monitored with bioluminescence and fluorescence imaging. Transgenic Research 2015 24:955-969.

Martin CK, Dirksen WP, Carlton MM, Lanigan LG, Pillai SP, Werbeck JL, Simmons JK, Hildreth BE III, London CA, Toribio RE, Rosol TJ. Combined zoledronic acid and meloxicam reduced bone loss and tumor growth in an orthotopic mouse model of bone-invasive oral squamous cell carcinoma. Veterinary and Comparative Oncology 2015 13:203-217.

Simmons JK, Hildreth BE III, Supsavhad W, Elshafae SM, Hassan BB, Dirksen WP, Toribio RE, Rosol TJ. Animal models of bone metastasis. Veterinary Pathology 2015 52:827-841

Min Y, Liu Y, Poojari Y, Wu JC, Hildreth BE III, Rosol TJ, Epstein AJ. Self-doped polyaniline-based interdigitated electrodes for electrical stimulation of osteoblast cell lines. Synthetic Metals 2014 198:308-313

Simmons JK, Dirksen WP, Hildreth BE III, Dorr C, Williams C, Thomas R, Breen M, Toribio RE, Rosol TJ. Canine prostate cancer cell line (Probasco) produces osteoblastic metastases in vivo. Prostate 2014 74:1251-1265

Aarnes TK, Hubbell JA, Hildreth BE III. Use of sedation and ropivacaine-morphine epidural for femoral head and neck ostectomy in a dog, Journal of Small Animal Practice 2014 55:334-336

Sugatani T, Hildreth BE III, Toribio RE, Malluche HH, Hruska KA. Expression of DGCR8-dependent microRNAs is indispensable for osteoclastic development and bone-resorbing activity. Journal of Cellular Biochemistry 2014 115:1043-1047

Shu ST, Dirksen WP, Lanigan LG, Martin CK, Thudi NK, Werbeck JL, Fernandez SA, Hildreth BE III, Rosol TJ. Effects of parathyroid hormone-related protein and macrophage inflammatory protein-1α in Jurkat T-cells on tumor formation in vivo and expression of apoptosis regulatory genes in vitro. Leukemia and Lymphoma 2012 53:688-698

Wolfe TD, Pillai SP, Hildreth BE III, Lanigan LG, Martin CK, Werbeck JL, Rosol TJ. Effect of zoledronic acid and amputation on bone invasion and lung metastasis of canine osteosarcoma in nude mice. Clinical and Experimental Metastasis 2011 28:377-389

Hildreth BE III, Werbeck JL, Thudi NK, Deng X, Rosol TJ, Toribio RE. PTHrP 1-141 and 1-86 increase in vitro bone formation. Journal of Surgical Research 2010 162:e9-e17

Toribio RE, Brown HA, Novince CM, Marlow B, Hernon K, Lanigan LG, Hildreth BE III, Werbeck JL, Shu ST, Lorch G, Carlton M, Foley J, Boyaka P, McCauley LK, Rosol TJ. The mid-region, nuclear localization sequence, and C-terminus of PTHrP regulate skeletal development, hematopoiesis, and survival in mice. FASEB Journal 2010 24:1947-1957

Pozzi A, Hildreth BE III, Rajala-Schultz PJ. Comparison of arthroscopy and arthrotomy for the diagnosis of medial meniscal pathology: An ex vivo study. Veterinary Surgery 2008 37(8):749-755

Hildreth BE III, Johnson KA. Ulnocarpal arthrodesis for the treatment of radial agenesis in a dog. Veterinary Comparative Orthopaedics and Traumatology 2007 20(3):231-235

Hildreth BE III, Marcellin-Little DJ, Roe SC, Harrysson OLA. In vitro evaluation of five canine tibial plateau leveling methods. American Journal of Veterinary Research 2006 67(4):693-700

Hildreth BE III, Ellison GW, Roberts JF, Adin CA, Holloway TJ, Archer LL, Van Gilder JM. Biomechanical and histologic comparison of single-layer continuous Cushing and simple continuous appositional cystotomy closure by use of poliglecaprone 25 in rats with experimentally induced inflammation of the urinary bladder. American Journal of Veterinary Research 2006 67(4):686-692

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