Publications & Patents

  1. Corrigan, T.S.; Lotti Diaz, L.M.; Border, S. E.; Ratigan, S. C.; Kasper, K. Q.; Sojka, D.; Fajtova, P.; Caffrey, C.R.; Salvesen, G. S.; McElroy, C. A.; Hadad, C. M.; Ekici, O. D. Design, Synthesis, and In Vitro Evaluation of Aza-peptide Aldehydes and Ketones as Novel and Selective Protease Inhibitors, J. Enz. Inh. & Med. Chem., 2020, 35 (1), 1387-1402
  2. Zhang, Q.; Franjesevic, A.; Corrigan, T. S.; Coldren, W.H.; Dicken, R.; Sillart, S.; DeYong, A.; Yoshino, N.; Smith, J.; Fabry, S.; Fitzpatrick, K.; Blanton, T.G.; Joseph, J.; Yoder, R.J.; McElroy, C.A.; Ekici, O. D.; Callam, C.S.; Hadad, C.M. Demonstration of In Vitro Resurrection of Aged Acetylcholinesterase after Exposure to Organophosphorous Chemical Nerve Agents. J. Med. Chem., 2018, 61 (16), 7034–7042
  3. Ozlem Dogan Ekici, Christopher Hadad, Thomas Corrigan., Preparation of Azapeptide Aldehydes and Ketones as Protease Inhibitors. From PCT Int. Appl. (2017) WO 2017151587 WO 2017-US19900 EP 2017-760591
  4. Yoder, R.J.; Zhang, Q.; Beck, J.M; Franjesevic, A.; Blanton, T.G.; Sillart, S.; Secor, T.; Guerra, L.; Brown, J.D.; Reid, C.; McElroy, C.A.; Ekici, O. D.; Callam, C.S.; Hadad, C.M. Study of para-Quinone Methide Precursors Towards the Realkylation of Aged Acetylcholinesterase. ACS Med. Chem. Lett., 2017, 8 (6), 622–627
  5. Dalbey, R.E., Pei, D., Ekici, O.D. Signal Peptidase Enzymology and Substrate Specificity Profiling, Methods in Enzymology, 2017, 584, 35-58
  6. Zhuang, Q., Young, A., Callam, C.S., McElroy, C. A., Ekici, O. D., Yoder, R. J., Hadad, C. M., Efforts towards Treatments against Aging of Organophosphorus-inhibited Acetylcholinesterase. Annals of the New York Academy of Sciences 2016, 1374, 94-104
  7. Ekici, O. D., Zhu, J., Chung, I., V, Y, Paetzel, M., Dalbey, R. E., Pei, D., Profiling the Substrate Specificity of Viral Protease VP4 by a FRET-Based Peptide Library Approach. Biochemistry, 2009, 48 (24), 5753-5759
  8. Ekici, O. D., Paetzel, M., Dalbey, R. E., Unconventional Serine Proteases: Variations on the Catalytic Ser/His/Asp Triad Configuration. Protein Science, 2008, 17(12), 2023-2037
  9. Ekici, O. D., Paetzel, M., Lively, M. O., Pei, D., Dalbey, R. E., Karla A., Altered -3 Substrate Specificity of Escherichia Coli Signal Peptidase 1 Mutants as Revealed by Screening a Combinatorial Peptide Library. J. Biol. Chem., 2007, 282, 417-425
  10. Ekici, O. D., Li, Z., Campbell, A. J., James, K. E., Asgian, J. L., Mikolajczyk, J., Salvesen, G. S., Ganesan, R., Jelakovic, S., Grutter, M. G., Powers, J. C., Design, Synthesis, and Evaluation of Aza-peptide Michael Acceptors as Selective and Potent Inhibitors of Caspases -2, -3, -6, -7, -8, -9, -10. J. Med. Chem., 2006, 49(19), 5728-5749
  11. James Powers, Marion Gotz, Ozlem Dogan Ekici, Juliana Asgian, Karen Ellis, Zhao Zhao Li, Brian Rukamp., Preparation of Peptidyl Propenoyl Hydrazides as Protease Inhibitors. From PCT Int. Appl. (2005) WO 2005080353 A1 20050901
  12. Ekici, O. D., Götz, G. M., James, K. E., Li, Z., Rukamp, B. J., Asgian, J. L., Caffrey, C. R., Hansell, E., Dvorak, J., McKerrow, J. H., Potempa, J., Travis, J., Mikolajczyk, J., Salvesen, G. S., Powers, J. C., Aza-peptide Michael Acceptors: A New Class of Inhibitors Specific for Caspases and Other Clan CD Cysteine Proteases. J. Med. Chem., 2004, 47(8), 1889-1892
  13. James, K. E., Asgian, J. L., Li, Z., Ekici, O. D., Mikolajczyk, J., Salvesen, G. S., Powers, J. C., Design, Synthesis, and Evaluation of Aza-peptide Epoxides as Selective and Potent Inhibitors of Caspases -3, -6,and -8. J. Med. Chem., 2004, 47(6), 1553-1574
  14. Powers, J. C., Asgian, J. L., Ekici, O. D., James, K. E., Irreversible Inhibitors of Serine, Cysteine and Threonine Proteases. Chem. Rev., 2002, 102, 4639-4750